Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Cell Growth and Signalling
Discussion Leader: Dale Allen (The Scripps Research Institute, United States)
3:45 pm - 3:55 pm
Kevin Wanniarachchi (South Dakota State University, United States)
"CRISPR-Cas9 Whole Genome Screens Classify Genes Regulating Growth in Primary Bone-Marrow Derived Macrophages in-vitro"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Sina Ghasempour (The Hospital for Sick Children, Canada)
"Gain-of-Function Variants in SYK that Cause Immune Dysregulation: Investigating the Impact of an Active Tyrosine Kinase on Myeloid Cell Function"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Emmet Francis (UC Davis, United States)
"Assessing the Causes and Effects of Calcium Bursts During Neutrophil Phagocytosis"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Host-Pathogen Interactions, Inflammation and Disease
Discussion Leader: Lauren Hein (University of Michigan, United States)
7:30 pm - 7:40 pm
Bruno Menarim (Gluck Equine Research Center, United States)
"Molecular Effectors of Bone Marrow Mononuclear Cell-mediated Resolution of Synovitis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Havisha Honwad (University of Massachusetts Medical School, United States)
"A Novel NOX/PHOX CD38 NAADP TFEB Axis Important for Macrophage Activation During Bacterial Phagocytosis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Aimee Potter (University of Virginia, United States)
"Dual Species Transcriptomics Reveals Core Metabolic and Immunologic Processes in the Interaction Between Primary Human Neutrophils and Neisseria Gonorrhoeae"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Ann-Kathrin Zimmermann (Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Germany)
"Functional Analysis of Macrophage-Derived Extracellular Vesicles Triggered by Aspergillus Fumigatus"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Chris Tanner (Clemson University, United States)
"Determining Importance of Rac2 in the Macrophage Response to Aspergillus fumigatus Infection"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Sydney Escobar (University of Missouri, United States)
"Francisella Tularensis-infected Neutrophils as Trojan Horses for Infection and Reprogramming of Macrophages"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Shuying Xu (Tufts University Graduate School of Biomedical Sciences, United States)
"Age-Related Disruption of Airway Epithelium by Pneumolysin and Neutrophil Transmigration During S. pneumoniae Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kelley Cooper (University of Louisville, United States)
"Atypical Efferocytosis of Live Neutrophils Sustains Inflammation During P. Gingivalis Infection"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mechanisms of Phagocytosis, Macropinocytosis and Recruitment
Discussion Leader: Emmet Francis (UC Davis, United States)
9:00 am - 9:10 am
Anna D'Amico (Albany Medical College, United States)
"A Novel FcGammaR to Golgi Relay for PKC-e dependent Vesicular Trafficking During Phagocytosis"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Sarah Chadwick (The Hospital for Sick Children, Canada)
"Two Pore Channels are not Required for Phagocytosis but Orchestrate the Final Stages of Phagosome Resolution by Controlling Endomembrane Tension"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
James Vines (The University of Sheffield, United Kingdom)
"Some Wine With Your Meal? PIKfyve Drives Macropinosome/Phagosome Fusion to Aid Digestion"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Jingze Wu (Hospital for Sick Children, Canada)
"Concentrating Luminal Chloride Supports the Degradative Capacity of Phagosomes and Lysosomes Independently from pH"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Joanna Zareba (University of Zurich, Switzerland)
"Investigating the Role of the Gastrosome: a New Compartment Involved in Phagocytosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Allison Cohen (University of California, San Francisco, United States)
"Genome Scale CRISPR Screening"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Rosemary Bayless (North Carolina State University, United States)
"Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Manon Depierre (Institut Cochin, France)
"Mechanotransduction in Integrin-Mediated Phagocytosis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Phagocytes: Effector Cells with Roles Beyond Phagocytosis
Discussion Leader: Kelley Cooper (University of Louisville, United States)
1:30 pm - 1:40 pm
Aminata Coulibaly (West Virginia University, United States)
"Neutrophils as Neuromodulators, a Non-Canonical Role"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Mikaela Brentlinger (Texas Tech University Health Sciences Center El Paso Paul L. Foster School of Medicine, United States)
"Glioblastoma Gangliosides Induce NF-kB Activation and M2 Macrophage Polarization"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Kasey Keever (East Tennessee State University, United States)
"Cholinergic Signaling Regulates Macrophage Migration During Acute Inflammation via a7 Nicotinic Acetylcholine Receptor"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Lauren Hein (University of Michigan, United States)
"The Role of TGF-ß Signaling in Neutrophil Recruitment to the Breast Tumor Niche"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
