Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Tumor Myeloid Microenvironment
Discussion Leaders: Dianne Cox (Albert Einstein College of Medicine, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
Gwendalyn Randolph (Washington University in St. Louis, United States)
"Monocytes, Dendritic Cells, and Macrophages – A Migratory Journey"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innate Immunity from a Cancer Perspective
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Toby Lawrence (King's College London, United Kingdom)
"Tumor-Associated Myeloid Cells: The Good, the Bad, and the Ugly"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
David Entenberg (Einstein College of Medicine, United States)
"Primary Tumor Associated Macrophages Activate Programs of Invasion and Dormancy in Disseminating Tumor Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Robyn Klein (Washington University School of Medicine, United States)
"Post-infectious Microglia: Harnessing Phagocytosis to Protect the Brain"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Dmitry Gabrilovich (AstraZeneca, United States)
" Neutrophils and PMN-MDSC: Two-Faced Janus of Innate Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Shuvasree SenGupta (University Of Michigan, United States)
"Regulation of Neutrophil Recruitment to the Tumor Niche in Breast Cancer"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Mallary Greenlee-Wacker (Central Michigan University, United States) and Natalie Thiex (South Dakota State University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Outside Influences on Phagocyte Function
Discussion Leader: Katherine MacNamara (Albany Medical Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
John Brumell (Hospital for Sick Children, Canada)
"Listeriolysin O Induces Phagosome Stress Response"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Silvia Uriarte (University of Louisville, United States)
"A New Challenge at the Oral Mucosa: Neutrophils Coping with Emerging Oral Pathogens"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
James Vines (The University of Sheffield, United Kingdom)
"Some Wine with Your Meal? PIKfyve Drives Macropinosome/Phagosome Fusion to Aid Digestion"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jane Symington (University of California San Francisco, United States)
"Elucidating Key Interactions Between Coccidioides and Macrophages"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Cytoskeleton and Membrane Trafficking
Discussion Leader: Mallary Greenlee-Wacker (Central Michigan University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Mira Krendel (SUNY Upstate Medical University, United States)
"Actin and Myosin Cross-Talk During Phagocytosis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Adam Hoppe (South Dakota State University, United States)
"Enhancing Macrophage Phagocytosis of Cancer Cells Targeted with Therapeutic Antibodies"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Florence Niedergang (Institut Cochin, France)
"How to Build an Efficient Phagosome: Lessons from Pathogens"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Jason King (University of Sheffield, United Kingdom)
"4D Imaging Reveals New Insight into Macropinosome Formation and Closure"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Savini Thrikawala (Clemson University, United States)
"Phagocytes Prevent Invasive Growth of Aspergillus Hyphae in Zebrafish Larvae"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Phagocyte Influencers
Discussion Leader: Natalie Thiex (South Dakota State University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Daniel Irimia (Harvard Medical School, United States)
"Neutrophils Cooperate in the Biosynthesis of Lipid Mediators Driving Swarming"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Andres Hidalgo (Yale University, Spain)
"Fate and Functions of Macrophages in the Heart"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Stephania Libreros Ruiz (Harvard Medical School / Brigham and Women's Hospital, United States)
"Resolvin E4 is activated in Physiologic Hypoxia: Biosynthesis and Actions of the Newest Resolvin"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Silvia Pires (Weill Cornell Medicine/The Jill Roberts Institue for research in inflammatory bowel disease, United States)
"Role for TL1A in Innate Intestinal Inflammation and Colitis Associated Cancer"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte Plasticity
Discussion Leader: Silvia Uriarte (University of Louisville, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ruth Montgomery (Yale School of Medicine, United States)
"Multisystem Profiling Reveals Phagocyte Responses in Divergent Outcomes to Viral Infection"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
David Tobin (Duke University, United States)
"Macrophage Reprogramming in Tuberculosis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Attila Mocsai (Semmelweis University, Hungary)
"Neutrophil Signaling in Autoimmune and Inflammatory Disease Models"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Lee-Ann Allen (University of Missouri, United States)
"Metabolic Reprogramming of Neutrophils by Francisella tularensis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Tian Jin (NIAID, NIH, United States)
"How Phagocytes Acquired the Capability of Hunting and Removing Pathogens from a Human Body: Lessons Learned from Chemotaxis and Phagocytosis of Dictyostelium discoideum"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Phagocyte-Pathogen Cross-Talk
Discussion Leader: Joel Swanson (University of Michigan Medical School, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Serge Mostowy (London School of Hygiene and Tropical Medicine, United Kingdom)
"Use of Zebrafish to Study Shigella-Phagocyte Interactions"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Alison Criss (University of Virginia, United States)
"Playing with Fire: Neutrophils in the Pathogenesis of Neisseria Gonorrhoeae Infection"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Valentin Yakubenko (ETSU, Quillen College of Medicine, United States)
"The Expression of Integrin aDß2 (CD11d/CD18) on Neutrophils Promotes Macrophage Migration and Prevents the Development of Endotoxemia and Sepsis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Margarida Castro Gomes Spencer (London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom)
"Training Innate Immunity in Zebrafish Using Shigella"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammasomes and Autophagy
Discussion Leader: Daniel Irimia (Harvard Medical School, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ben Croker (UC San Diego, United States)
"IVIg Targets IL-1ß-Expressing Neutrophils in Kawasaki Disease and MIS-C"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Mauricio Terebiznik (University of Toronto at Scarborough, Canada)
"Phagosome Resolution Maintains the Degradative Capacity in Phagocytes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Eric Pearlman (University of California, Irvine, United States)
"The Underappreciated Role of Neutrophils as a Source of IL-1a and IL-1ß in Microbial Infections"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Hal Hoffman (University of California, San Diego, United States)
"The Neutrophil in Autoinflammation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Vikrant Bhosle (The Hospital for Sick Children, Canada)
"Neurorepellent SLIT2 Promotes Host Innate Immune Responses during Bacterial Infection"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporters and Environmental Effects on Phagocyte Responses
Discussion Leader: Adam Hoppe (South Dakota State University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Adriana Mantegazza (Thomas Jefferson University, United States)
"Solute Carrier Transporters Modulate Inflammasome Activity by Regulating Autophagy in Dendritic Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Spencer Freeman (The Hospital for Sick Children, Canada)
"Solute Fluxes and the Surveillance of Fluid by Resident Macrophages"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Yusuke Hirata (Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan)
"Characterization of Lipid ROS-Mediated Biological Events Coupled with NADPH Oxidases during Ferroptosis in Macrophages"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Zhichao Fan (UConn Health, United States)
"Nexinhib20 Inhibits Neutrophil Adhesion and ß2 Integrin Activation by Antagonizing Rac-1-GTP Interaction"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure