SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | NOVEL TECHNOLOGIES |
7:40 pm - 7:55 pm | Discussion Leader: Sam Silverstein (Columbia University) "Introduction" |
7:55 pm - 8:45 pm | Lecture in memory of Zanvil Cohn: Joel Swanson (University of Michigan)
"Conditional Signaling for Phagocytosis and Pinocytosis" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Jackson Egen (NIAID/NIH)
"In vivo visualization of phagocyte function during the host response to infection" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CELL MIGRATION |
9:00 am - 9:15 am | Discussion Leader: Klaus Ley (La Jolla Institute for Allergy and Immunology) "Introduction" |
9:15 am - 9:40 am | Klaus Ley (La Jolla Institute for Allergy and Immunology)
"PSGL-1-dependent activation of neutrophils and monocytes" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Short Talk: Christoph Riethmüller (University of Münster)
"Transcellular diapedesis of neutrophils is possible close to intact endothelial junctions as shown by force microscopy" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break / Group Photo |
10:25 am - 10:50 am | Tobias Meyer (Stanford University)
"Modular control of endothelial cell migration" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Chuck Parkos (Emory University)
"Molecular basis of JAM-A function" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Martha Cathcart (Cleveland Clinic)
"Signal activated phospholipases control monocyte chemotaxis" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Paige Volk (University of Iowa)
"Role of NADPH oxidase-derived reactive oxygen species in neutrophil chemotaxis signaling" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PATTERN RECOGNITION RECEPTORS |
7:30 pm - 7:45 pm | Discussion Leader: David Underhill (Cedars-Sinai Medical Center) "Introduction" |
7:45 pm - 8:10 pm | Kate Fitzgerald (University of Massachusetts Medical School)
"DNA sensing in the innate immune response" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Paul Heyworth (Schering-Plough)
"Role of the C-type Lectin MDL-1 in Infectious and Inflammatory Disease" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Nick Gay (University of Cambridge)
"Structure and mechanism of signal transduction by the TLRs" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PHAGOCYTOSIS/EXOCYTOSIS |
9:00 am - 9:15 am | Discussion Leader: Joel Swanson (University of Michigan) "Introduction" |
9:15 am - 9:40 am | Julie Magarian Blander (Mount Sinai School of Medicine)
"Innate controls of Treg and TH17 cell differentiation" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Short Talk: Margolein van Egmond (VU University Medical Center)
“Immunoglobulin A - FcγRI interactions induce neutrophil migration through release of leukotriene B4” |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:50 am | Helen Yin (University of Texas Southwestern Medical Center)
"Essential and Unique Roles of Phosphatidylinositol-4-Phosphate-5-Kinases in Phagocytosis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Nathalie Franc (The Scripps Research Institute)
"Genetic dissection of the molecular mechanisms of phagocytosis in Drosophila" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Sergio Catz (The Scripps Research Institute)
"Molecular Mechanisms of Neutrophil Granule Dynamics and Secretion" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Barbara Kazmierczak (Yale University)
"Specific recognition of translocation-competent Type 3 secretion system during Pseudomonas aeruginosa pulmonary infection" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INNATE AND ADAPTIVE IMMUNITY |
7:30 pm - 7:45 pm | Discussion Leader: Hidde Ploegh (Whitehead Institute for Biomedical Research) "Introduction" |
7:45 pm - 8:10 pm | Hidde Ploegh (Whitehead Institute for Biomedical Research)
"New chemical tools to study movement and function of phagocytic receptors and TLRs" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Steffen Jung (The Weizmann Institute of Science)
"Differential Origins and Functions of Intestinal Mononuclear Phagocytes" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Sankar Ghosh (Columbia University)
"New insights into innate immune responses to Salmonella" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | REDOX REGULATION |
9:00 am - 9:15 am | Discussion Leader: Mary Dinauer (Indiana University School of Medicine) "Introduction" |
9:15 am - 9:40 am | Ariel Savina (Institut Curie)
"Role of NADPH oxidase NOX2 in antigen cross presentation in Dendritic Cells" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Short Talk: Jessica Moreland (University of Iowa)
"Neutrophil NADPH oxidase is functional in unstimulated cells" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:50 am | Erzsebet Ligeti (Semmelweis University, Budapest)
"Antibacterial effect of PMN-derived microvesicles" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Rachel Levy (Ben-Gurion University of the Negev)
"The diverse role of cytosolic phospholipase A2alfa in phagocytic cells" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Bob Clark (University of Texas Health Sciences Center - San Antonio)
"Feed-Forward Redox Regulation of NOX2 Activation by Hydrogen Peroxide" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Franck Fieschi (Joseph Fourier University)
"Conformational changes in p47phox upon activation followed by mass spectrometry derived approaches: toward a revised version of the molecular activation of the neutrophilic NADPH oxidase" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | PATHOGEN EFFECTS ON INNATE IMMUNE CELLS |
7:30 pm - 7:45 pm | Discussion Leader: Lee-Ann Allen (University of Iowa) "Introduction" |
7:45 pm - 8:10 pm | David Mosser (University of Maryland)
"Monocyte and macrophage heterogeneity during infectious diseases" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Lynda Stuart (Massachusetts General Hospital)
"Sensing from within - Phagosome dependent microbial recognition" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Lalita Ramakrishnan (University of Washington)
"Monitoring and modulating phagocyte-mycobacterium interactions in the zebrafish" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | INNATE IMMUNE CELLS IN INFLAMMATION |
9:00 am - 9:15 am | Discussion Leader: Bill Nauseef (University of Iowa) "Introduction" |
9:15 am - 9:40 am | Donna Bratton (National Jewish Medical and Research Center)
"NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Macrophage Clearance of Activated and Dying Neutrophils" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Short Talk: Emily Elliott (University of California San Francisco)
"Syk-dependent Neutrophil Effector Functions are Essential for the Development of Antibody Mediated Arthritis" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Coffee Break |
10:25 am - 10:50 am | Charles Serhan (Brigham and Women's Hospital / Harvard Medical School)
"Maresins: A Novel Family of Potent Anti-Inflammatory and Pro-Resolving Mediators From Macrophages" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Moira Whyte (University of Sheffield)
"Regulation of neutrophil function and apoptosis by hypoxia" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Luigina Romani (University of Perugia)
"Balancing inflammation and tolerance to opportunistic fungi" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Madhavi Rane (University of Louisville)
"Akt-mediated NF-E2 phosphorylation induces NFκB activation and neutrophil-mediated acute lung injury in rats" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INNATE IMMUNE CELLS AND DISEASE |
7:30 pm - 7:45 pm | Discussion Leader: Peter Ward (University of Michigan) "Introduction" |
7:45 pm - 8:10 pm | Joseph El-Khoury (Harvard Medical School)
"Scavenger and Toll-like receptors in fungal infections: Brothers in Arms" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Gwen Randolph (Mount Sinai School of Medicine)
"Fate of monocyte-derived cells in atherosclerosis" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Guillermina Girardi (Weill Medical College)
"Activation of Neutrophils by the Tissue factor - Factor VIIa-PAR-2 Axis Mediates Fetal Death in Antiphospholipid Syndrome" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |