Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Hub of Signal Integration
Discussion Leader: Anton Bennett (Yale University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
Melanie Cobb (University of Texas Southwestern Medical Center, USA)
"Environmental ERKonomics"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism: Ying and Yang of Metabolic Signaling Networks
Discussion Leader: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA)
9:00 am - 9:30 am
Sorin Tunaru (Max Planck Institute for Heart and Lung Research, Germany)
"Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA)
"Kinase-Mediated Regulation of Muscle Glucose Disposal"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Lasse Bak (University of Copenhagen, Denmark)
"AMP Kinase-Mediated Selective Activation of Astrocyte Glycolysis via Phosphorylation of PFKFB3 as a Novel Therapeutic Approach in Alzheimer's Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Matthew Spite (Harvard Medical School / Brigham and Women's Hospital, USA)
"Inflammation-Resolving Lipid Mediators and Their Receptors"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ahmed Lawan (Yale University, USA)
"Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Nicole Tensmeyer (Brigham Young University, USA)
"Chaperone Mediated Assembly of mTOR Complexes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Ranga Rajan (University of North Carolina at Chapel Hill, USA)
"An Alternative G Protein Signaling Pathway Leads to Autophagy in Saccharomyces cerevisiae "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroscience: Wiring the Neuron by Phosphorylation and G-Proteins
Discussion Leader: Alan Smrcka (University of Michigan, USA)
7:30 pm - 8:00 pm
Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Loss of Opioid and Gi-Dependent Inhibition of Adenylyl Cyclase After Spinal Cord Injury"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Linda Van Aelst (Cold Spring Harbor Laboratory, USA)
"Rho Regulator-Mediated Signaling in Inter-Neuron Development and Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Smita Yadav (University of Washington, USA)
"Unmasking Aberrant Phosphorylation Networks in 16p11.2 CNV Associated Autism"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Lipids Linking Signaling
Discussion Leader: Kun-Liang Guan (University of California, San Diego, USA)
9:00 am - 9:30 am
Jonathan Backer (Albert Einstein College of Medicine, USA)
"PI3Kbeta Signaling in Invasion and Metastasis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Mathew Tantama (Purdue University, USA)
"Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics"
9:50 am - 9:55 am
Discussion
9:55 am - 10:25 am
Lloyd Trotman (Cold Spring Harbor Laboratory, USA)
"PTEN and the Digital Signaling Hub"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Selected from Poster Abstracts: Alexey Bondar (Augusta University, USA)
"Gs Protein Subunits Avoid, but Are Not Excluded from, Clathrin-Coated Pits"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Selected from Poster Abstracts: Shelley Hooks (University of Georgia, USA)
"RGS10 Regulates COX-2 and TNFalpha Through G Protein Independent Mechanisms"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Aashish Manglik (University of California, San Francisco, USA)
"Structural Basis of Opioid Receptor Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Yingrong Xu (Pfizer, USA)
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiovascular System and Vascular Networks
Discussion Leader: Gregory Tall (University of Michigan, USA)
7:30 pm - 8:00 pm
Alan Smrcka (University of Michigan, USA)
"Subcellular Control of Phospholipase Cepsilon Signaling in Cardiac Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Jaesung Yi (Yale School of Medicine, USA)
"PZR Tyrosyl Phosphorylation Is Associated with Hypertrophic Cardiac Gene Expression in Shp2 Associated NSML Model Mice"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Thomas Rich (University of South Alabama, USA)
"High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Nariman Balenga (University of Maryland School of Medicine, USA)
"G-Protein-Dependent and -Independent Signaling of Orphan Adhesion GPCR, GPR64"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Visualization and Model Systems in Signaling
Discussion Leader: Carmen Dessauer (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
9:00 am - 9:30 am
Jin Zhang (University of California, San Diego, USA)
"Spatial Compartmentalization of Second Messengers and Kinase Complexes in Living Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Henrik Dohlman (University of North Carolina at Chapel Hill, USA)
"G Protein-Mediated Autophagy in Yeast"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Pascale Charest (University of Arizona, USA)
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Selected from Poster Abstracts: Chuan-Hsiang Huang (Johns Hopkins University, USA)
"Integrating Chemical and Mechanical Signals Through Dynamic Coupling Between Protrusions and ERK Activation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Roger Sunahara (University of California, San Diego, USA)
"The Allostery in G Protein Coupling: From G Proteins to Small Molecules to Cations"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Ajith Karunarathne (The Univerisity of Toledo, USA)
"Identity Matters: Ggamma-Type Dictates Efficacy of Gbetagamma Signaling and Cellular Decisions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Angeline Lyon (Purdue University, USA)
"Conformational Regulation of Phospholipase C Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cyclic Nucleotides and GPCR Signaling
Discussion Leader: Henrik Dohlman (University of North Carolina at Chapel Hill, USA)
7:30 pm - 8:00 pm
Roshanak Irannejad (University of California, San Francisco, USA)
"Toward a Spatiotemporal Logic of Cellular GPCR Signaling by cAMP and PKA"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Shilpa Choudhury (Georgia Institute of Technology, USA)
"Negative Feedback Phosphorylation of G Gamma Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Gregory Tall (University of Michigan, USA)
"MAPK Pathway Regulation of Heterotrimeric G Protein Signaling Tone"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Fadia Kamal (Penn State College of Medicine, USA)
"Therapeutic Targeting of GPCR Gbetagamma-GRK2 Signaling in Osteoarthritis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Nexus of Phosphorylation and G-Protein Signaling
Discussion Leader: Natalie Ahn (University of Colorado Boulder, USA)
9:00 am - 9:30 am
Kun-Liang Guan (University of California, San Diego, USA)
"Regulation of the Hippo Pathway"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Nicholas Tonks (Cold Spring Harbor Laboratory, USA)
"New Approaches to Exploiting PTP1B as a Therapeutic Target"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Mary Kay Pflum (Wayne State University, USA)
"Chemical Approaches to Identifying Kinase and Phosphatase Substrates"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Selected from Poster Abstracts: Yonghao Yu (University of Texas Southwestern Medical Center, USA)
"Non-Cell Autonomous Regulation of mTORC1-Dependent Feedback Mechanisms"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
Venetia Zachariou (Icahn School of Medicine at Mount Sinai, USA)
"Targeting RGSz1 Pathways for the Treatment of Chronic Pain"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Anibal Garza Carbajal (University of Texas Health Science Center at Houston, USA)
"Mechanisms Inducing Opioid Resistance After Spinal Cord Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Zheng Fu (University of Virginia, USA)
"ICK Signaling in Ciliopathy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Biology and Protein Phosphorylation
Discussion Leader: Jin Zhang (University of California, San Diego, USA)
7:30 pm - 8:00 pm
Natalie Ahn (University of Colorado Boulder, USA)
"Oncogenic B-Raf Signaling in Melanoma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
J. Silvio Gutkind (University of California, San Diego, USA)
"GPCR Signaling and Cancer Immune Therapies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Selected from Poster Abstracts: Ankita Jaykumar (University of Texas Southwestern Medical Center, USA)
"Biological Cross-Talk Between WNK1 and TGF-Beta Signaling Pathway"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Diwakar Pattabiraman (Norris Cotton Cancer Center, Dartmouth College, USA)
"Unraveling a Role for PKA in Mammary Development and Tumor Progression"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure