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Parkinson's Disease

Gordon Research Conference

Circuit and Cellular Mechanisms

June 8 - 13, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

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Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Application Information

The application deadline for this meeting was May 11, 2025. You may still submit an application, which may be considered by the conference chair if there is still room available.

Conference Description

The Parkinson's Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Parkinson's Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Underlying Causes and Treatments of Parkinson's Disease Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:10 pm	"A General Perspective on Parkinson's Disease"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 9:05 pm	"Alpha-Synuclein and the Multiple Facets of Parkinson’s Disease"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Non-Rodent Models of Parkinson’s Disease Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Targeting the Gut-Brain Axis: Therapeutic Insights from a Glucocerebrosidase-Deficient Fly Model of Parkinson's Disease"
9:30 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Understanding PINK1/Parkin Function and Dysfunction Using Drosophila: Considerations on Mitophagy, Calcium and Gut-Brain-Microbiome"
10:05 am - 10:15 am	Discussion
10:15 am - 10:50 am	Group Photo / Coffee Break
10:50 am - 11:10 am	"Non-Human Primates in Synucleinopathy Research: A De-Risking Must Have"
11:10 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Movement Related Dopamine in Monkeys"
11:40 am - 11:50 am	Discussion
11:50 am - 12:00 pm	Short Talk Selected from Poster Abstracts
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Genetics, Epigenetics and DNA Repair Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Epigenetics: A Mediator of Environmental Risk for Parkinson’s Disease Across the Lifespan"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"DNA Damage and the DNA Damage Response in Parkinson's Disease"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Broadening the Lens: Enhancing Diversity in Genetic Studies to Uncover Parkinson’s Disease Etiology"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	Short Talk Selected from Poster Abstracts
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Synaptic Function and Plasticity Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Cholinergic Circuit Alterations in Parkinsonian Mice"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Neuromodulatory interplay in the Dorsal Raphe Nucleus: mechanisms of circuit homeostasis and dysfunction"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Synaptic Loss and Cognitive Decline in Parkinson's Disease"
10:25 am - 10:35 am	Discussion
10:35 am - 11:10 am	Coffee Break
11:10 am - 11:30 am	"Brainstem Neuroplasticity in Parkinson's Disease"
11:30 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"Synaptic and Cellular Dysfunction in the Motor Cortex of Parkinsonism"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Recently Identified Parkinson's Disease-associated Genes and Their Mechanisms Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"RAB32 and the Evolution of Familial Parkinson's Disease"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"G6PD Deficiency is Associated with Parkinson’s Disease Onset and Triggers Dopamine Loss"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"PSMF1 Variants Cause a Phenotypic Spectrum from Early-Onset Parkinson's Disease to Perinatal Lethality - From Gene Discovery to Preliminary Functional Data"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	Short Talk Selected from Poster Abstracts
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Role of Aging Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Exploring Hallmarks of Aging as a Avenue for Development of Novel Therapeutics for Parkinson’s and Related Disorders"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Novel Murine Models of PD with Accelerated Senescence and Aging"
10:00 am - 10:10 am	Discussion
10:10 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Mitochondrial Dysfunction in Aging and Idiopathic Parkinson's Disease: What Can We Learn from Induced Neurons?"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"The Utility of Semi-Direct Reprogramming to Model Parkinson's Disease Across Genotypes and Phenotypes"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Selective Vulnerability, Bioenergetics, and Neuroprotection Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Energy Homeostasis in Neurodegeneration"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Linking the Molecular Diversity of Dopamine Neurons to Parkinson's Disease Pathophysiology"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"NAD Augmentation: A Multitarget Neuroprotective Strategy for Parkinson's Disease"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	Short Talk Selected from Poster Abstracts
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	The Normal Role of Alpha Synuclein Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"The Contextual Role of Alpha-Synuclein at the Synapse"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Synaptic Vesicle Binding Dictates α-Synuclein Function and Pathology"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"A Role for Alpha-Synuclein in mRNA Metabolism and Gene Regulation"
10:25 am - 10:35 am	Discussion
10:35 am - 11:10 am	Coffee Break
11:10 am - 11:30 am	"Beyond Synucleinopathies - The Normal Life of A-Synuclein"
11:30 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"Unraveling miRNA-Based Regulation of α-Synuclein"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Addressing Gaps In Neuromodulation Discussion Leader:
7:30 pm - 7:50 pm	"Therapies Orchestrated by Patient's Own Rhythms"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Using Neural Oscillations to Guide Novel Deep Brain Stimulation Therapies"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Cellular Targets for Neuromodulation in the Corticostriatal System: Insights from Rodent Models"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Targeting of Serotonin System to Decrease Anxiety and Depression in Parkinson’s Disease"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS143280. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Parkinson's Disease (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Misc Block : Poster Information

Funding Opportunities

Misc Block : Diversity Funding Information

Registration Fees

Conferee Single Room:

$1,680.00

Conferee Shared Room:

$1,490.00

Conferee Off-Site:

$1,065.00

Guest Single Room:

$1,490.00

Guest Shared Room:

$1,300.00

Guest Off-Site:

$875.00

Child 4-12 yrs Shared Room:

$650.00

Child 4-12 yrs Off-Site:

$438.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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