SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | MAPK Regulated Signaling Networks: Emerging Paradigms |
| Discussion Leader: Natalie G. Ahn (University of Colorado) |
7:45 pm - 8:10 pm | Roger Davis (University of Massachusetts) "Signal Transduction by Stress-activated MAP kinases" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Natalie G. Ahn (University of Colorado) "Profiling Targets of MAP kinases" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Angel R. Nebreda (Centro Nacional de Investigacions Oncologicas) "Signal Integration by p38 MAP kinases" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Signaling Networks in Nutrient Sensing and Metabolism (Part 1) |
| Discussion Leader: Joseph Avruch (Massachusetts General Hospital/Harvard Medical School) |
9:00 am - 9:25 am | Brendan D. Manning (Harvard School of Public Health) "Control of mTOR complexes by the TSC1-TSC2 complex" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Kun Liang Guan (University of California, San Diego) "TSC-mTOR in nutrient response" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | John Blenis (Harvard Medical School) "mTOR, S6K1 and Translational Control" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Joseph Avruch (Massachusetts General Hospital / Harvard Medical School) "Upstream and Downstream of mTOR complex 1" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Sabita Sankar (Celgene) "mTOR kinase Inhibitors Exhibit Properties that Distinguish them from Rapamycin" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Elizabeth Goldsmith (UT Southwestern Medical School) "Unique Autoinhibitory Dimers in MAP2Ks an MAP4Ks" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling Networks in Nutrient Sensing and Metabolism (Part 2) |
| Discussion Leader: Morris J. Birnbaum (University of Pennsylvania School of Medicine) |
7:30 pm - 7:55 pm | David M. Sabatini (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology) "Regulation of growth by the mTOR pathway and essential metabolic genes in cancer" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Morris J. Birnbaum (University of Pennsylvania School of Medicine) "New models for old problems in the insulin-dependent control of metabolism" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Marsha Rosner (University of Chicago) "Raf Kinase Inhibitory Protein suppresses a breast cancer metastasis signaling cascade involving LIN28 and let-7" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Gunnar Shulte (Karolinska Institute) "The role of beta-arrestin for WNT/Frizzled signaling" |
9:15 pm - 9:20 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signal Integration, Imaging and Modeling (Part 1) |
| Discussion Leader: Morag Park (McGill University Health Centre) |
9:00 am - 9:25 am | Yossi Yarden (The Weizmann Institute of Science) "RTK signaling: systemic controls and relevance to cancer" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Morag Park (McGill University Health Centre) "Met receptor tyrosine kinase: intracellular trafficking, signalling and transformation" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Ravi Iyengar (Mount Sinai School of Medicine) "Spatial models of signaling component microdomain dynamics in cells" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Klarisa Rikova (Cell Signaling Technology) "Surveying Signaling Space: Alterations in Disease" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Tom Graeber (UCLA) "Reconstruction of the Bcr-Abl and Src family kinase network in leukemia through global phospho proteomics" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Julie Gavard (Institut Cochin) "VE-cadherin endocytosis by a Rac-dependent signaling axis controls endothelial permeability" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signal Integration, Imaging and Modeling (Part 2) |
| Discussion Leader: Tamas Balla (National Institutes of Health) |
7:30 pm - 7:55 pm | Michiyuki Matsuda (Kyoto University) "Spatiotemporal regulation of Rac1 and Rab5 during phagocytosis of apoptotic cells" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jin Zhang (The Johns Hopkins University School of Medicine) "Dynamic Visualization of Signaling Activities in Living Cells" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Tamas Balla (National Institutes of Health) "Imaging and manipulating signal transduction events with novel molecular tools" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Ora Bernard (St Vincent's Institute) "The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Cellular Architecture |
| Discussion Leader: Dafna Bar-Sagi (New York University School of Medicine) |
9:00 am - 9:25 am | Martin A. Schwartz (University of Virginia) "Integrin regulation of growth factor signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dafna Bar-Sagi (New York University School of Medicine) "Ras signaling: a bird's eye view" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Shuh Narumiya (Kyoto University Faculty of Medicine) "Rho-mDia pathway, Src and cell transformation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Senthil K. Muthuswamy (Cold Spring Harbor Laboratory) "Cell polarity pathways and transformation of mammary epithelial cells" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | T. Kendall Harden (University of North Carolina School of Medicine) "G protein-mediated regulation of phospholipase C" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | KEYNOTE LECTURES- Protein Kinase Siglanling - From Atomic to Genomic Views |
| Discussion Leader: Jean Y.J. Wang (University of California, San Diego) |
7:30 pm - 8:20 pm | John Kuriyan (University of California, Berkeley) "Allosteric Mechanisms in the Regulation of the Ras and the EGF Receptor" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Tony Hunter (Salk Institute for Biological Studies) "The kinome turns twenty one" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Inflammation and Stress (Part 1) |
| Discussion Leader: Melanie H. Cobb (The University of Texas Southwestern Medical Center at Dallas) |
9:00 am - 9:25 am | Michael Karin (University of California, San Diego) "Signaling by inflammatory and innate immune receptors: mechanisms and role in disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Zheng-Gang Liu (National Institutes of Health) "The Role of ROS in TNF-induced Cell death" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Anning Lin (The University of Chicago) "Wiring JNK Signaling Circuitry in Inflammation by NF-kB and SMORs" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Melanie Cobb (The University of Texas Southwestern Medical Center at Dallas) "Protein kinase involved in osmotic and oxidative stress" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Michael B. Yaffe (Massachusetts Institute of Technology) "Re-wiring of Cell Cycle Checkpoint Kinase Signaling in Cancer" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling Networks in Inflammation and Stress (Part 2) |
| Discussion Leader: Gary L. Johnson (University of North Carolina School of Medicine) |
7:30 pm - 7:55 pm | Rick Neubig (University of Michigan Medical School) "Probing G protein function in vivo with RGS insensitive Galpha subunit mutants" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Matthias P. Wymann (University of Basel) "Phosphoinositide 3-kinase - integrator and discriminator in allergy" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Gary L. Johnson (University of Michigan Medical School) "Function of MAPK Signaling Networks from Stem Cells to Metastasis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |