Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: G Proteins, Kinases, and Phosphatases - Druggable Targets |
| The third talk in this session, selected from the GRS, is presented in memory of Dr. Alfred G. Gilman. |
| Discussion Leader: Anton Bennett (Yale University, USA) |
7:40 pm - 8:10 pm | Gary Johnson (University of North Carolina School of Medicine, USA) "Chromatin Remodeling and Transcriptome Changes Drive
the Adaptive Response to Targeted Kinase Inhibition" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Tracy Handel (University of California, San Diego, USA) "Structure, Activation Mechanisms and Inhibition
of Chemokine Receptors" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Andre Lazar (University of California, San Francisco, USA) "Regulation of Adenylyl Cyclase by Isoform-Specific Endocytosis" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Spatial and Temporal Dynamics of Cellular Signaling |
| Discussion Leader: Eileen Kennedy (University of Georgia, USA) |
9:00 am - 9:25 am | John Scott (University of Washington, USA) "Guiding Signals Through Anchored Enzyme Complexes" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jin Zhang (University of California, San Diego, USA) "New Fluorescent Biosensors for Visualizing Live-Cell Biochemical Activities at Superresolution" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Thomas Rich (University of South Alabama, USA) "Hyperspectral Imaging Approaches to Measure Localized cAMP Signals" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Bandarigoda Somatilaka (University of Texas Southwestern Medical Center, USA) "Subcellular Trafficking of Adenylyl Cyclases: Primary Cilia and Beyond" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Narasimhan Gautam (Washington University in St. Louis School of Medicine, USA) "Dissecting Cell Behavior with Subcellular Optogenetics" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Kirill Martemyanov (The Scripps Research Institute, USA) "Organization of the G Protein Signaling Cascade of the First Visual Synapse" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lipid Modifications and Signaling |
| Discussion Leader: Maurine Linder (Cornell University, USA) |
7:30 pm - 7:55 pm | Jonathan Backer (Albert Einstein College of Medicine, USA) "The p85/p110beta PI 3-Kinase as a Mediator of G-Protein Signaling" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Ilya Levental (McGovern Medical School, University of Texas Health Science Center at Houston, USA) "Greasing the Way: Protein Lipidation and Lipidomics in Membrane Targeting" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Carol Williams (Medical College of Wisconsin, USA) "Repurposing GPCR-Targeted Drugs to Regulate the
Prenylation and Membrane Localization of Rap, Ras, and Rho Small GTPases in
Cancer: Signaling Mechanisms and Therapeutic Strategies" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Sivaraj Sivaramakrishnan (University of Minnesota Twin Cities, USA) "The Kinase Toolbox: Probing the Regulation of Kinase Function Through Multi-Domain Coordination" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Structural Organization of Cellular Signaling |
| Discussion Leader: Stephen Sprang (University of Montana, USA) |
9:00 am - 9:30 am | Nicholas Tonks (Cold Spring Harbor Laboratory, USA) "Drugging the Undruggable: New Approaches to Exploiting the Protein Tyrosine Phosphatases as Therapeutic Targets" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | John Tesmer (University of Michigan, USA) "Molecular Mechanisms of Effector Regulation by Heterotrimeric G Proteins and Lipids" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Eileen Kennedy (University of Georgia, USA) "Targeting Allosteric Activation of EGFR" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Anne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Canada) "Spatio-Temporal Organization of Signaling Using Quantitative Mass Spectrometry" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Roger Sunahara (University of California, San Diego, USA) "The G Protein- and Agonist-Bound GPCR Conformation: Is This Really the Activated State or Are We Missing Something?" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Matthew Torres (Georgia Institute of Technology, USA) "The
N-Terminal Tails of G Gamma Subunits Are Well-Conserved Targets of Phosphorylation that Regulate G Protein Signaling
in Saccharomyces cerevisiae" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of G Protein Networks |
| Discussion Leader: Kendall Blumer (Washington University in St. Louis, USA) |
7:30 pm - 7:55 pm | John Hepler (Emory University, USA) "RGS14 at the Interface of Hippocampal Signaling and Synaptic Plasticity" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Venetia Zachariou (Icahn School of Medicine at Mount Sinai, USA) "RGS Proteins as Targets for the Treatment of Chronic Pain and Depression" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Mikel Garcia-Marcos (Boston University, USA) "Alternative Signaling Mechanisms via a New Class of G Protein Activators" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Meral Tunc Ozdemir (University of North Carolina at Chapel Hill, USA) "Leucine-Rich Repeat Receptor-Like Kinases (LRR RLKs) Provide Signal Discrimination for Activation of Heterotrimeric G Protein Complex" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Nutrient Sensing and Metabolism |
| Discussion Leader: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Anton Bennett (Yale University, USA) "Signaling Mechanisms in Disease by MAP Kinase
Dephosphorylation" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Kun-Liang Guan (University of California, San Diego, USA) "The Hippo Pathway in Cell Growth and Cancer" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Stefan Offermanns (Max Planck Institute for Heart and Lung Research, Germany) "Regulation of Metabolism and Immune Functions Through Metabolite GPCRs" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Tony Tiganis (Monash University, Australia) "Phosphatases and Obesity" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Melanie Cobb (University of Texas Southwestern Medical Center, USA) "ERKonomics of Lung Cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | New Twists on Cyclic Nucleotide Signaling |
| Discussion Leader: Carmen Dessauer (McGovern Medical School, USA) |
7:30 pm - 7:55 pm | Mark Von Zastrow (University of California, San Francisco, USA) "GPCR Signaling from Internal Membrane Compartments" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Xiaodong Cheng (McGovern Medical School, USA) "EPAC Proteins: Structure, Function and Therapeutics" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA) "cAMP Regulated Signaling in Myogenesis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jochen Buck (Weill Cornell Medical College, USA) "Soluble Adenylyl Cyclase Is Essential for Proper Lysosomal Acidification" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling Networks in Times of Stress |
| Discussion Leader: Melanie Cobb (University of Texas Southwestern Medical Center, USA) |
9:00 am - 9:25 am | Silvio Gutkind (University of California, San Diego, USA) "Novel G-Protein Regulated Signaling Networks in Stem Cell Fate Decisions and Cancer" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Barry Willardson (Brigham Young University, USA) "Chaperone-Mediated Assembly of the mTORC1 Complex" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Natalia Riobo (University of Leeds, United Kingdom) "Non-Canonical Hedgehog Signalling Regulates Autophagy" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Henrik Dohlman (University of North Carolina at Chapel Hill, USA) "Metabolomics Analysis of Stress-Dependent Second Messengers" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Gregory Tall (University of Michigan, USA) "Receptor Tyrosine Kinase Pathway Tuning of Heterotrimeric G Protein
Signaling by G Protein Abundance Modulation" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Yonghao Yu (University of Texas Southwestern Medical Center, USA) "Navigating Downstream of mTOR: A Quantitative Proteomic Approach" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling Networks in Cardiac Stress and Disease |
| Discussion Leader: Natalia Riobo (University of Leeds, United Kingdom) |
7:30 pm - 7:55 pm | Maria Kontaridis (Harvard Medical School, USA) "Role of SHP2 Phosphatase in Cardiac Development and Disease" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alan Smrcka (University of Rochester School of Medicine, USA) "Intracellular Phospholipase C Signaling Networks in Cardiac Function and Disease" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Joan Heller Brown (University of California, San Diego, USA) "GPCR and RhoA-Mediated Transcriptional Regulation in Cell Proliferation and Survival" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |