Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: On the Cusp of Transformative Treatments
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Define, Measure, Treat: The Parkinson's Roadmap"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Utilizing New Tools to Study Dopamine and Basal Ganglia Function
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Dysregulated Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Insights About Parkinson's Pathophysiology Using a Gradual 6-OHDA Depletion Model"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Imaging the Effects of Dopamine Agonists and Antagonists on Dopamine Neuromodulation with a Near-Infrared Nanosensor"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A New Way to Study Brain Dynamics, Drugs and Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"High Resolution Imaging of Dopamine Dynamics with Designed Genetically-Encoded Indicators"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Using Mouse Cell-Type-Specific Neuroanatomical Location of GWAS-Implicated Genes to Identify Vulnerable Cell Types and Circuits in Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dopamine Oxidation and Other Oxidative Stressors in Pathogenesis
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Dopamine Oxidation, Glucosylceramide and α-Synuclein"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Oxidative Modulation of LRRK2 Kinase Activity in Parkinson's Disease Pathogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Dopamine Oxidation Mediates Convergence of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Pharmacological Modulation of FXR-TFEB Signaling Improves Mitochondrial Function and Prevents Age-Related Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Parkinson's Proteins in Immune Cells
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"GBA-Associated Parkinson Disease in TASMC Cohort: Inflammatory Aspects"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Parkin, PINK1 and Inflammation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Peripheral Immune Regulation of LRRK2-Mediated Neurodegeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"LRRK2-Mediated NFAT and Wnt Signaling in Innate Immune Responses"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Leveraging PBMCs to Guide the Clinical Interrogation of LRRK2 Kinase Inhibitors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Parkinson Disease-Associated Mutations in LRRK2 Induce Mislocalization of Rab8a and Modulate Transferrin Recycling in Primary Microglia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Single-Cell Profiling Technology: Methods and Results
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Emerging Technologies in Extracellular RNA Profiling and Single Extracellular Vesicle Characterization"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cell Type-Specific Translational Profiling in Mouse Models of Huntington's Disease Reveals Molecular Mechanisms Shared with Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Using Single-Cell Transcriptomics Data to Investigate Metabolic Characteristics and Selective Vulnerability of Dopaminergic Neurons in Mouse Models of PD"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Identifying Parkinson's Disease Risk Factors Using Mendelian Randomization"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Uptake, Release and Transmission of α-Synuclein
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Formation and Clearance of α-Synuclein Seeds in Neuronal and Oligodendroglial Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Role of FcgammaRIIB Signaling in Parkinson's Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"A Role for TLR2 in Mediating α-Synuclein Pathology in Parkinson's Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"TM9SF2 as a Novel Receptor for α-Synuclein Fibrils"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Role of Tunneling Nanotubes in the Spreading of α-Synuclein"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"SNCA Targeted Antisense Oligonucleotides Modulate Progression of Pathological Deposition in Alpha Synuclein Rodent Transmission Models of Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Investigating the Function of Parkinson's Disease-Associated Genes in iPSC-Derived Macrophages and Microglia"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Generation of Pathophysiological Midbrain Organoid Model of Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Loss of Functional Mitochondrial Complex I in Dopaminergic Neurons Triggers a Progressive Parkinsonian Phenotype"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Environmental Toxicant, Trichloroethylene, Activates LRRK2 and Causes Nigrostriatal Degeneration"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Gut-Brain Axis in Pathogenesis
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"PD: It's Not All in Your Head"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"The Enteroendocrine Cell-Neural Circuit: Implications for the Spread of α-Synuclein"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Functional Roles for the Gut Microbiome in Experimental Models of PD"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Searching the Intestinal Environment for Clues to the Etiology of Parkinson's Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Gut-First vs. Brain-First Parkinson's Disease: A Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"LRRK2: Lurking Between the Brain and Gut"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Parkinson's Biomarker Development
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
"Updating Our Definitions of Parkinson's Disease for a Molecular Age"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
"Peripheral Mitochondrial Function as a Surrogate Measure of PD Severity and Its Usefulness in Patient Stratification"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Neuromelanin Detection by Magnetic Resonance Imaging, a Potential Biomarker for Parkinson's Disease"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Progressing a LRRK2 ASO Towards Phase 1 Clinical Studies"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure