SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Structural Studies of Signaling |
7:40 pm - 7:45 pm | Discussion Leader: John Sondek (University of North Carolina at Chapel Hill) |
7:45 pm - 8:10 pm | Roger Sunahara (University of Michigan)
"Structural and functional analysis of the interactions of GPCRs with G proteins" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Jan Steyaert (Vrije Universiteit Brussel)
"Nanobodies for the structural investigation of transmembrane signaling" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Steve Gamblin (MRC National Institute for Research)
"Structural and functional studies on AMP activated protein kinase: cellular energy sensor and regulator" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Protein Kinase Signaling Networks |
9:00 am - 9:05 am | Discussion Leader: Melanie H. Cobb (U. of Texas Southwestern Medical Center) |
9:05 am - 9:25 am | Melanie H. Cobb (University of Texas Southwestern Medical Center)
"The trail of nutrient sensing mechanisms in pancreatic beta cells and beyond" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Zheng (John) Fu (University of Virginia)
"Mechanistic insights into regulation and function of intestinal cell kinase" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:20 am - 10:40 am | Rebecca Berdeaux (University of Texas Health Science Center at Houston)
"Temporal regulation of SIK1 during myogenesis" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:10 am | Richard G. Fehon (University of Chicago)
"Upstream regulation of the Hippo growth control pathway" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Forest M. White (Massachusetts Institute of Technology)
"Quantitative analysis of signaling networks to connect genotype with phenotype" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Lawrence Lum (University of Texas Southwestern Medical Center)
"Kinases, GPCRs, and the primary cilium in developmental signaling networks" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Biophysical Approaches for the Study of Signal Transduction |
7:30 pm - 7:35 pm | Discussion Leader: Thomas P. Sakmar (Rockefeller University) |
7:35 pm - 8:00 pm | Thomas P. Sakmar (Rockefeller University)
"Probing GPCR signaling with genetically-encoded non-natural amino acids"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Wayne Hubbell (University of California, Los Angeles)
"Monitoring functional protein dynamics with site directed spin labeling" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Jin Zhang (Johns Hopkins University)
"Spatiotemporal regulation of protein kinases in living cells" |
9:10 pm - 9:20 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signal Transduction and Disease |
9:00 am - 9:05 am | Discussion Leader: Patrick Casey (Duke University) |
9:05 am - 9:30 am | Silvio Gutkind (National Institutes of Health)
"Novel signaling circuitries and the mutational landscape of G proteins and GPCRs in cancer" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Kirill Martemyanov (Scripps Florida)
"Orphan receptors GPR158/179 are novel modulators of G protein signaling" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Krzysztof Palczewski (Case Western Reserve University)
"Organization of rhodopsin in the disk membranes: genetic analysis" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Gerald W. Dorn II (Washington University)
"Crosstalk between Gq-dependent PKC and Gq-independent GRK/arrestin signaling in cardiac hypertrophy" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Stefan Offermanns (Max Planck Institute for Heart and Lung Research)
"G-protein mediated signalling in cardiovascular diseases" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lipid Mediated Signal Transduction |
7:30 pm - 7:35 pm | Discussion Leader: H. Alex Brown (Vanderbilt University) |
7:35 pm - 8:00 pm | Joan Heller Brown (University of California, San Diego)
"RhoA and phospholipid regulated signaling in models of cell injury" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Jon M. Backer (Albert Einstein College of Medicine)
"Regulation of class IA PI 3-kinases: news about beta" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Sarah Spiegel (Virginia Commonwealth University)
"The ins and the outs of sphingosine-1-phosphate in inflammation and cancer" |
9:10 pm - 9:20 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heterotrimeric G Protein Signaling Networks |
9:00 am - 9:05 am | Discussion Leader: John Hepler (Emory University) |
9:05 am - 9:30 am | Alan V. Smrcka (University of Rochester Medical Center)
"Phospholipase C signaling networks in physiology and disease" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Stephen R. Sprang (University of Montana)
"The nucleotide exchange factor Ric-8A induces a heterogeneous, dynamic state of Gαi1" |
10:00 am - 10:05 am | Discussion |
10:05 am | Group Photo / Coffee Break |
10:40 am - 11:05 am | Carmen W. Dessauer (University of Texas Health Science Center at Houston)
"Sensitization of GPCR signaling by anchored adenylyl cyclase complexes" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Henrik G. Dohlman (University of North Carolina at Chapel Hill)
"Metabolic control of G protein signaling in yeast" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Diomedes Logothetis (Virginia Commonwealth University)
"Hetrotrimeric G protein signaling to GIRK channels" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Keynote Lectures: When G Proteins and Kinases Converge |
7:30 pm - 7:35 pm | Discussion Leader: John J. Tesmer (University of Michigan) |
7:35 pm - 8:15 pm | John Kuriyan (University of California, Berkeley)
"Structural mechanisms in EGF activation" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Kun-Liang Guan (University of California, San Diego)
"Regulation and function of the Hippo-YAP signaling pathway" |
9:10 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Translational Approaches in Signal Transduction |
9:00 am - 9:05 am | Discussion Leader: Ben Turk (Yale University) |
9:05 am - 9:30 am | Bryan L. Roth (University of North Carolina at Chapel Hill)
"Chemical and synthetic biology meets GPCRs: translational implications" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Daisuke Urano (University of North Carolina at Chapel Hill)
"Phosphorylation-dependent receptor endocytosis initiates plant G protein signaling" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Ben Turk (Yale University)
"Motif-based identification of protein kinase substrates" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Richard Neubig (University of Michigan)
"Rho/MKL-regulated gene transcription in melanoma" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Stefan Knapp (University of Oxford)
"Structure based strategies for the selective targeting of protein kinases" |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of Kinase and G Protein Pathways |
7:30 pm - 7:35 pm | Discussion Leader: Mark von Zastrow (University of California, San Francisco) |
7:35 pm - 8:00 pm | Anton Bennett (Yale University)
"Signaling by mitogen-activated protein kinase phosphatases in health and disease" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Maurine E. Linder (Cornell University)
"A novel posttranslational processing pathway for CAAX-motif proteins" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Mark von Zastrow and Roshanak Irannejad (University of California, San Francisco)
"Effects of endocytosis on signaling mediated by heterotrimeric G proteins" |
9:10 pm - 9:20 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |