Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Keynote Session: Pattern-Based Image Analysis: Insights into PD Mechanisms
3:15 pm - 3:50 pm
"Pattern-Based Image Analysis: Insights into PD Mechanisms"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Parkinson's Pathology: Molecular, Cellular, and Circuit Dysfunction in Parkinson's Disease
5:30 pm - 5:45 pm
"Basal Ganglia Outflow to the Pedunculopontine Nucleus in Healthy and Parkinsonian Mice"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
"Therapeutic Targeting of Synaptic Vesicle Glycoprotein 2C (SV2C) in Parkinson's Disease"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
"Constitutive Nuclear Accumulation of Endogenous Alpha-Synuclein in Mice Causes Motor Dysfunction and Cortical Atrophy, Independent of Protein Aggregation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"The Impact of Lipid Droplets on Alpha-Synuclein Protein Folding and Aggregation Propensities in Parkinson’s Disease."
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Transcriptomic Analysis of Vesicular Glutamate Transporter-Expressing Dopamine Neurons Reveals Differential Expression of Genes Mediating Vulnerability to Neurodegeneration"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Rhythmic Gene Expression in the Substantia Nigra and Ventral Tegmental Area Dopaminergic Neurons and the Impact of PFFs on the Dopaminergic Molecular Clock"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Multidimensional Immune Interactions in Parkinson's Disease
9:00 am - 9:15 am
"Using Microglial and Immune Cell Signatures from Single-Nucleus Profiling to Identify Neuroimmune Interactions and Therapeutic Targets for Parkinson Disease"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Effects of Alpha-Synuclein Fibrils on Human Microglia in Adult Mouse Brain"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Mutant LRRK2 Exacerbates Immune Response and Neurodegeneration in a Chronic Model of Experimental Colitis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Comparison of the Ability of the Pathogen-Associated Molecular Patterns LPS and Poly(I:C) to Trigger Parkinson’s Disease-Like Pathology in Parkin KO Mice"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"The Gut-Brain Axis and Parkinson’s Disease: Are Type-I Interferons the Link?"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Using Non-Invasive Focused Ultrasound to Mitigate Alpha Synuclein Propagation in a Parkinson’s Disease Rat Model"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Parkinson's Up Close: A Patient's Perspective / Mentorship Panel
1:30 pm - 1:50 pm
"Parkinson's Up Close: A Patient's Perspective"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:30 pm
Panel Discussion
Mentorship Panel: “What Comes Next?” Constructing a Path to Independence
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes