Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: On the Cusp of Transformative Treatments
Discussion Leader: Mark Cookson (National Institute on Aging, NIH, USA)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
Todd Sherer (The Michael J. Fox Foundation, USA)
"Define, Measure, Treat: The Parkinson's Roadmap"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Utilizing New Tools to Study Dopamine and Basal Ganglia Function
Discussion Leader: D. James Surmeier (Northwestern University, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Alexandra Nelson (University of California, San Francisco, USA)
"Dysregulated Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Aryn Gittis (Carnegie Mellon University, USA)
"Insights About Parkinson's Pathophysiology Using a Gradual 6-OHDA Depletion Model"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Markita Landry (University of California, Berkeley, USA)
"Imaging the Effects of Dopamine Agonists and Antagonists on Dopamine Neuromodulation with a Near-Infrared Nanosensor"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Michael Tadross (Duke University, USA)
"A New Way to Study Brain Dynamics, Drugs and Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Lin Tian (University of California, Davis, USA)
"High Resolution Imaging of Dopamine Dynamics with Designed Genetically-Encoded Indicators"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Stephanie Boas (University of Alabama at Birmingham, USA)
"Using Mouse Cell-Type-Specific Neuroanatomical Location of GWAS-Implicated Genes to Identify Vulnerable Cell Types and Circuits in Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Teresa Hastings (University of Pittsburgh, USA) and Malu Tansey (University of Florida College of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dopamine Oxidation and Other Oxidative Stressors in Pathogenesis
Discussion Leader: Teresa Hastings (University of Pittsburgh, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Joseph Mazzulli (Northwestern University, USA)
"Dopamine Oxidation, Glucosylceramide and α-Synuclein"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Roberto Di Maio (University of Pittsburgh, USA)
"Oxidative Modulation of LRRK2 Kinase Activity in Parkinson's Disease Pathogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Lena Burbulla (Feinberg School of Medicine, Northwestern University, USA)
"Dopamine Oxidation Mediates Convergence of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Manish Chamoli (Buck Institute for Research on Aging, USA)
"Pharmacological Modulation of FXR-TFEB Signaling Improves Mitochondrial Function and Prevents Age-Related Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Parkinson's Proteins in Immune Cells
Discussion Leader: Sally Cowley (University of Oxford, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Avi Orr-Urtreger (Genetics Institute, Tel Aviv Sourasky Medical Center, Israel)
"GBA-Associated Parkinson Disease in TASMC Cohort: Inflammatory Aspects"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Danielle Sliter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Parkin, PINK1 and Inflammation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Richard Smeyne (Thomas Jefferson University, USA)
"Peripheral Immune Regulation of LRRK2-Mediated Neurodegeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Kirsten Harvey (University College London, United Kingdom)
"LRRK2-Mediated NFAT and Wnt Signaling in Innate Immune Responses"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Matthew Fell (Merck Research Laboratories, USA)
"Leveraging PBMCs to Guide the Clinical Interrogation of LRRK2 Kinase Inhibitors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Adamantios Mamais (National Institute on Aging, NIH, USA)
"Parkinson Disease-Associated Mutations in LRRK2 Induce Mislocalization of Rab8a and Modulate Transferrin Recycling in Primary Microglia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Single-Cell Profiling Technology: Methods and Results
Discussion Leader: Andrew Singleton (National Institutes of Health, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Kendall Van Keuren-Jensen (Translational Genomics Research Institute, USA)
"Emerging Technologies in Extracellular RNA Profiling and Single Extracellular Vesicle Characterization"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Myriam Heiman (Picower Institute for Learning and Memory / Broad Institute, Massachusetts Institute of Technology, USA)
"Cell Type-Specific Translational Profiling in Mouse Models of Huntington's Disease Reveals Molecular Mechanisms Shared with Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Rita Cowell (Southern Research / University of Alabama at Birmingham, USA)
"Using Single-Cell Transcriptomics Data to Investigate Metabolic Characteristics and Selective Vulnerability of Dopaminergic Neurons in Mouse Models of PD"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Karl Heilbron (23andMe, USA)
"Identifying Parkinson's Disease Risk Factors Using Mendelian Randomization"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Uptake, Release and Transmission of α-Synuclein
Discussion Leader: Laura Volpicelli-Daley (University of Alabama at Birmingham, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Leonidas Stefanis (Biomedical Research Foundation, Academy of Athens, Greece)
"Formation and Clearance of α-Synuclein Seeds in Neuronal and Oligodendroglial Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Sang Myun Park (Ajou University School of Medicine, South Korea)
"Role of FcgammaRIIB Signaling in Parkinson's Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Nicolas Dzamko (The University of Sydney, Australia)
"A Role for TLR2 in Mediating α-Synuclein Pathology in Parkinson's Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Mark Cookson (National Institute on Aging, NIH, USA)
"TM9SF2 as a Novel Receptor for α-Synuclein Fibrils"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Chiara Zurzolo (Institut Pasteur, France)
"Role of Tunneling Nanotubes in the Spreading of α-Synuclein"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tracy Cole (Ionis Pharmaceuticals, USA)
"SNCA Targeted Antisense Oligonucleotides Modulate Progression of Pathological Deposition in Alpha Synuclein Rodent Transmission Models of Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Model Systems
Discussion Leader: Alexandra Nelson (University of California, San Francisco, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Sally Cowley (University of Oxford, United Kingdom)
"Investigating the Function of Parkinson's Disease-Associated Genes in iPSC-Derived Macrophages and Microglia"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Hyunsoo Je (Duke-NUS Graduate Medical School, Singapore)
"Generation of Pathophysiological Midbrain Organoid Model of Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
D. James Surmeier (Northwestern University, USA)
"Loss of Functional Mitochondrial Complex I in Dopaminergic Neurons Triggers a Progressive Parkinsonian Phenotype"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Briana De Miranda (University of Pittsburgh, USA)
"The Environmental Toxicant, Trichloroethylene, Activates LRRK2 and Causes Nigrostriatal Degeneration"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Gut-Brain Axis in Pathogenesis
Discussion Leader: Fabio Blandini (National Institute of Neurology, IRCCS Mondino Foundation, Italy)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
R. Alberto Travagli (Penn State College of Medicine, USA)
"PD: It's Not All in Your Head"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Rodger Liddle (Duke University, USA)
"The Enteroendocrine Cell-Neural Circuit: Implications for the Spread of α-Synuclein"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Timothy Sampson (Emory University, USA)
"Functional Roles for the Gut Microbiome in Experimental Models of PD"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Kathleen Shannon (University of Wisconsin School of Medicine and Public Health, USA)
"Searching the Intestinal Environment for Clues to the Etiology of Parkinson's Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Per Borghammer (Aarhus University Hospital, Denmark)
"Gut-First vs. Brain-First Parkinson's Disease: A Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mary Herrick (Emory University, USA)
"LRRK2: Lurking Between the Brain and Gut"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Parkinson's Biomarker Development
Discussion Leader: Lana Chahine (University of Pittsburgh, USA)
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
Alice Chen-Plotkin (University of Pennsylvania, USA)
"Updating Our Definitions of Parkinson's Disease for a Molecular Age"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
Pier Giorgio Mastroberardino (Erasmus Medical Center, The Netherlands)
"Peripheral Mitochondrial Function as a Surrogate Measure of PD Severity and Its Usefulness in Patient Stratification"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Luigi Zecca (National Research Council, Italy)
"Neuromelanin Detection by Magnetic Resonance Imaging, a Potential Biomarker for Parkinson's Disease"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Warren Hirst (Biogen, USA)
"Progressing a LRRK2 ASO Towards Phase 1 Clinical Studies"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure