Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
New Methods and Models
Discussion Leader: Claudia Rival (University of Virginia, USA)
3:45 pm - 3:55 pm
Ted Roberts (University of Bristol, United Kingdom)
"Ex Vivo Culture of Neutrophils as a Tool to Examine Neutrophil Cell Biology and Functionality"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Kathryn Wierenga (Michigan State University, USA)
"Omega-3 Fatty Acid Suppression of Silica-Induced Inflammasome Activation in a Novel Alveolar Macrophage Model"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Julien Subburayalu (University of Cambridge, United Kingdom)
"Killing Me Softly: An Unbiased Proteomic Approach to Identifying Novel 'Eat Me' Signatures on Apoptotic Neutrophils"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytosis
Discussion Leader: Pedro Marques (The Hospital for Sick Children, Canada)
7:30 pm - 7:40 pm
Paul Imbert (Peter Gilgan Centre for Research and Learning, SickKids, Canada)
"The Role of the Macrophage Glycocalyx in Phagocytosis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Catherine Buckley (University of Birmingham, United Kingdom / The Hospital for Sick Children, Canada)
"Mechanisms of Na+ Trafficking in Macropinosomes and Lysosomes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Anna D'Amico (Albany Medical College, USA)
"PKC-E and Post-Golgi Trafficking During Phagocytosis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Therese de Neergaard (Lund University, Sweden)
"Interaction-Normalized Assessment of Phagocytosis Reveals Non-Linear Igg-Fc Receptor Engagement Dependency"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Saumil Sethna (University of Maryland School of Medicine, USA)
"CIB2 Is Essential for Phagocytosis and Visual Function"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Viktória Szeifert (Semmelweis University, Hungary)
"The Role of Calcium Signaling in Formation and Function of Neutrophilic Granulocyte Derived Extracellular Vesicles"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Ziv Roth (The Hospital for Sick Children, Canada)
"Differential Effect of M-CSF vs. GM-CSF on Macrophage Polarization"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fernando Montano Rendon (Hospital for Sick Children / University of Toronto, Canada)
"Phagosome Resolution Is Mediated by Contacts with the ER and PI4P Down Regulation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Host-Pathogen Interaction
Discussion Leader: Gregory Olson (University of Washington, USA)
9:00 am - 9:10 am
Tobias Dallenga (Research Center Borstel, Germany)
"Neutrophils as Targets for Host-Directed Therapy Against Tuberculosis"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Basel Abuaita (University of Michigan Medical School, USA)
"Mitochondria-Derived Vesicles Deliver Antimicrobial Payload to Control Phagosomal Bacteria"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Rachel Kinsella (Washington University in St. Louis, USA)
"Investigating the Mechanism by Which ATG5 Controls Inflammation During Mycobacterium tuberculosis Infection"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
William Pandori (University of California, Irvine, USA)
"Regulation of IL-1β Production and Release During Toxoplasma gondii Infection of Primary Human Monocytes"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Alissa Rothchild (Seattle Children's Research Institute, USA)
"Alveolar Macrophages Up-Regulate a Non-Classical Innate Response to Mycobacterium tuberculosis Infection In Vivo "
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Annica Stull-Lane (University of California, Davis, USA)
"NRAMP1/SLC11A1 Contributes to the Antimicrobial Response of Neutrophils"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Johannes Westman (The Hospital for Sick Children, Canada)
"Regulation of Phagosomal Size and Integrity During Infection"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Glenn Walpole (The Hospital for Sick Children, Canada)
"Inactivation of Rho Gtpases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Modulates Phagosome Maturation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Phagocytes in Disease
Discussion Leader: Fernando Montano Rendon (Hospital for Sick Children / University of Toronto, Canada)
1:30 pm - 1:40 pm
Sabine Arve (Lund University, Sweden)
"Neutrophil Extracellular Traps Serve as Antigens for Antinuclear Antibodies in Juvenile Idiopathic Arthritis"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Mar Bosch Queralt (German Centre for Neurodegenerative Diseases, Germany)
"Impaired Lipid Handling by Phagocytes Prevents Myelin Regeneration in the Central Nervous System"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Caterina Di Pietro (Yale University, USA)
"Pharmocological Induction of the HO-1/CO Pathway in Macrophages Ameliorates Cystic Fibrosis Lung Hyper-Inflammation"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Hasan Oz (Yale School of Medicine, USA)
"Dysregulated Dynamics of Monocyte-Derived Macrophages During Pulmonary Chronic Inflammation Contribute to CF Airway Remodeling"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
