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Phagocytes

Gordon Research Conference

June 6 - 11, 1999
Chair Alan B. Ezekowitz
Vice Chair William M. Nauseef

Conference Program

Sunday, June 6

Sunday Afternoon

3:00 - 5:00pm Registration
5:00 - 6:00pm Reception
6:00 - 7:00pm Dinner

Sunday Evening:

7:30 - 7:45pm Alan Ezekowitz
Chairman's Introduction
7:45 - 9:30 Hematopoiesis and Lineage Determination
7:45 - 7:50pm Chair: William Nauseef, University of Iowa
Introduction
7:50 - 8:20pm Stuart Orkin, Harvard Medical School
"Transcription Factor Function in Hematopoiesis."
8:20 - 8:35pm Discussion
8:35 - 9:00pm Daniel Tenen, Harvard Medical School
"Determination of Phagocyte Lineage Development by Transcription Factors PU.1 and C/EBPα"
9:00 - 9:20pm Nancy Berliner, Yale University School of Medicine
"Translational Regulation of Late Neutrophil-specific Gene Expression."
9:20 - 9:30pm Discussion
Monday, June 7

Monday Morning:

7:30 - 8:30am Breakfast
8:45 Group Photograph
9:00 - 12:30pm Phagocytosis and Host Defense
9:00 - 9:10am Chair: Thomas Stossel, Harvard Medical School
Introduction
9:10 - 9:40am Alan Aderem, University of Washington School of Medicine
"Molecular Mechanisms of Phagocytosis"
9:40 - 9:55am Discussion
9:55 - 10:25am Eric Brown, University of California, San Francisco
"Regulation of Leukocyte Integrin Adhesion"
10:25 - 10:40am Discussion
10:40 - 10:50am Break
10:50 - 11:10am Joel Swanson, University of Michigan Medical School
"Phagocytosis and Membrane Trafficking in Activated Macrophages."
11:10 - 11:25am Discussion
11:25 - 11:45am Steven Greenberg, College of Physicians & Surgeons, Columbia University
"Modular Components of Phagocytosis."
11:45 - 12:00 Discussion
12:00 - 12:20pm Emmanuelle Caron, University College London
"Small GTP-binding Proteins and the Control of Phagocytosis."
12:20 - 12:30pm Discussion
12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
4:30 - 5:45pm Poster Session Viewing
6:00 - 7:00pm Dinner

Monday Evening:

7:30 - 9:30pm Macrophages and Development
7:30 - 7:35pm Chair: Richard Johnston, National Jewish Medical & Research Center
Introduction
7:35 - 8:00pm Nathalie Franc, Harvard Medical School
"Croquemort is Essential for Efficient Phagocytosis of Apoptotic Cells by Macrophages."
8:00 - 8:05pm Discussion
8:05 - 8:30pm Michael Hengartner, Cold Spring Harbor Laboratory
"Phagocytosis of Dying Cells in C. elegans."
8:30 - 8:35pm Discussion
8:35 - 9:00pm Gary Bokoch, Scripps Research Institute
"Mechanisms of Cytoskeletal Regulation by p21-activated Kinases."
9:00 - 9:05pm Discussion
9:05 - 9:30pm Richard Lang, New York University School of Medicine
"Macrophage Induced Programmed Cell Death."
Discussion
Tuesday, June 8

Tuesday Morning:

7:30 - 8:30am Breakfast
9:00 - 11:30am Innate Immunity
9:00 - 9:10am Chair: Peter Elsbach, New York University School of Medicine
Introduction
9:10 - 9:30am Marie Lagueux, Institute of Molecular & Cell Biology, CNRS, Strasbourg
"Innate Immunity in Insects: The Defense System of Drosophila"
9:30 - 9:45am Discussion
9:45 - 10:10am Carl Nathan, Weill Medical College of Cornell University
"NO and NO resistance genes in the host-parasite relationship"
10:10 - 10:25am Discussion
10:25 - 10:35am Break
10:35 - 11:00am Ruslan Medzhitov, Yale University School of Medicine
"Toll Receptor Family and Innate Immune Recognition."
11:00 - 11:15am Discussion
11:15 - 12:30pm Short Talks
Chairs: William Nauseef, University of Iowa
Virginia Shepherd, Vanderbilt University/VA Medical Center

Brian Egan, Vanderbilt University
Albion Wright, Kansas State University
Iain Fraser, Harvard Medical School
Zulfiqar Malik, University of Iowa
Jurgen Roes, University College, London

12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
4:30 - 5:45pm Poster Session Viewing
6:00 - 7:00pm Dinner

Tuesday Evening:

7:30 - 8:15pm Talks from the Poster Session
Chairs: William Nauseef, University of Iowa
Virginia Shepherd, Vanderbilt University/VA Medical Center

Adam Rupper, Louisiana State University
Serhan Sakarya, University of Maryland
Trista Schagat, Duke University

8:15 - 9:30pm Regulation of Inflammation I
8:15 - 8:25pm Chair: Robert Clark, University of Texas Health Science Center
Introduction
8:25 - 8:50pm Jeffrey Ravetch, Rockefeller University
"Fc Receptors: Activators and Inhibitors of Inflammation"
8:50 - 9:00pm Discussion
9:00 - 9:25pm Michael Carroll, Harvard Medical School
"The Complement System: A Major Regulator of Inflammation"
9:25 - 9:30pm Discussion
Wednesday, June 9

Wednesday Morning:

9:00 - 10:30am NADPH Oxidase Updates
9:00 - 9:15am Chairs; Bernard Babior, Scripps Research Institute & Edgar Pick, Sackler School of Medicine
Introduction: Edgar Pick "Quo Vadis Oxidase?"
Short Talks to be selected from the Poster Session
9:15 - 9:20am Mary Dinauer, Indiana University
"Rac2 Activation of the NADPH Oxidase."
9:20 - 9:25am Discussion
9:25 - 9:35am Lydia M. Henderson, University of Bristol
"Functional Role for Histidine 115 gp91phox in Oxidase-associated H+ Channel."
9:35 - 9:40am Discussion
9:40 - 9:50am Daniel R. Ambruso, Bonfils Blood Center, Denver
"A Novel Neutrophil (PMN) Dysfunction Syndrome: Infections and Poor Wound Healing Associated with Defective Motility, Normal Expression and Function of CD11b and Diminished Contact of Rac-2."
9:50 - 9:55am Discussion
9:55 - 10:05am Françoise Morel, Laboratoire D'Enzymologie, CHU, Grenoble
"NADPH Oxidase Assembling through Cytochrome b558."
10:05 - 10:10am Discussion
10:10 - 10:20am Frank R. DeLeo, University of Iowa
"NADPH Oxidase Activation and Assembly during Phagocytosis."
10:20 - 10:25am Discussion
10:30 - 10:45am Break
10:45 - 12:30pm Regulation of Inflammation II
10:45 - 11:00am Chair: Craig Gerard, Harvard Medical School
Introduction
11:00 - 11:25am Andrew Luster, Harvard Medical School
"Chemokines: Linking Innate and Acquired Immunity."
11:25 - 11:40am Discussion
11:40 - 12:05 pm Steven Shapiro, Washington University School of Medicine
"Role of Elastases in Inflammation and Host Defense."
12:05 - 12:20pm Discussion
12:20 - 12:30pm Business Meeting
(Nominations for next Chair)
12:30 - 1:30pm Lunch
1:30 - 4:30pm Free Time
6:00 - 7:00pm Dinner

Wednesday Evening:

7:30 - 8:30pm Phagocyte Endothelial Cell Interaction
7:30 - 7:40pm Chair: Samuel Silverstein, College of Physicians & Surgeons, Columbia University
Introduction
7:40 - 8:00pm Claire Doerschuk, Harvard Medical School
"Adhesive and Biomechanical Properties of Neutrophils and Endothelial Cells"
8:00 - 8:10pm Discussion
8:10 - 8:30pm William Muller, Weill Medical College of Cornell University
"Transendothelial Migration of Leukocytes: Molecules and Mechanisms."
Discussion
8:30 - 9:30pm Bacterial Host Interactions
8:30 - 8:40pm Chair: Seymour Klebanoff, University of Washington School of Medicine
Introduction
8:40 - 9:00pm Robert Munford, University of Texas SW Medical School
"CD14-dependent utilization of extracellular phosphatidylinositol by monocytes"
9:00 - 9:10pm Discussion
9:10 - 9:30pm Samuel Wright, Merck Research Laboratories
"Recognition and transport of lipopoysaccharide"
Discussion
Thursday, June 10

Thursday Morning:

7:30 - 8:30am Breakfast
9:00 - 12:00 Phagocyte Signal Cell Transduction
9:00 - 9:15am Chair: Linda McPhail, Bowman Gray School of Medicine
Introduction
9:15 - 9:40am Giorgio Berton, Institute of General Pathology, Verona
"Signal Transduction in Phagocytic Cells: Role of Tyrosine Kinases"
9:40 - 9:55am Discussion
9:55 - 10:10am Break
10:10 - 10:35am Philip Stahl, Washington University School of Medicine
"Signal transduction, early endosomes and phagosome maturation"
10:35 - 10:55am Discussion
10:55 - 11:20am Sergio Grinstein, Hospital for Sick Children, Toronto
"Membrane Traffic during Phagosome Formation and Maturation."
11:20 - 11:35am Discussion
11:35 - 12:30pm Short Talks

Cindy Knall, National Jewish Center for Immunol & Respiratory Medicine
Kersi Pestonjamasp, University of Massachusetts School of Medicine
Patrizia Scapini, University of Verona
Jayasree Nath, Walter Reed Army Institute of Research

12:30 - 1:30pm Lunch
1:30 - 4:30pm Free time
6:00 - 7:00pm Banquet

Thursday Evening:

7:30 - 8:30pm The Zanvil Cohn Lecture
7:30 - 7:35pm Alan Ezekowitz
Introduction
7:40 - 8:10pm Siamon Gordon, William Dunn School of Pathology, Oxford
"The Macrophage and Tissue Homeostasis."
8:10 - 8:30pm Discussion
8:30 - 9:30pm Short Talks
Chair: William Nauseef, University of Iowa

Marie-Josephe Rabiet, INSERM, Grenoble
Hattie Gresham, University of New Mexico School of Medicine
Elaine Larsen, Albany Medical College
Krishnakumar Balasubramanian, M.D. Anderson Cancer Center
Friday, June 11

Friday Morning:

7:30 - 8:30am Breakfast
9:00am Bus Departure for Logan Airport

Contributors

The following organizations have generously provided financial support for the meeting:

National Institute of Allergy and Infectious Diseases
Society for Leukocyte Biology
March of Dimes Birth Defects Foundation
Merck Research Laboratories
Genentech, Inc.

Conference Links

Conference History
Additional Fee Info

Phagocytes (GRS)
May 31 - June 1, 2025


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