| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 8:25 pm | The Zanvil Cohn Lecture |
| 7:30 pm - 7:40 pm | Chair's Introduction |
| 7:40 pm - 8:25 pm | Sam Silverstein (College of Physicians and Surgeons, Columbia University)
"Integrative studies of leukocyte effector functions" |
| 8:25 pm - 9:30 pm | Regulation of Myelopoiesis I |
| 8:25 pm - 9:00 pm | Stu Orkin (Harvard Medical School, Children's Hospital, Dana Farber Cancer Institute)
"Transcription control of myeloid gene expression" |
| 9:00 pm - 9:30 pm | Dan Tenen (Beth Israel-Deaconess Hospital, Harvard Medical School)
"Transcription factor levels and myelopoiesis: amount, not size, does matter" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Actin and Membrane Dynamics |
| 9:00 am - 9:10 am | Discussion Leader: Tom Stossel (Brigham and Women's Hospital, Harvard Medical School)
"Overview of phagocyte motility" |
| 9:10 am - 9:45 am | Fred Maxfield (Weill Medical College of Cornell University)
"Effects of cholesterol and membrane organization on macrophage migration and phagocytosis" |
| 9:45 am - 10:20 am | Fred Southwick (University of Florida College of Medicine)
"The role of phosphoinositides in Listeria actin-based motility" |
| 10:20 am | Coffee Break |
| 10:40 am - 11:15 am | Becky Worthylake (Louisiana State University)
"How RhoA directs monocyte migration" |
| 11:15 am - 11:50 am | Tom Stossel (Brigham and Women's Hospital, Harvard Medical School)
"Role of filamin on polarity of migrating cells" |
| 11:50 am - 12:10 pm | Isabelle Maridonneau-Parini (CNRS, France) - Short Talk |
| 12:15 pm | Group Photo |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Inflammation and Disease |
| 7:30 pm - 7:40 pm | Discussion Leader: Dirk Roos (Sanquin Research at CLB, Amsterdam)
"Overview of role in phagocytes in inflammatory disorders" |
| 7:40 pm - 8:15 pm | Dan Kastner (National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health)
"Fever, genes, and history: misadventures in the genomics of inflammation" |
| 8:15 pm - 8:50 pm | Lisa Coussens (University of California, San Francisco)
"Adaptive and innate immune cells regulate premalignant progression" |
| 8:50 pm - 9:30 pm | John Harlan (University of Washington School of Medicine)
"Regulation of inflammation by anti-apoptotic agents" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:40 am | Regulation of Myelopoiesis II |
| 9:00 am - 9:10 am | Discussion Leader: Bob Clark (University of Texas Health Science Center)
"Overview of myelopoiesis" |
| 9:10 am - 9:45 am | Dan Link (Washington University School of Medicine)
"Mechanisms of disordered granulopoiesis in congenital neutropenia" |
| 9:45 am - 10:20 am | Klaus Ley (University of Virginia Health System)
"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17" |
| 10:20 am | Coffee Break |
| 10:40 am - 12:30 pm | Leukocyte/Endothelial Cell Interactions |
| 10:40 am - 10:50 am | Discussion Leader: Gary Bokoch (The Scripps Research Institute)
"Overview of leukocyte responses to adhesion" |
| 10:50 am - 11:25 am | Claire Doerschuk (Case Western Reserve University School of Medicine)
"Neutrophil adhesion-initiated endothelial cell signaling and Rac2" |
| 11:25 am - 12:00 pm | Olga Barreiro (Hospital de La Princesa, Madrid, Spain)
"Endothelial docking structure for adherent leukocytes: molecular components and regulation by tetraspanin microdomains" |
| 12:00 pm - 12:15 pm | Jessica Moreland (Roy J. & Lucille H. Carver College of Medicine, University of Iowa) - Short Talk |
| 12:15 pm - 12:30 pm | Anat Herskovits (University of California, Berkeley) - Short Talk |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Innate Immunity and Toll Receptors |
| 7:30 pm - 7:40 pm | Discussion Leader: Alan Ezekowitz (Massachusetts General Hospital, Harvard Medical School)
"Overview of cellular integration of innate immune responses" |
| 7:40 pm - 8:15 pm | Bruce Beutler (The Scripps Research Institute)
"Analysis of innate immunity by random germline mutagenesis in mice" |
| 8:15 pm - 8:50 pm | Jin Mo Park (Massachusetts General Hospital, Harvard Medical School)
"Modulation of macrophage immune responses by pathogenic bacterial toxins" |
| 8:50 pm - 9:30 pm | Roland Strong (Fred Hutchinson Cancer Research Center)
"Siderocalin, siderophores & iron: innate anti-bacterial responses based on nutrient depletion" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Phagocytosis and Host Pathogen Interactions |
| 9:00 am - 9:10 am | Discussion Leader: Siamon Gordon (Sir William Dunn School of Pathology, University of Oxford)
"Overview of phagocytosis" |
| 9:10 am - 9:45 am | Sergio Grinstein (University of Toronto, The Hospital for Sick Children)
"Mechanisms and functional consequences of phagosomal remodeling" |
| 9:45 am - 10:20 am | Steve Greenberg (Columbia University Medical School)
"Adaptor proteins in macrophage immune functions" |
| 10:20 am | Coffee Break |
| 10:40 am - 11:15 am | Lee-Ann Allen (Roy J. & Lucille H. Carver College of Medicine, University of Iowa)
"Effects of Helicobacter pylori on phagocyte membrane trafficking" |
| 11:15 am - 11:50 am | Rick Brown (University of California, San Francisco School of Medicine)
"GPI-anchored proteins in dendritic cell function" |
| 11:50 am - 12:30 pm | Alan Aderem (Institute for Systems Biology)
"A systems approach to dissecting macrophage function" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Microbial Killing |
| 7:30 pm - 7:45 pm | Discussion Leader: Bill Nauseef (Roy J. & Lucille H. Carver College of Medicine, University of Iowa)
"Overview of antimicrobial effectors in the phagosome" |
| 7:45 pm - 8:20 pm | Anthony Segal (Royal Free and University College Medical School, University College London)
"Killing of microbes by NADPH oxidase - radicals out, ion fluxes in (and out)!" |
| 8:20 pm - 8:55 pm | Elizabeth Ligeti (Semmelweis University, Budapest)
"Bacterial killing by neutrophils: are superoxide and K+ ions alternatives or partners" |
| 8:55 pm - 9:30 pm | Tom DeCoursey (Rush University Medical Center)
"Electron transport though the phagocyte NADPH oxidase requires proton efflux" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signal Transduction |
| 9:00 am - 9:10 am | Discussion Leader: Linda McPhail (Wake Forest University School of Medicine)
"Overview of signal transduction in neutrophils" |
| 9:10 am - 9:45 am | Edgar Pick (Sackler School of Medicine, Tel Aviv University)
"E pluribus unum: activation of the phagocyte NADPH oxidase by phoxracomes, [(p47phox) - (p67phox) - (Rac1)] chimeras" |
| 9:45 am - 10:20 am | Michael Yaffe (Center for Cancer Research, Massachusetts Institute of Technology)
"Priming, NADPH oxidase activation, and sepsis" |
| 10:20 am | Coffee Break |
| 10:40 am - 11:15 am | Phill Hawkins (The Inositide Laboratory, Babraham Institute, Cambridge)
"PI3K regulation of the NADPH oxidase" |
| 11:15 am - 12:00 pm | Carl Nathan (Weill Medical College of Cornell University)
"Separate control over the respiratory burst and degranulation in neutrophils: role of soluble adenylyl cyclase in TNF signaling" |
| 12:00 pm - 12:15 pm | Wenyu Ming (Indiana University School of Medicine) - Short Talk |
| 12:15 pm - 12:30 pm | Darren Ritsick (Emory University School of Medicine) - Short Talk |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:05 pm | Emerging Concepts |
| 7:30 pm - 7:40 pm | Discussion Leader: Joel Swanson (University of Michigan Medical School)
"Overview of session" |
| 7:40 pm - 8:15 pm | Late breaking presentation: Charles Serhan (Brigham and Women's Hospital, Harvard Medical School)
"Biosynthesis and actions of resolvins" |
| 8:15 pm - 8:50 pm | Adrian Ozinsky (Institute for Systems Biology)
"Measuring macrophage heterogeneity: Assessing coordinated responses from single cells" |
| 8:50 pm - 9:05 pm | Lynda Stuart (Massachusetts General Hospital, Harvard Medical School)
"Using systems biology to examine the Drosophila phagosome and define the basic template of phagocytosis" |
| 9:05 pm - 9:30 pm | Membrane Trafficking During Phagocytosis |
| Michel Desjardins (University of Montreal) |
| Sergio Grinstein (University of Toronto, The Hospital for Sick Children) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
