SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:40 pm | Dynamics of NADPH oxidase assembly (Lecture in memory of Bernie Babior) |
7:40 pm - 7:50 pm | John Curnutte (Schering-Plough Biopharma) Introduction |
7:50 pm - 8:30 pm | Mary Dinauer (Indiana University School of Medicine)
"Dynamics of NADPH oxidase assembly" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | In vivo dynamics of phagocytes |
8:40 pm - 9:05 pm | Jonathan Mathias (University of Wisconsin) "Using zebrafish to study leukocyte motility" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Chemotaxis |
9:00 am - 9:15 am | Discussion Leader: Phil Murphy (NIAID, NIH) |
9:15 am - 9:45 am | Peter Devreotes (Johns Hopkins University School of Medicine) "Lipid signaling in chemotaxis, phagocytosis and cytokinesis" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Andrew Luster (Massachusetts General Hospital) "Chemoattractant control of phagocyte trafficking in disease" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:15 am | Dianne Cox (Albert Einstein College of Medicine) "The role of WASP/WAVE proteins in macrophage chemotaxis" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Alberto Mantovani (Inst. Clinico Humanitas, Milan)
"The chemokine system in monocyte differentiation and polarization" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Suhasini Kulkarni (Babraham Institute, Cambridge)
"Genetic deficiency in p110beta reveals a critical role for this PI3-kinase isoform in neutrophil inflammatory signalling pathways" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Yitang Li (Harvard Medical School)
"The regulation of neutrophil function by PTEN in a mouse bacterial pneumonia model" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Differentiation |
7:30 pm - 7:45 pm | Discussion Leader: T. Kuijpers (EMMA Children's Hospital, Amsterdam) |
7:45 pm - 8:15 pm | Richard Lang (Childrens Hospital, Cincinnati) "Wnts, macrophages and programmed vascular regression" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Gregory Taylor (Duke University)
"Regulation of macrophage host defense by p47 GTPases" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Denise Monack (Stanford University) "The role of Type I interferon and inflammasome activation in response to cytosolic Francisella" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Phagocytosis |
9:00 am - 9:15 am | Discussion Leader: Eric Brown (Genentech) |
9:15 am - 9:45 am | Clifford Lowell (UCSF) "Convergence of integrin and immunoreceptor signaling pathways in phagocytes" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Emmanuelle Caron (Imperial College, London) "Phagocytosis signalling: a paradigm for adhesion and motility" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:50 am - 11:20 am | Lynda Stuart (Massachusetts General Hospital) "A systems biology approach to phagocytosis" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:55 am | Sergio Grinstein (Hospital for Sick Children) "Phagocyte receptors and membrane remodeling" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Axel Nohturfft (Harvard University)
"Regulation of lysosome/phagosome targeting by IQGAP and IgG" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Florence Niedergang (CNRS, INSERM, Paris)
"Microtubule binding protein CLIP-170 coordinates microtubule and actin reorganisation during phagocytosis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Organelle Trafficking and Secretion |
7:30 pm - 7:45 pm | Discussion Leader: David Russell (Cornell University) |
7:45 pm - 8:15 pm | Mark Marsh (University College, London) "A novel intracellular multivesicular compartment involved in HIV assembly and release" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Gisou van der Goot (University Geneva) "Anthrax toxin receptor: from biosynthesis to lysosomal degradation" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Norma Andrews (Yale University School of Medicine) "Synaptotagmin VII and Ca2+-dependent phagocytosis" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Microbicidal chemistries |
9:00 am - 9:15 am | Discussion Leader: Bill Nauseef (University of Iowa) |
9:15 am - 9:45 am | Gary Bokoch (Scripps Research Institute) "Regulation of NADPH oxidases by Rac GTPases" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Tony Kettle (Christchurch School of Medicine) "Myeloperoxidase: The Cornerstone of microbicidal oxidant production in neutrophils" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:15 am | Deborah Nelson (University Chicago) "CFTR regulation of bactericidal activity in the macrophage" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Frank DeLeo (NIAID, NIH)
"Evasion of innate host defense by bacterial pathogens" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Timo van den Berg (Sanquin, Amsterdam)
"SIRP-alpha functions as a sensor for 'self' controlling the phagocyte NADPH oxidase" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Xing Jun Li (Indiana University School of Medicine)
"A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Innate to Specific Immunity |
7:30 pm - 7:45 pm | Discussion Leader: Alan Ezekowitz (Merck Research) |
7:45 pm - 8:15 pm | Ira Mellman (Genentech) "Cell biology of dendritic cell function" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Dan Portnoy (UC Berkeley) "Induction of type 1 interferon by intracellular pathogens" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Mark Miller (Washington Univ. School of Medicine)
"Imaging phagocyte responses to bacterial infection in situ" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation |
9:00 am - 9:15 am | Discussion Leader: Linda McPhail (Wake Forest University School of Medicine) |
9:15 am - 9:45 am | Ulla Knaus (Scripps Research Institute)
"Role of Rho GTPases in innate immune cell signaling" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Jay Kolls (Childrens Hospital, Pittsburgh)
"The role of phagocyte-derived IL-23 in regulating IL-1 and IL-17 responses to pathogens" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:15 am | Wolfgang Junger (UC San Diego)
"ATP and adenosine guide neutrophil chemotaxis" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Attila Mocsai (Semmelweis University)
"The role of PLCγ2 in neutrophil activation and neutrophil-mediated inflammation in vivo" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:25 pm | Masanori Aikawa (Harvard Medical School)
"Macrophages in atherosclerosis: biology and molecular imaging" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Atherosclerosis |
7:30 pm - 7:45 pm | Discussion Leader: Samuel Silverstein (Columbia University) |
7:45 pm - 8:15 pm | Samuel Wright (Merck Research Laboratories) "Characterization of macrophages in atherosclerotic lesions" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Tracie Seimon (Columbia University) "From host immunity to atherosclerosis: understanding a conserved mechanism of macrophage death" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Stan Hazen (Cleveland Clinic Foundation) "Myeloperoxidase and the development of atherosclerosis" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |