Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Signals and Forces in Leukocyte Activation
Discussion Leader: William Nauseef (University of Iowa, United States)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
Klaus Ley (Augusta University, United States)
"Beta2 Integrin Activation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
Ana-Maria Lennon-Dumenil (Institut Curie, France)
"The Response of Phagocytes to Cell Shape Changes"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte Function, Immunity and Disease
Discussion Leader: Silvia Uriarte (University of Louisville, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ivan Zanoni (Harvard Medical School - Boston Children's Hospital, United States)
"Metabolic Regulation of Macrophage Functions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Catherine 'Lynn' Hedrick (Augusta University, United States)
"Monocytes: Soldiers in Health and Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Mark Feinberg (Brigham and Women's Hospital/Harvard Medical School, United States)
"LncRNA MERRICAL In-Cis Regulates CCL3/4 and Macrophage Chemotaxis in Diabetes-Associated Atherosclerosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
Markus Sperandio (Ludwig Maximilians University Munich, Germany, Germany)
"NLRP3 Inflammasome Activation in Neutrophils"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Emanuela Bruscia (Yale University School of Medicine, United States)
"Pathological Lung Inflammation and Remodeling in Cystic Fibrosis: Are Macrophages the Culprit?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Ben Croker (UC San Diego, School of Medicine, United States)
"Neutrophils: Life After Death"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Luciane Dias-Melicio (São Paulo State University (UNESP) - Botucatu Medical School, Brazil)
"NETs in Post-COVID Patients with Thromboembolism"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Silvia Uriarte (University of Louisville, United States) and Mallary Greenlee-Wacker (Cal Poly SLO, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes in Inflammatory Disease
Discussion Leader: Florence Niedergang (Institut Cochin, France)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Marco Antonio Cassatella (University of Verona, Italy, Italy)
"Understanding the Mechanisms Whereby Slan-Positive Monocytes Kill Cancer Cells During ADCC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Veronique Witko-Sarsat (INSERM U1016-Institut Cochin, France)
"The Proliferating Cell Nuclear Antigen (PCNA) as a Versatile Regulator of Neutrophil Activation in Inflammatory Diseases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Dianne Cox (Albert Einstein College of Medicine, United States)
"Macrophages Promote Tumor Cell Extravasation Across an Endothelial Barrier Through Thin Membranous Connections"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Aleksandar Ivetic (King's College London, United Kingdom)
"Investigating the Impact of Blocking L-Selectin Shedding in Deep Vein Thrombosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Stephania Libreros Ruiz (Harvard Medical School , United States)
"Resolvin D4 Regulates Excessive Neutrophil Deployment During Infection"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Immunity, Autophagy and Cell Death
Discussion Leader: Gustavo Menezes (Federal University of Minas Gerais (UFMG), Brazil)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Mordecahy Gerlic (Tel Aviv university, Israel)
"The Trojan Horse: Two T6SS Effectors Induce Pyroptosis upon Phagocytosis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Sanja Arandjelovic (University of Virginia, United States)
"Regulation of Neutrophil-Mediated Inflammation by ELMO1"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Sofia de Oliveira (Albert Einstein College of Medicine, United States)
"Metainflammation Impacts Neutrophil Biology: Lessons from the Zebrafish"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Carlos Rosales (Universidad Nacional Autónoma de México, Mexico)
"Specific Signaling by Fc Receptors in Human Neutrophils"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Arturo Zychlinsky (Max Planck Institute for Infection Biology, Germany)
"Neutrophil Extracellular Traps"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Kim McCall (Boston University, United States)
"Coordination of Non-Apoptotic Cell Death and Clearance in the Drosophila Ovary"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Piya Ghose (The University of Texas at Arlington, United States)
"SQST-1/p62 and SKN-1/NRF2 Promote Phagocytosis Under Stress by Promoting Lysosomal Trafficking"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Migration and Differentiation in Immunity and Inflammation
Discussion Leader: Daniel Irimia (Massachusetts General Hospital, Harvard Medical School, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gustavo Menezes (Federal University of Minas Gerais (UFMG), Brazil)
"A Developmental Approach on Liver Immune and Metabolic System Under the Eyes of High Dimensional Intravital Microscopy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Carole Parent (University of Michigan, United States)
"Dissecting the Mechanisms that Regulate Neutrophil Chemotaxis and NET Release"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Balázs Enyedi (Semmelweis University, Hungary)
"Novel Biosensors for the Real-Time Measurement of LTB4 and Further Chemoattractant Gradients"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Rio Sugimura (University of Hong Kong, Hong Kong SAR China)
"PD-L1 Regulates the Development of Inflammatory Macrophages from Human Stem Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nienke Vrisekoop (Dept of Respiratory Medicine, CTI, UMCU, The Netherlands)
"In Vivo Deuterium Labeling of Neutrophil Precursors in Human Bone Marrow Identifies a Linear Conveyor Belt Structure of Neutrophil Development"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Phagocytosis in Macrophages and Dendritic Cells
Discussion Leader: Mallary Greenlee-Wacker (Cal Poly SLO, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Meghan Morrissey (University of California, Santa Barbara, United States)
"Using DNA Origami to Understand Phagocytic Signaling"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Johnathan Canton (University of Calgary, Canada)
"Apolipoprotein Control of Antigen Cross-Presentation by Classical Dendritic Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Benjamin Winer (Memorial Sloan Kettering Cancer Center and University of California San Francisco, United States)
"Excess Plasma Membrane Mechanically Regulates Functional Decision-Making in Myeloid Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Roberto Botelho (Toronto Metropolitan University, Canada)
"Determinants of Phagocytic Appetite Exhaustion and Recovery"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Sergio Grinstein (The Hospital for Sick Children, Canada)
"Quiescent Actin Dynamics Following Phagocytosis: Macrophages Hibernate After a Large Meal"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Paula Nunes-Hasler (University of Geneva, Switzerland)
"Investigating Sphingolipid Dynamics During Phagocytosis Using Novel Genetically-Encoded Fluorescent Probes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Emily Rosowski (Clemson University, United States)
"Macrophage-Mediated Intracellular and Extracellular Control of Aspergillus Fumigatus Fungal Infection in Larval Zebrafish"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microglia, Phagocytosis in the Central Nervous System
Discussion Leader: Ivan Zanoni (Harvard Medical School - Boston Children's Hospital, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Dorothy Schafer (University of Massachusetts Chan Medical School, United States)
"Phagocytosis Within Neural Circuits: A Synapse Makes for a Good Meal"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Anna Victoria Molofsky (University of California, San Francisco, United States)
"Phagocytic Type I Interferon-Responsive Microglia in Brain Development"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Amal Amer (The Ohio State University, Columbus, Ohio, United States)
"The Role of the Non-Canonical Inflammasome in Macrophages and Microglia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Dmitri Krysko (Ghent University, Belgium)
"A New Approach in Glioma Therapy: DC Vaccines Loaded with Immunogenic Lysates Induce Efficient Anti-Tumor Immunity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Clare Muir (University of Sheffield, United Kingdom)
"Deciding What to Eat; When Neutrophils Have a Taster but Not a Second Course"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Phagocytes in Host-Pathogen Interaction
Discussion Leader: Roberto Botelho (Toronto Metropolitan University, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Yan Yu (Indiana University, United States)
"Multi-Scale Spatial Organization in Pathogen-Host Interactions: From Membrane Crosstalk to Phagosome Maturation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Juhi Bagaitkar (Nationwide Children's Hospital and The Ohio State University, United States)
"Manipulating Efferocytosis: A New Role for P.gingivalis Proteases"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Christel Verollet (IPBS CNRS Toulouse France, France)
"Deciphering Mechanisms of Cell-to-Cell Transfer of HIV-1 Towards Macrophages and Their Modulation in Co-Infection with Mycobacterium Tuberculosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Jorge Galan (Yale School of Medicine, United States)
"A Cell-Intrinsic Host Defense Pathway that Controls Salmonella Intracellular Replication"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Keke Fairfax (University of Utah, United States)
"To Protect a Host: Unwinding the Mechanisms of Helminth Antigens in Reprogramming Host Myeloid Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Laurel Hind (University of Colorado Boulder, United States)
"An Infection-on-a-Chip Microfluidic Device for Investigating How Multicellular Interactions Impact the Innate Immune Response to Infection"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Elsa Bou Ghanem (Department of Microbiology & Immunology, University at Buffalo, United States)
"Neutrophils Control T Cell Responses to the Pneumococcal Conjugate Vaccine"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes, Mucosal Immunity and the Microbiota
Discussion Leader: Sanja Arandjelovic (University of Virginia, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gretchen Diehl (Memorial Sloan Kettering, United States)
"The Microbiota and Development of Intestinal Immunity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Matthew Lawrenz (University of Louisville, United States)
"Neutrophils and the Black Death: Yersinia Pestis Actively Inhibits the Synthesis of Leukotriene B4 During Infection"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Alissa Rothchild (University of Massachusetts Amherst, United States)
"Alveolar Macrophage Innate Sentinel Response to Mycobacterium tuberculosis "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Ashish Singh (University College Dublin, Ireland)
"Neutrophils Drive Mucosal Inflammation by Reprogramming Their Oxidative Repertoire"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure