SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:55 pm | Chair's Welcome and Introductory Remarks by Lee-Ann Allen (University of Iowa) |
7:55 pm - 9:30 pm | Keynote Lecture: Macrophage Functional Genomics |
7:55 pm - 8:15 pm | Discussion Leader: David Mosser (University of Maryland) |
8:15 pm - 9:05 pm | David Hume (University of Edinburgh)
"Macrophage Functional Genomics"
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9:05 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Bacterial Pathogens and the Host Response |
| Discussion Leader: Frank DeLeo (NIH/NIAID) |
9:05 am - 9:30 am | Frank DeLeo (NIH/NIAID)
"Manipulation of neutrophil function by Staphylococcus aureus"
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9:30 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short talk: Alison Criss (UVA)
"Survival of Neisseria gonorrhoeae after primary human neutrophil challenge"
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9:55 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:55 am | Jason Carlyon (Virginia Commonwealth University)
"Interior decorating: Anaplasma phagocytophilum remodeling of its host-derived vacuole"
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10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Alexander Hoffmann (UCSD)
"Dynamics and Combinatorics in the cellular response to pathogens"
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11:35 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Jeff Schorey (University of Notre Dame)
"Modulation of leukoycte migration and activation by exosomes released from mycobacteria-infected macrophages"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Phagocytes in the Tumor Microenvironment |
| Discussion Leader: Dianne Cox (Albert Einstein/Yeshiva U.) |
7:35 pm - 8:00 pm | Mikael Pittet (Harvard)
"Origins of tumor-associated macrophages and neutrophils"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Lisa Coussens (Oregon Health and Science U.)
"Reprogramming immune responses in solid tumors as a therapeutic strategy"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Short talk: Julian Gomez-Cambronero (Wright State U.)
"PLD small molecule inhibitors at the crossroads of inflammation and cancer"
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9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Short talk: Ya-Ping Ko (Tamu Health Science Center)
"Phagocytosis escape by a bacterial protein that connects Complement and Coagulation proteins at the bacterial surface"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Altered States of Phagocytes in Health and Disease |
| Discussion Leader: Joel Swanson (University of Michigan) |
9:05 am - 9:30 am | V. Hugh Perry (Southampton General Hospital)
"The impact of systemic inflammation on the innate immune cells of the brain in health and disease"
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9:30 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short talk: Douglas Kuhns (Saic-Frederick, Inc.)
"Cytoskeletal abnormalities and neutrophil dysfunction"
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9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:15 am - 10:40 am | Andrea Tenner (U. of California, Irvine)
"Complement mediated inflammation in the brain: new targets for preventing Alzheimer's Disease?"
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10:40 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Akira Takashima (University of Toledo)
"Neutrophil-dendritic cell hybrid - a unique leukocyte population with dual properties of professional phagocytes and antigen-presenting cells"
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11:20 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Mary Dinauer (Washington U.)
"Turning off inflammation: NADPH oxidase and crosstalk with innate lymphocytes"
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12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short talk: Mawadda Alnaeeli (Ohio U., Zanesville campus)
"Erythropoetin: a novel regulator of macrophage recruitment and polarization during obesity-induced white adipose tissue inflammation"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Expanding Role of Neutrophils in Immunity and Inflammation |
| Discussion Leader: Mary Dinauer (Washington U.) |
7:35 pm - 8:00 pm | Jessica Moreland (U. of Iowa)
"Neutrophil priming in inflammatory bowel disease: a benefit or detriment to the host?"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Leo Koenderman (U. of Utrecht)
"Functional compartmentalization of neutrophils: identification of separate subsets of cytotoxic and immune suppressive cells"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Marco Cassatella (U. of Verona)
"Advances in neutrophil biology and immunity"
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9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Migration and Polarization |
| Discussion Leader: Paul Kubes (U. of Calgary) |
9:05 am - 9:30 am | Sussan Nourshargh (Queen Mary University)
"Neutrophil transmigration dynamics in vivo: characterization and implications to tissue damage"
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9:30 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short talk: Mallary Greenlee (U. of Iowa)
"Staphylococcus aureus evades neutrophil and macrophage-mediated immune responses"
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9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:15 am - 10:40 am | Lani Wu (U. Texas Southwestern, Dallas)
"Reverse engineering of information flow in neutrophil polarity networks"
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10:40 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Minsoo Kim (U. of Rochester)
"Local inflammatory cues generated by neutrophil migration"
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11:20 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Anna Huttenlocker (U. of Wisconsin-Madison)
"Imaging leukoycte migration and inflammation in vivo using zebrafish"
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12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short talk: Payal Mehta (Medimmune LLC/AstraZeneca)
"LC3-associated phagocytosis mediates IFN-alpha secretion in response to DNA-immune complexes"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | New Mechanisms of Regulation |
| Discussion Leader: Michelle Lennartz (Albany Medical College) |
7:35 pm - 8:00 pm | Robert Munford (NIH/NIAID)
"TLR signaling and macrophage metabolism"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Veronique Witko-Sarsat (Inserm, Cochin Institute, Paris)
"Role of PCNA in neutrophil survival"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Carmen Alvarez-Dominguez (IFIMAV)
"Listeria phagosomes and thier use as vaccines and signaling platforms"
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9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammasomes |
| Discussion Leader: Lynda Stuart (Massachusetts General Hospital) |
9:05 am - 9:30 am | Fayyaz Sutterwala (U. of Iowa)
"Inflammasome mediated regulation of Th17 immune responses"
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9:30 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Short talk: Christine Becker (Massachusetts General Hospital)
"A phagosome-associated Rab GTPase that interacts with caspase-1 and is important for regulating trafficking in the innate immune system"
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9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:15 am - 10:40 am | Maya Saleh (McGill U.)
"Cross regulation of apoptosis and inflammasomes"
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10:40 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Jeff Cox (U.of California, San Francisco)
"The ubiquitin ligase PARKIN is required for autophagy and host resistance to intracellular pathogens"
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11:20 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | John Kehrl (NIH/NIAID)
"How autophagy augments and limits inflammasome activity"
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12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short talk: Edward Miao (UNC Chapel Hill)
"Noncanonical inflammasome activation of caspase-11 protects against cytosolic bacteria"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Phagocytosis and Phagosomes |
| Discussion Leader: William Nauseef (U.of Iowa) |
7:35 pm - 8:00 pm | Sergio Grinstein (Hospital for Sick Children, U. of Toronto)
"Regulation of actin polymerization during phagocytosis"
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8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Nicolas Demaurex (U. of Geneva)
"STIM1-mediated calcium signaling at the endoplasmic reticulum-phagosome interface"
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8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Sergio Catz (Scripps Research Institute)
"Regulation of vesicular trafficking and fusion by Rab effectors and why it matters to the neutrophil"
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9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |