SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | APPROACHES TO UNDERSTAND THE PHOSPHOPROTEOME |
| Discussion Leader: Gary L. Johnson (University of North Carolina School of Medicine) |
7:40 pm - 8:10 pm | Gary L. Johnson (University of North Carolina School of Medicine)
"Quantitative Profiling of Kinome Behavior In Response To Molecularly Targeted Kinase Inhibitors" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Anne-Claude Gingras (Samuel Lunenfeld Research Institute at Mount Sinai Hospital)
"Charting kinase and phosphatase interactomes" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Ben E. Turk (Yale University, School of Medicine)
"Large scale analysis of protein kinase phosphorylation site specificity" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | SPATIAL AND TEMPORAL REGULATION OF CELL SIGNALING |
| Discussion Leader: Tony Hunter (Salk Institute for Biological Studies) |
9:00 am - 9:30 am | Tony Pawson (Samuel Lunenfeld Research Institute at Mount Sinai Hospital)
"Proteomic and function analysis of bidirectional cell signaling" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Short Talk: Xinxin Gao (Johns Hopkins University)
"PI3K/Akt Signaling Activation is Regulated by Plasma Membrane Microdomains" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | John D. Scott (University of Washington)
"Cell Signaling in Space and Time" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | James E. Ferrell, Jr. (Stanford University School of Medicine) |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Tony Hunter (Salk Institute for Biological Studies)
"Phosphorylation in cancer, the DNA damage response, and ubiquitination" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (A through L, by last name of presenter) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EMERGING SIGNALING NETWORKS: Growth Factor Pathways |
| Discussion Leader: Benjamin G. Neel (Ontario Cancer Institute) |
7:30 pm - 8:00 pm | Morris J. Birnbaum (University of Pennsylvania)
"Regulation of Hepatic Metabolism by Insulin" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Alexandra C. Newton (University of California at San Diego)
"Progressing Through the Alphabet: Signaling by Protein Kinases B, C, and D" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Benjamin G. Neel (Ontario Cancer Institute)
"Mouse models for diseases of the Ras/Mapk pathway" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMERGING SIGNALING NETWORKS: Nutrient and Energy Sensing |
| Discussion Leader: Reuben J. Shaw (Salk Institute for Biological Studies) |
9:00 am - 9:30 am | John Blenis (Harvard Medical School)
"mTOR, translation and metabolism" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Short Talk: Jessica L. Yecies (Harvard School of Public Health)
"Control of cellular metabolism downstream of mTOR complex 1" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | David Sabatini (Massachusetts Institute of Technology)
"Control of growth by the mTOR pathway" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Short Talk: Richard Lamb (University of Alberta)
"Nutrient control of mTOR and immunity" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Short Talk: Kathleen A. Martin (Yale University)
"The mTORC1 pathway regulates the GATA-6 transcription factor in vascular smooth muscle cells" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Reuben J. Shaw (Salk Institute for Biological Studies)
"LKB1 dependent signaling controls cell growth and metabolism" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (A through L, by last name of presenter) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE PRESENTATIONS: Molecular Dissection of Kinase Signaling |
| Discussion Leaders: Jin Zhang (Johns Hopkins University, School of Medicine) and Brendan D. Manning (Harvard University, School of Public Health) |
7:30 pm - 8:15 pm | Susan S. Taylor (University of California at San Diego)
"Signaling by PKA" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Michael B. Yaffe (Massachusetts Institute of Technology)
"Protein Kinase Signaling Networks in Inflammation and Cancer" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMERGING SIGNALING NETWORKS: Oncogenes and tumor suppressors |
| Discussion Leader: Dafna Bar-Sagi (NYU Medical School) |
9:00 am - 9:30 am | Natalie G. Ahn (University of Colorado at Boulder)
"A new route to cell polarity by Wnt signaling" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Short Talk: Yardena Samuels (National Institutes of Health)
"Analysis of the Tyrosine Kinome in Melanoma Reveals Recurrent Mutations in ERBB4" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Dafna Bar-Sagi (NYU Medical School)
"The signaling landscape of Ras Oncogene" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Karen Cichowski (Brigham and Women's Hospital / Harvard Medical School)
"New Mechanisms of Ras Activation in Cancer" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | J. Silvio Gutkind (National Institutes of Health)
"G protein-Signaling Networks in Cancer: A Synthetic Biology Approach" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (M through Z, by last name of presenter) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | MOLECULAR BASIS OF PHOSPHORYLATION-REGULATED SIGNALING |
| Discussion Leader: John Tesmer (University of Michigan) |
7:30 pm - 8:00 pm | John J.G. Tesmer (University of Michigan)
"Structure and Function of G protein-Coupled Receptor Kinases" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Short Talk: Jonathan D. Violin (Trevena Inc)
"Precision pharmacology: selective activation of a beta-arrestin signaling pathway with an Angiotensin II type 1 receptor biased ligand" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Short Talk: Andrew Tobin (University of Leicester)
"Phosphorylation of M3-muscarinic receptor mediates insulin secretion and glucose homeostasis via a PKD1-dependent pathway" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Heng Zhu (Johns Hopkins University)
"Towards construction of a human phosphorylome" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMERGING SIGNALING NETWORKS: Stress Responses |
| Discussion Leader: David Ron (NYU School of Medicine, Skirball Institute) |
9:00 am - 9:30 am | David Ron (NYU School of Medicine, Skirball Institute)
"New insight into signaling by IRE1 in the Unfolded Protein Response" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Short Talk: Eric L. Weiss (Northwestern University)
"An Ndr/LATS signaling system links mitotic exit to cell morphogenesis control" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Melanie H. Cobb (UT Southwestern Medical Center at Dallas) |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Jean Y. Wang (University of California at San Diego)
"Regulation of Co-Transcriptional RNA Processing by DNA Damage-Induced Tyrosine Phosphorylation of RNA Polymerase II-C-terminal Repeated Domain" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Grahame Hardie (University of Dundee)
"Regulation of AMP-activated protein kinase by multiple upstream inputs" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (M through Z, by last name of presenter) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TARGETING KINASES AND PHOSPHATASES FOR THE TREATMENT OF DISEASE |
| Discussion Leader: Philip A. Cole (Johns Hopkins University, School of Medicine) |
7:30 pm - 8:00 pm | Philip A. Cole (Johns Hopkins University, School of Medicine)
"Chemical and enzymatic analysis of protein phosphorylation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Dustin Maly (University of Washington)
"Small-Molecule Probes of Protein Kinase Dynamics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Zhong-Yin Zhang (Indiana University School of Medicine)
"Targeting Protein Tyrosine Phosphatases for Therapeutic Development" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |