Sunday, June 8
- 5:00-6:00 - Reception (Phase 1)
- 6:00-7:00 - Dinner
Sunday evening: Host-Microbe Interactions
Chair: Alan Ezekowitz
- 7:30 - Introduction and announcements - Bob Clark, U TX HSC San Antonio
- 7:45 - Microbial recognition by phagocytes - Alan Ezekowitz, Harvard
- 8:00 Discussion
- 8:10 - The Zanvil Cohn Lecture: Phagocyte antimicrobial proteins - Peter Elsbach, NYU
- 8:40 - Discussion
- 8:55 - Microbial endotoxin and phagocytes - Robert Munford, U.TX Southwestern
- 9:15 - Discussion
- 9:30 - End of session
- 9:30-11:00 - Reception (Phase 2)
Monday, June 9
- 7:30-8:30 - Breakfast
- 8:45 - Group Photograph
Monday morning: Chemokines and Chemokine Receptors
Chair: Phil Murphy
- 9:00 - Structure and evolution of chemokine receptors - Phil Murphy, NIH
- 9:20 - Discussion
- 9:30 - Role of chemokines in tissue injury - Caroline Hébert, Genentech
- 9:55 - Discussion
- 10:15 - Break
- 10:30 - Chemokine receptors and HIV pathogenesis - Phil Murphy, NIH
- 10:55 - Discussion
- 11:15 - Roles of chemokine receptors in asthma and AIDS - Charles MacKay, Leukosite
- 11:40 - Discussion
- 12:00 - Short presentations - Chair: Dick Johnston, Yale
- 12:00 - IL-8 receptor desensitization via phosphorylation - Kim Stanton, Albany
- 12:05 - Discussion
- 12:10 - Differences in signaling via CXCR1 and CXCR2 - Cindy Knall, National Jewish
- 12:15 - Discussion
- 12:20 - Three-D model of the formyl peptide receptor - John Mills, Montana St. U.
- 12:25 - Discussion
12:30 - End of Session
- 12:30-1:30 - Lunch
- 1:30-4:30 - Free Time
- 4:30-5:45 - Posters (Group A)
- 6:00-7:00 - Dinner
Monday evening: Myelopoiesis
Chair: Hal Broxmeyer
- 7:30 - Regulation of hematopoiesis by cytokines - Hal Broxmeyer, Indiana U.
- 7:55 - Discussion
- 8:10 - Transcriptional regulation of myelopoiesis - Daniel Tenen, Beth Israel
- 8:35 - Discussion
- 8:50 - Metabolic signals that regulate myeloipoiesis - Daniel Wright, Boston U.
- 9:15 - Discussion
- 9:30 - End of Session
Tuesday, June 10
Tuesday morning: Signal Transduction
Chair: Karl-Heinz Krause
- 9:00 - Phagocyte calcium signalling in cell activation and host pathogen interaction - Karl-Heinz Krause, U.Geneva
- 9:25 - Discussion
- 9:40 - Spatial and temporal aspects of calcium signals - Patricia Camacho, U.Virginia
- 10:05 - Discussion
- 10:20 - Break
- 10:35 - Tyrosine kinases and phosphatases - Giorgio Berton, U.Verona
- 11:00 - Discussion
- 11:15 - PKC isotypes and lipid cofactors - Helen Korchak, U.Penn.
- 11:40 - Discussion
- 11:55 - Short presentations - Chair: Henry Rosen, U. Washington
- 11:55 - PI 3-kinase-dependent signaling in phagocytes - Marcus Thelen, U. Bern
- 12:00 - Discussion
- 12:05 - HL-60 variant defective in PMA activation - François Boulay, CEA-Grenoble
- 12:10 - Discussion
- 12:15 - Rho family proteins in FcýR-mediated phagocytosis - Emmanuelle Caron, U. College London
- 12:20 - Discussion
12:25 - Business meeting (nominations for next Vice Chair)
12:30 - End of Session
- 12:30-1:30 - Lunch
- 1:30-4:30 - Free Time
- 4:30-5:45 - Posters (Group A)
- 6:00-7:00 - Dinner
Tuesday evening: Protein Biosynthesis, Processing and Targeting
Chair: Bill Nauseef
- 7:30 - Molecular chaperones - Bill Nauseef, U. Iowa
- 7:55 - Discussion
- 8:10 - Proteolytic processing of the cathelicidins - Tomas Ganz, UCLA
- 8:35 - Discussion
- 8:50 - Mechanism of organellar targeting - Niels Borregaard, U. Copenhagen
- 9:15 - Discussion
- 9:30 - End of Session
Wednesday, June 11
Wednesday morning: The Respiratory Burst Oxidase
Chair: Linda McPhail
- 9:00 - Oxidase components, assembly, and activation - Linda McPhail, Bowman-Gray
- 9:15 - Molecular interactions of oxidase proteins - Mark Quinn, Montana St.U.
- 9:40 - Discussion
- 9:55 - Small GTPases and associated proteins - Mark Philips, NYU
- 10:20 - Discussion
- 10:35 - Break
- 10:50 - Activation mechanisms in the cell-free oxidase - Elizabeth Ligeti, Semmelweis U
- 11:15 - Discussion
- 11:30 - Gene therapy of CGD: Patient and animal studies - Harry Malech, NIH
- 11:55 - Discussion
- 12:10 - Short Presentations - Chair: Bernie Babior, Scripps
- 12:10 - An arginine and lysine-rich domain of gp91phox - Karla Biberstine-Kinkade, Indiana U.
- 12:15 - Discussion
- 12:20 - Isolation of soluble assembled NADPH oxidase - Edgar Pick, Tel Aviv U.
- 12:25 - Discussion
- 12:30 - End of Session
- 12:30-1:30 - Lunch
- 1:30-4:30 - Free Time
- 4:30-5:45 - Posters (Group B)
- 6:00-7:00 - Dinner
Wednesday evening: The Neutrophil Cytoskeleton
Chair: Sally Zigmond
- 7:30 - Overview - Actin polymerization in phagocytes - Sally Zigmond, U.Penn.
- 7:45 - Cytoskeletal elements in signalling and motility - Tom Stossel, Harvard
- 8:10 - Discussion
- 8:25 - Membrane receptors and the cytoskeleton - Al Jesaitis, Montana St.U.
- 8:50 - Discussion
- 9:05 - Short presentations - Chair: Tom Leto, NIH
- 9:05 - Actin-binding protein p57 in PMN phagosomes - Lee-Ann Allen, U. Iowa
- 9:10 - Discussion
- 9:15 - PKC isoforms translocate to PMN cytoskeleton - Jennifer Nixon, Bowman-Gray
- 9:20 - Discussion
9:25 - Business meeting (election of next Vice Chair)
9:30 - End of Session
Thursday, June 12
Thursday morning: Phagocytes and Tissue Injury - The Double-Edged Sword
Chair: Seymour Klebanoff
- 9:00 - Overview of phagocyte toxic products - Seymour Klebanoff, U. Washington
- 9:15 - Role of myeloperoxidase-induced oxidants in atherosclerosis - Jay Heinecke, Washington U.
- 9:40 - Discussion
- 9:55 - Peroxynitrite and nitrotyrosine in inflammation - Joe Beckman, UAB
- 10:20 - Discussion
- 10:35 - Break
- 10:50 - Fas ligand in phagocyte-mediated tissue injury - Conrad Liles, U.Washington
- 11:15 - Discussion
- 11:30 - Secretory products of the osteoclast that mediate bone resorption - Dave Roodman, U. TX, HSC, San Antonio
- 11:55 - Discussion
- 12:10 - Short Presentations - Chair: Richard Ye, Scripps
- 12:10 - PU.1 is essential for p47phox promoter activity - Sen-Lin Li, U. TX HSC San Antonio
- 12:15 - Discussion
- 12:20 - Endotoxin tolerance: Role of phosphorylation - Barb Yoza, Bowman-Gray
- 12:25 - Discussion
12:30 - End of Session
- 12:30-1:30 - Lunch
- 1:30-4:30 - Free Time
- 4:30-5:45 - Posters (Group B)
- 6:00-7:00 - Banquet
Thursday evening: Phagocyte Adhesion, Locomotion and Vascular Egress
Chair: Sam Silverstein
- 7:30 - Phagocyte-endothelium-matrix interactions - Sam Silverstein, Columbia
- 7:45 - Selectin-mediated adhesion and signalling - Rodger McEver, U.Oklahoma
- 8:10 - Discussion
- 8:25 - In vivo analysis of phagocyte adhesion - Paul Kubes, U.Calgary
- 8:50 - Discussion
- 9:05 - Short presentations - Chair: Mary Dinauer, Indiana U.
- 9:05 - Down-regulation of NADPH oxidase via PAK2 - Isabelle de Mendez, NIH
- 9:10 - Discussion
- 9:15 - PAKs: Regulation and role in NADPH oxidase - Ulla Knaus, Scripps
- 9:20 - Discussion
- 9:30 - End of Session
Friday, June 13
- 7:30-8:30 - Breakfast
- 9:00 - Bus Departure for Logan Airport
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