| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEY NOTE TALKS: CHEMICAL-GENETIC APPROACHES TO SIGNAL TRANSDUCTION |
| Discussion Leader: Natalie Ahn (University of Colorado, Boulder, CO) |
| 7:30 pm - 8:20 pm | Roger Tsien, AMC Lecturer (University of California, San Diego, La Jolla, CA)
"Breeding molecules to spy on cells" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Kevan Shokat (University of California, San Francisco, CA)
"Chemical genetic analyses of diverse protein kinases" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Welcome Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | DYNAMICS OF CELL SIGNALING I |
| Discussion Leader: Melanie Cobb (University of Texas Southwestern, Dallas, TX) |
| 9:00 am - 9:25 am | Melanie Cobb (University of Texas Southwestern, Dallas, TX)
"WNK and its role in hypertension" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Barbara Graves (University of Utah, Salt Lake City, UT)
"Phosphorylation and dynamic allostery" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Marsha Rosner (University of Chicago, Chicago, IL)
"Raf kinase inhibitory protein regulates Aurora B kinase and the spindle checkpoint via MAP kinase" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | John Hancock (University of Queensland, Brisbane, Australia)
"Ras plasma membrane signaling platforms" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 pm | Alexandra Newton (University of California, San Diego, La Jolla, CA)
"PHLPPing the Switch in Akt Signalling" |
| 11:45 pm - 11:55 pm | Discussion |
| 11:55 am - 12:20 pm | J. Silvio Gutkind (National Institutes of Health, Bethesda, MD)
"Viral hijacking of G-protein signaling networks" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW TECHNOLOGIES FOR SIGNALING RESEARCH |
| Discussion Leader: Douglas Lauffenburger (MIT, Cambridge, MA) |
| 7:30 pm - 7:55 pm | Douglas Lauffenburger (MIT, Cambridge, MA)
"Modeling of signal-response cascades" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Roland Annan (GlaxoSmithKline, King of Prussia, PA)
"Mass spectrometry-based tools for understanding complex patterns of protein phosphorylation" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Michael Yaffe (MIT, Cambridge, MA)
"Dynamics of kinase-substrate interactions" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Neal Zondlo (Lammot Dupont Labs, Newark, DE)
"Phosphorylation-dependent protein structure and protein design" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DEVELOPMENTAL AND DISEASE SIGNALING PATHWAYS |
| Discussion Leader: Xuedong Liu (University of Colorado, Boulder, CO) |
| 9:00 am - 9:25 am | Xuedong Liu (University of Colorado, Boulder, CO)
"Non-canonical Smad signaling" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Xi He (Harvard Medical School, Boston, MA)
"Molecular mechanisms of Wnt signaling" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Larry Feig (Tufts University, Boston, MA)
"The environment vs. genetics in controlling the significance of Ras signaling in the brain" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Joan Massague (Memorial Sloan-Kettering Cancer Center, New York, NY)
"G1 cell-cycle control and cancer" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 pm | Anne Brunet (Stanford University, Stanford, CA)
"FOXO transcription factors in aging" |
| 11:45 pm - 11:55 pm | Discussion |
| 11:55 am - 12:20 pm | Frank Slack (Yale University, New Haven, CT)
"Regulation of Ras by the let-7 microRNA family" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MECHANISMS OF HOST-PATHOGEN INTERACTIONS |
| Discussion Leader: Kim Orth (U. Texas Southwestern, Dallas, TX) |
| 7:30 pm - 7:55 pm | Kim Orth (Texas Southwestern, Dallas, TX)
"Molecular mechanism for Yersinia YopJ inhibition of innate immune response" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Jack Dixon (University of California, San Diego, La Jolla, CA)
"A family of bacterial effector proteins that mimic the function of GTPases" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Daniel Kalman (Emory University, Atlanta, GA)
"Abl-family tyrosine kinases mediate pathogenesis of poxviruses and pathogenic E. coli." |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Matthew Good (University of California, San Francisco, San Francisco, CA)
"The structure of kinase docking and scaffolding interactions and their role in specifying MAPK pathway information flow" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DYNAMICS OF CELL SIGNALING II |
| Discussion Leader: Jean Wang (University of California, San Diego, La Jolla, CA) |
| 9:00 am - 9:25 am | Jean Wang (University of California, San Diego, La Jolla, CA)
"Signaling through Abl: Co-inhibition enables diverse biological functions" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Susan Taylor (University of California, San Diego, La Jolla, CA)
"The PKA haloenzyme" |
| 10:00 am- 10:10 am | Discussion |
| 10:10 am -10:20 am | Natalia Riobo (Johns Hopkins University, Baltimore, MD)
"Activation of heterotrimeric Gi proteins by smoothened" |
| 10:20 am -10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | JoAnn Trejo (University of North Carolina, Chapel Hill, NC)
"Protease-activated receptor signaling and mechanisms of endocytic sorting" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 pm | Henrik Dohlman (University of North Carolina, Chapel Hill, NC)
"G-protein signaling networks in yeast" |
| 11:45 pm - 11:55 pm | Discussion |
| 11:55 am - 12:20 pm | Richard Carthew (Northwestern University, Evanston, IL)
"RNAi, microRNA, and gene regulation in Drosophila" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:15 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | TARGETING AND CELL POLARITY |
| Discussion Leader: Jeremy Thorner (University of California, Berkeley, CA) |
| 7:30 pm - 7:55 pm | Jeremy Thorner (University of California, Berkeley, CA)
"DEP domains link an RGS protein to its cognate G-protein-coupled receptor" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Richard Firtel (University of California, San Diego, La Jolla, CA)
"Directional sensing and cell polarization through Ras signaling" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Fred Chang (Columbia University)
"Regulating cell polarity during the fission yeast cell cycle" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Eric Witze (University of Colorado, Boulder , CO)
"Control of receptor polarity by noncanonical Wnt signaling" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METABOLIC STATUS AND NUTRIENT SENSING |
| Discussion Leader: Kun-liang Guan (University of Michigan, Ann Arbor, MI) |
| 9:00 am - 9:25 am | Kun-liang Guan (University of Michigan, Ann Arbor, MI)
"Dysregulation of the TSC-mTOR pathway in disease" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Gerald Shulman (HHMI, Yale University School of Medicine, New Haven, CT )
"Mechanisms of insulin resistance and links with inflammation" |
| 10:00 am- 10:10 am | Discussion |
| 10:10 am -10:20 am | Reuben Shaw (Salk Institute, La Jolla, CA)
"Regulation of tumorigenesis and metabolism by the LKB1 kinase" |
| 10:20 am -10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Erin O’Shea (Harvard University, Cambridge, MA)
"Cellular nutrient homeostasis" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Ben Neel (Beth Israel Deconess Medical Center, Boston, MA)
"Tyrosine phosphatases in body mass regulation and glucose homeostasis" |
| 11:45 pm - 11:55 pm | Discussion |
| 11:55 am- 12:20 pm | Marian Carlson (Columbia University, New York, NY)
"Snf1/AMPK pathways, nutrient signals, and metabolic stress: insights from yeast" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRESS AND DISEASE |
| Discussion Leader: Gary Johnson (University of North Carolina, Chapel Hill, NC) |
| 7:30 pm - 7:55 pm | Gary Johnson (University of North Carolina, Chapel Hill, NC)
"Cerebral cavernous malformations: A disease resulting from the mutation of scaffolding proteins regulating MEKK3 and p38" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Roger Davis (University of Massachusetts Medical School, Worcester, MA)
"Signal transduction by JNK" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Zhijian James Chen (U. Texas Sourthwestern, Dallas, TX)
"The novel functions of ubiquitination in NF-κB signaling" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Yajun Xu (Millennium Pharmaceutical, Inc., Cambridge, MA)
"Discovery of a small molecule IB kinase (IKK2) inhibitor for rheumatoid arthritis" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
