Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Matching Therapies to Disease
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
"What's Special About Parkinson's Disease - Are Common Molecular Mechanisms Important?"
8:50 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Complex Genetics of Parkinsonism and Related Disorders
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genetics Contribution to Lewy Body Dementia"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Genetics of Progressive Supranuclear Palsy and Related Conditions"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"The Composition and Heterogeneity of Alpha-Synuclein Pathologies in the Human Brain"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Genetics of Parkinson’s Disease in Diverse Ancestry Populations"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dissecting Parkinson's Disease with Long-Read RNA-Sequencing"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"How Do We Get from GWAS Locus to Therapeutic Target in Parkinson's Disease?"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Physiology of Non-Motor Systems Relevant To PD
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Sensory Neuron TLR4 Mediates Gut Inflammation and CNS Immune Activation"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Disruption of Circadian Rhythmicity in Neurodegenerative Disorders"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Basal Ganglia Outflow to the Pedunculopontine Nucleus in Healthy and Parkinsonian Mice"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Lrrk2G2019S Alters Development and Stress-Dependent Recruitment of Brain-Wide Networks in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Nigral and Mixed Pathology in PD
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Pathological Substrates of LRRK2-Related Parkinson's Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Autoimmunity in Prodromal Parkinson's Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Cortical Vulnerability to Protein Pathologies"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"The Genetics Influencing the Risk of Parkinson's Disease Onset and How Parkinson's Disease Manifestations are Distinct"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Using Vision to Understand Dementia in Parkinson’s Disease"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Plasma a-Synuclein Strains in Lewy Body Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Retromer Dysfunction in Parkinson's Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Synaptic Vesicle Endocytosis Deficits in Parkinson's Disease"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Contribution of Synuclein Species to Pathology"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Progressive Emergence of Alterations in Striatal Glutamate and Dopamine Neurotransmission in the VPS35 D620N Knock-in Mouse Model of PD"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"A Role for ATP13A2 Deficiency in Lysosomal Dysfunction"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Lysosomal Dysfunction in Neurodegenerative Diseases: From Tool Development to Novel Biology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Effect of LRRK2 on PGRN, CTSD, GPNMB, and Processing of Pathological Alpha-Synuclein in Myeloid Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Impact of GBA1 and LRRK2 Mutations on Lysosome Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Aging, Cathepsins and Targeted Clearance of Alpha-synuclein in the Lysosome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"LRRK2: A Brake for When Lysosomes Break"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neuroinflammation and Glial Cell Interactions
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"The Function of Reactive Astrocyte Sub-states in Neurodegenerative Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Macrophages: At the Crossroads Between Infection and Neurodegeneration"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Synuclein-Mediated Neuroinflammation in PD Models"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Myenteric Macrophages Protect Against the Spread of Gut Synucleinopathy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cellular and Intracellular Parkinson’s Disease Pathways
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"LRRKing on Lysosomes: Understanding LRRK2's Role in Lysosomal Biology"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"LRRK2 as a Regulator of Immune and Inflammatory Responses via the Lysosome: Lessons from Mice and Men"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"New Insights Into the PINK1 Pathway in Parkinson's Disease"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Microglial Mitochondria and Selective Neuron Vulnerability"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Distinct Roles of Rab Proteins in LRRK2 Pathogenesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Therapeutic Targeting of Inflammasome Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) to Slow Disease Progression in Parkinson’s Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Topics in Neurodegeneration
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"The Role of Stress Granules in Neurodegenerative Diseases"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Basal Ganglia Outflow to the Pedunculopontine Nucleus in Healthy and Parkinsonian Mice"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Anionic Nanoplastic Contaminants Promote a-Synuclein Aggregation in Neurons"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Adult-Onset Knockout of ATP13A2 in the Mouse Ventral Midbrain Disrupts Lysosomal Biology and Causes Progressive Degeneration of Substantia Nigra Dopamine Neurons"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"REST as a Neuroprotective Factor for Parkinson's Disease"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Glutamate Dysregulation Promotes Impulsive Behaviors in a Rodent Model of Parkinson’s Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure