Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Efferocytosis in Inflammation Resolution
Discussion Leader: William Nauseef (University of Iowa, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
Ira Tabas (Columbia University Irving Medical Center, USA)
"Efferocytosis in Inflammation Resolution"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammatory Mechanisms
Discussion Leader: Ira Tabas (Columbia University Irving Medical Center, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Feng Shao (National Institute of Biological Sciences, Beijing, China)
"Pyroptosis: From Innate Immunity to Cancer"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Gabrielle Fredman (Albany Medical College, USA)
"New Mechanisms for Necroptotic Cell Engulfment by Macrophages"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:15 am
Ivan Zanoni (Boston Children's Hospital, USA)
"Type III Interferons as Master Regulators of the Inflammatory Process"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Nan Zhang (Washington University School of Medicine, USA)
"Connecting Specialized Gene Signature to Specialized Tissue Function in Peritoneal Macrophages"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Sourav Bhattacharya (Washington University in St. Louis, USA)
"A Role for the Resident Alveolar Macrophage NADPH Oxidase in Maintaining Alveolar Homeostasis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Alison Criss (University of Virginia, USA) and Natalie Thiex (South Dakota State University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host-Pathogen Interactions
Discussion Leader: Alison Criss (University of Virginia, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Christina Stallings (Washington University School of Medicine, USA)
"Innate Immune Responses to Mycobacterium tuberculosis Infection"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Thierry Soldati (University of Geneva, Switzerland)
"Dictyostelium as a Versatile Host Model to Study Conserved Mechanisms of Cell-Autonomous Immunity to (Myco)bacteria Infections"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Pallavi Chandra (Washington University School of Medicine in St. Louis, USA)
"The Role of Macrophage Fatty Acid Oxidation in Mycobacterium tuberculosis Pathogenesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Matthew Lawrenz (University of Louisville, USA)
"Gain of Function Approach Reveals Hidden Contributions of Yop Effectors During Yersinia pestis infection of Human Neutrophils"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocytosis
Discussion Leader: Rene Harrison (University of Toronto, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Sergio Grinstein (The Hospital for Sick Children, Canada)
"Phagosome Formation, Maturation and Resolution"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Shai Shaham (Rockefeller University, USA)
"Phagocytosis of Non-Apoptotic Dying Cells: New Players in New Pathways"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Michael Bassik (Stanford University, USA)
"High-Throughput CRISPR Screens to Identify Regulators of Phagocytosis"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Steffen Massberg (Klinikum der Universität München, Germany)
"Platelet-Phagocyte Cross-Talk: Implications for Infection and Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Meghan Morrissey (University of California, San Francisco, USA)
"CD47 Positions SIRPA to Prevent Integrin Activation and Engulfment"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiome-Phagocyte Interactions
Discussion Leader: Sergio Catz (The Scripps Research Institute, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Gretchen Diehl (Baylor College of Medicine, USA)
"Microbiota Signals to Limit Intestinal Inflammation Through Regulation of Mononuclear Phagocytes"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Ramnik Xavier (Massachusetts General Hospital / Broad Institute of MIT and Harvard, USA)
"Microbial Metabolites, Redox Sensors and Mucosal Immunity"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Frances Mercer (Cal Poly Pomona, USA)
"Neutrophils Kill the Parasite Trichomonas vaginalis Using Trogocytosis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
William Pandori (University of California, Irvine, USA)
"Regulation of IL-1β Production and Release During Toxoplasma gondii Infection of Primary Human Monocytes"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Niche Phagocytes
Discussion Leader: Stefan Linder (Medical Center Hamburg-Eppendorf, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Katherine MacNamara (Albany Medical Center, USA)
"Macrophage-Dependent Regulation of Hematopoiesis and HSC Function in Disease and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Gustavo Menezes (Federal University of Minas Gerais (UFMG), Brazil)
"Immunologic Adaptations to Life After Birth"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Menna Clatworthy (University of Cambridge, United Kingdom)
"Kidney Environment Shapes Mononuclear Phagocyte Function"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Paul Kubes (University of Calgary, Canada)
"How Neutrophils Eradicate Bacteria in Different Organs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Saumil Sethna (University of Maryland School of Medicine, USA)
"CIB2 Is Essential for Phagocytosis and Visual Function"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Homeostatic and Developmental Roles of Phagocytes
Discussion Leader: Gustavo Menezes (Federal University of Minas Gerais (UFMG), Brazil)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Dae Seok Eom (University of California, Irvine, USA)
"Macrophage Function in Long-Range Intercellular Communication"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Claudia Rival (University of Virginia, USA)
"Phosphatidylserine, Phagocytic Machinery and Fertilization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Natalie Thiex (South Dakota State University, USA)
"CRISPR/Cas9 Whole Genome Screens Identify Mediators of Lipid Droplet Formation and Degradation in Primary Murine Macrophages"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Pedro Marques (KU Leuven, Belgium)
"Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte Roles in Disease
Discussion Leader: Florence Niedergang (Institut Cochin, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Mariana Kaplan (National Institutes of Health, USA)
"Neurophils and NETs Dysregulation in Autoimmunity"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Richard Ransohoff (Third Rock Ventures, USA)
"Microglia and Neurodegeneration: An Update"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Emil Unanue (Washington University School of Medicine, USA)
"The Diverse Roles of Phagocytes in Pancreatic Islets"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Charles Serhan (Harvard University, USA)
"A Novel Pro-Resolving Vagal Reflex Uncovered with Electrical Stimulation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Slava Epelman (University Health Network, Canada)
"Single Cell RNA Sequencing Reveals a Cardioprotective Role for Self-Renewing Resident Macrophages Following Myocardial Infarction"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Aging and Other Factors Influencing Phagocytes
Discussion Leader: Charles Serhan (Harvard University, USA)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:05 pm
Dawn Bowdish (McMaster University, Canada)
"Macrophage Phagocytosis Changes with Age and Chronic Inflammation"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:40 pm
Mikael Simons (Technical University of Munich, Germany)
"The Role of Phagocytes in Myelin Repair"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Estee Kurant (University of Haifa, Israel)
"Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Christopher Hall (University of Auckland, New Zealand)
"Helping Neutrophils Run Like Clockwork: The Core Clock Gene Per2 Contributes to Neutrophil Bactericidal Activity in a Cell-Autonomous Fashion"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure