Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Changes in the Basal Ganglia with Parkinson's
Discussion Leader: Laurie Sanders (Duke University, USA)
3:45 pm - 4:20 pm
David Sulzer (Columbia University Medical Center, USA)
"Changes in the Basal Ganglia with Parkinson's"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathogenic Mechanisms of Parkinson's Disease
Discussion Leader: Kyle Farmer (University of Pittsburgh, USA)
7:30 pm - 7:45 pm
Valerie Joers (Emory University, USA)
"The Role of Cannabinoid Receptors in Immune Dysfunction and Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Rosalind Roberts (McGill University, Canada)
"Identification and Characterization of Novel Neuronal Mitochondrial-Derived Vesicle Cargo: Implications for Mitochondrial Quality Control and Parkinson's Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Manish Chamoli (Buck Institute for Research on Aging, USA)
"Pharmacological Modulation of FXR-TFEB Signaling Improves Mitochondrial Function and Prevents Age-Related Neurodegeneration"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Allison Schaser (Oregon Health & Science University, USA)
"Transport of Alpha-Synuclein Fibril Aggregates in an In Vivo Mouse Model of Parkinson's Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Claudia Gonzalez-Hunt (Duke University Medical Center, USA)
"Novel LRRK2 and Activated ATM Interaction: Implications for Mitochondrial Genome Integrity"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Matthew Keeney (University of Pittsburgh, USA)
"Mitochondria-NADPH Oxidase 2 Interplay: Relevance in Parkinson's Disease"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Parkinson's Disease in the Clinic
Discussion Leader: Meghan Bucher (University of Pittsburgh, USA)
9:00 am - 9:15 am
Hugo Fernandes (University of Cambridge, United Kingdom)
"Single Cell Transcriptomic Profiling of Human PD iPSC Derived Dopamine Neurons"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Nora Bengoa-Vergniory (Oxford Parkinson's Disease Center, University of Oxford, United Kingdom)
"CLR01 Protects Dopaminergic Neurons In Vitro and In Vivo in Mouse and Human Models"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Benjamin Hobson (Columbia University Medical Center, USA)
"Molecular Profiling of Dopamine Neuron Gene Expression Programs After Inflammatory Insult"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Phillip Mackie (University of Florida College of Medicine, USA)
"A Disrupted Immune-Dopamine Link on Parkinson's Disease Patient Macrophages"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Mark Moehle (Vanderbilt University, USA)
"Selective M4 Muscarinic Acetylcholine Receptor Antagonists Relieve Specific Symptom Domains of Parkinsonian Motor Disability"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Shijie Wang (Duke University, USA)
"Biomarkers for Parkinson Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Clinical Diagnosis and Presentation of Parkinson's Disease / Mentorship Component: Transitioning to Research Independence
Discussion Leaders: J. Timothy Greenamyre (Pittsburgh Institute for Neurodegenerative Diseases, USA) and Malu Tansey (University of Florida College of Medicine, USA)
1:30 pm - 1:50 pm
Steven DeWitte (Connecticut Advocates for Parkinson's, USA)
"Parkinson's Disease from a Patient's Perspective"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:30 pm
Panel Discussion
Making the Leap from Academia to Independent Research
Laurie Sanders (Duke University, USA)
Kyle Fraser (Biogen, USA)
Joseph Mazzulli (Northwestern University, USA)
Sarah Huntwork-Rodriguez (Denali Therapeutics, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes