SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Carmen Dessauer (UTHSC Houston) |
7:40 pm - 8:10 pm | Frank McCormick (UCSF)
"Ras"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | John Scott (University of Washington)
"Guiding Signals Through Anchored Enzyme Complexes"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Michael Sussman (University of Wisconsin, Madison)
"Plant Kinases and Receptors: Life Without Mobility"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Kinases and G Proteins in Development |
| Discussion Leader: Carol Lange (University of Minnesota) |
9:00 am - 9:25 am | Joe Avruch (Harvard Medical School)
"The Mst1/Mst2 Kinases - The Hippo Pathway and More"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Swathi Arur (M.D. Anderson Cancer Center)
"ERK Substrate Networks During Germ Cell Development"
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10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Stacey Ogden (St. Jude's CRH)
"Control of Smoothened Signal Induction"
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10:35 am - 10:45 am | Discussion |
10:45 am | Coffee Break |
11:00 am - 11:25 am | Saikat Mukhopadhyay (UT Southwestern Medical Center)
"GPCRs, Hedgehog Signaling, and the Primary Cilium"
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11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Carol Lange (University of Minnesota)
"Noncanonical Actions of Progesterone Receptor Modifications"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Keqiang Xie (Scripps Florida)
"Neurofibromin Is an Effector and Regulator of GPCR Signaling in the Nervous System" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stem Cell Signaling |
| Discussion Leader: Rebecca Berdeaux (UT Health Science Center at Houston) |
7:30 pm - 7:50 pm | Anne Brunet (Stanford)
"Epigenetic Regulation of Stem Cell Maintenance and Rejuvenation"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Yukiko Gotoh (University of Tokyo)
"Neural Stem Cell Development"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Christophe Frémin (University of Montreal)
"Redundant Functions of ERK1 and ERK2 MAPKs in Development"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Rebecca Berdeaux (UT Health Science Center at Houston)
"Regulation and Function of SIK1 in Myogenesis and Metabolism"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Kinases and G Proteins Controlled by Pathogens and Stress |
| Discussion Leader: Jessie English (DFCI, Belfer Institute, HMS) |
9:00 am - 9:25 am | Anton Bennett (Yale)
"MAP Kinase Phosphatases in Disease Signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Marsha Rosner (University of Chicago)
"RKIP Bridges MAPK and G Protein-Mediated Pathways"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Andres Norambuena (University of Virginia)
"A Rac1-mTOR Pathway Controls Amyloid-Beta Induced, Tau-Dependent, Ectopic Cell Cycle Re-Entry, a Major Cause of Neuron Death in Alzheimer's"
|
10:00 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Jing Liu (Northwestern)
"Suppression of Inflammation by the Transcription Factor Miz1" |
10:15 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | Neal Alto (UT Southwestern Medical Center)
"Bacterial Pathogenesis Through G Protein De-Myristoylation"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Santiago Vernia (University of Massachusetts)
"Metabolic Stress Signaling by JNK"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Natalia Jura (UCSF)
"Regulation of Allosteric Function of HER/ErbB Receptors" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biosynthetic Interactions of Kinases and G Proteins |
| Discussion Leader: Alexandra Newton (UCSD) |
7:30 pm - 7:50 pm | Anabela Srebrow (Universidad de Buenos Aires, Argentina)
"Post-Translation Modifications Influence the Splicing Machinery and Vice Versa"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Xuewu Zhang (UT Southwestern Medical Center)
"How Plexins GAP Rap"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Estela Jacinto (Rutgers University)
"mTORC2 in Cellular Metabolism"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Alexandra Newton (UCSD)
"Functions of Protein Kinase C in Cancer"
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9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | G Protein and Kinase Diversity and Control Mechanisms |
| Discussion Leader: Anne-Claude Gingras (Samuel Lunenfeld Research Institute, University of Toronto) |
9:00 am - 9:25 am | Carmen Dessauer (UT Health Science Center at Houston)
"Sensitization of Neuronal cAMP Signaling by Anchored Adenylyl Cyclase Complexes"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | David Robbins (University of Miami)
"Casein Kinase I As a Therapeutic Target"
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10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Patrick O'Neill (Washington University)
"Subcellular Optogenetics: Asymmetric G Protein Inhibition Induces Polarity" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:10 am | Michael Reese (UT Southwestern Medical Center)
"Virulence Without Catalysis: How Noncatalytic Secreted Effectors Enable Toxoplasma to Foil the Immune System"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Anne-Claude Gingras (Samuel Lunenfeld Research Institute, University of Toronto)
"Proteomics of Dephosphorylation Networks"
|
11:45 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Liam Holt (UC Berkeley)
"Ancestral Resurrection Reveals Mechanisms of Kinase Plasticity" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Kinases and G Proteins in Cancer |
| Discussion Leader: Natalie Ahn (University of Colorado, Boulder) |
7:30 pm - 7:50 pm | Natalie Ahn (University of Colorado, Boulder)
"ERK2 Conformational States and Control of Activity"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jean Wang (UCSD)
"Abl and Apoptosis"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gray Pearson (UT Southwestern Medical Center)
"G Proteins Affecting Cell Identity in Cancer"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Elizabeth Goldsmith (UT Southwestern)
"Chloride Regulates WNK1 by Inhibition of Autophosphorylation" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Detection and Manipulation of Kinase and GPCR Signaling |
| Discussion Leader: Jin Zhang (Johns Hopkins University) |
9:00 am - 9:25 am | Jin Zhang (Johns Hopkins University)
"Compartmentalized Kinase and Phosphatase Signaling in Living Cells"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jurgen Wess (NIH)
"Cell Type-Selective Manipulation of GPCR Signaling Pathways In Vivo"
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10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Rony Seger (Weizmann Institute)
"GqPCR-Induced Apoptosis Is Mediated by an Inactivation of PI3K/AKT via a PP2A Switch" |
10:20 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:10 am | Natalia Riobo (Thomas Jefferson University)
"G Protein-Mediated Regulation of Cardiac Physiology by Smoothened"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Piero Crespo (Universidad de Cantabria, Spain)
"Ras Signals at the Golgi Induce Apoptosis" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Carol Chresterson (Kennesaw State University)
"eNOS Regulation by Rsk" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Pascal Charest (University of Arizona)
"The Small GTPase Rap1 Binds to and Activates TORC2" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structures, Models, Networks |
| Discussion Leader: Melanie Cobb (UT Southwestern Medical Center) |
7:30 pm - 7:50 pm | Walter Kolch (University College, Dublin, Ireland)
"Global and Local Rewiring of Signal Transduction Networks by Oncogenic Mutations"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Stephan Knapp (University of Oxford, England)
"Strategies for Rational Design of Specific Chemical Probes for Protein Kinases"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ron Dror (Stanford University)
"Revealing Activation Mechanisms of GPCRs and G Proteins Through Simulation"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |