This conference, formerly known as "Second Messengers and Protein Phosphorylation" has been a premier venue for the presentation of new discoveries in signal transduction since 1970. Meeting topics cover networks of intracellular signaling pathways from a mechanistic viewpoint, focusing on hormone and neurotransmitter receptors, G proteins (large and small), second messengers, and protein kinases.

Presentations highlight cutting edge discoveries by protein covalent modifications, activators and inhibitors of G protein signaling, and control by small molecule effectors. Together these describe how cells control diverse cellular responses of proliferation, cell cycle, transformation, differentiation, morphogenesis, and metabolic homeostasis.

Our goal is to bring together an outstanding and diverse group of scientists from government, academic and industry labs, all at the forefront of research. In particular we wish to welcome participation by younger scientists and students.

The University of New England became the new site for this meeting in 2005, after many years at Kimball Union Academy. The accommodations are very comfortable, with air conditioned private rooms, each equipped with ethernet. There is a beach within walking distance, and superb athletic facilities on site including an indoor pool and fully equipped gym.