Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Regulation of Protein Kinase Signaling
Discussion Leader: Anton Bennett (Yale University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
Alexandra Newton (UCSD, United States)
"Protein Kinase C Unbalanced: Loss-of-Function vs Gain-of-Function Mutations in Disease"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Marc Wein (Massachusetts General Hospital, United States)
"Salt Inducible Kinases Control the Skeletal and Renal Actions of Parathyroid Hormone"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Robert Screaton (University of Toronto, Canada)
"Regeneration and the Post-Mitotic state: Can We Stop G0?"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Proximal Kinase and G Protein Signaling
Discussion Leader: Alan Smrcka (University of Michigan, United States)
9:00 am - 9:20 am
Heidi Hamm (Vanderbilt University, United States)
"Regulation of Exocytosis by Inhibitory GPCRs and Gβγ Subunits"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Alan Jones (University of North Carolina at Chapel Hill, United States)
"Biased Signaling: Distinct Ligand-Directed Trafficking of Plasma Membrane Signalosomes Using a Common RGS/G-Protein Core"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nevin Lambert (Medical College of Georgia, United States)
"Unconventional Interactions Between GPCRs and G Proteins"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ku-Lung Hsu (University of Virginia, United States)
"Protein and Lipid Discovery on a Global Scale"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Nam Chu (Ohio State University, United States)
"Mechanisms of Protein Kinase Akt Activation Revealed Using Protein Semisynthesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Lalima K Madan (Medical University of South Carolina , United States)
"Dynamics-Based Explanations of Allostery in Protein Tyrosine Phosphatases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Carol Williams (Medical College of Wisconsin, United States) and Angeline Lyon (Purdue University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cyclic Nucleotide Regulated Signaling
Discussion Leader: Carmen Dessauer (University of Texas Health Science Center at Houston, United States)
7:30 pm - 7:50 pm
Susan Taylor (University of California, San Diego, United States)
"PKA Signaling: New Frontiers from the Dark Kinome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Xiaodong Cheng (University of Texas Health Science Center at Houston, United States)
"EPAC1 Stressed Out Wrestling with SUMO"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Lonny Levin (Weill Cornell Medicine, United States)
"Bicarbonate-Regulated Soluble Adenylyl Cyclase as Therapeutic Target"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Thomas Rich (University of South Alabama, United States)
"High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Justin English (University of Utah, Department of Biochemistry, United States)
"A High-Throughput SynBio System to Profile GPCR Signaling in Mammalian Cells"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
G Protein and Kinase Signaling in Physiological Control
Discussion Leader: Henrik Dohlman (University of North Carolina, United States)
9:00 am - 9:20 am
Carmen Dessauer (University of Texas Health Science Center at Houston, United States)
"Anchored Constraints of Adenylyl Cyclase Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Gregory Tall (University of Michigan, United States)
"Adhesion GPCR Activation Mechanism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Venetia Zachariou (Icahn School of Medicine at Mount Sinai, United States)
"RGS4 Maintains Chronic Pain and Promotes Antidepressant Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 10:40 am
Nicholas Harbin (Emory University, United States)
"Regulator of G-Protein Signaling 14 (RGS14) Protects Against Behavioral And Pathological Responses Due To Kainic Acid-Induced Status Epilepticus"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Group Photo / Coffee Break
11:15 am - 11:35 am
Kirill Martemyanov (The Scripps Research Institute, United States)
"Beyond the Ligand: Emerging World of mGluR Control by Extracellular Interactions"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Jiung Jung (UT Southwestern Medical Center, United States)
"A Few Good WNKs"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Harrison McNabb (Purdue University, United States)
"N-Terminal Targeting of RGS2 for FBXO44-Mediated Proteasomal Degradation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Physiological and Chemical Regulation of G Protein Activity
Discussion Leader: Kirill Martemyanov (The Scripps Research Institute, United States)
7:30 pm - 7:50 pm
Roger Sunahara (University of California, San Diego, United States)
"The Open Confirmation of Heterotrimeric G Proteins: Implications to Signaling and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Evi Kostenis (University of Bonn, Germany)
"FR900359: With a Splendid Gift from Nature to Fundamental Insights into GPCR and G Protein Biology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mikel Garcia-Marcos (Boston University, United States)
"GPCR-Independent G Protein Signaling"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Anna Pepanian (University of Bonn, Germany)
"Modulation of Gai1/s Proteins with Molecules Targeting the Guanine Nucleotide Binding Pocket"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Natalie Hewitt (University of North Carolina at Chapel Hill, United States)
"Non-Catalytic Functions of the Catalytic Glutamine in G Proteins"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
GPCR-Activated Signaling in Control of Cell Proliferation and Cancer
Discussion Leader: John Scott (University of Washington School of Medicine, United States)
9:00 am - 9:20 am
J. Silvio Gutkind (University of California, San Diego, United States)
"G Proteins and GPCRs in Cancer: Exploiting Signaling Vulnerabilities for Multimodal Therapies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Michael Onken (Washington University in St. Louis, United States)
"Pharmacological Targeting of Oncogenic G Proteins in Ocular Melanoma"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
James Hoy (Laboratory of Cellular and Molecular Biology, National Cancer Institute, United States)
"Protein Kinase A-Inhibitor Alpha Enhances Prostate Cancer Progression and Metastasis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Michelle Kimple (University of Wisconsin-Madison, United States)
"G Protein-Mediated Signaling Switches Controlling Beta-Cell Compensation in Type 2 Diabetes"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Antonio Amelio (University of North Carolina at Chapel Hill, United States)
"Oncogenic CREB Coactivator Signaling in HPV(+) Head and Neck Cancer"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Antonio Soares (The University of Texas Health Science Center at Houston, United States)
"cAMP Signaling and CREB-Activated Transcription Coordinate Muscle Satellite Cell Proliferation During Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling Beyond the Plasma Membrane
Discussion Leader: Roshanak Irannejad (University of California, San Francisco, United States)
7:30 pm - 7:50 pm
Carol Williams (Medical College of Wisconsin, United States)
"Splice-Switching Oligonucleotides to SmgGDS Suppress the Prenylation of G Proteins, Large and Small"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jeffrey Frost (University of Texas Health Science Center at Houston, United States)
"Localization-Dependent RhoA Signaling in Breast Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Smita Yadav (University of Washington, United States)
"Tale of Two TAO Kinase Tails"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Emily Blythe (University of California, San Francisco, United States)
"Biphasic cAMP Signaling Through VIPR1 is Sculpted by both Constitutive Receptor Internalization and ß-Arrestin Recruitment"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Blair Willette (Duke University, United States)
"Endosome Positioning Coordinates Spatially Selective GPCR Signaling"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Integration of Phosphorylation and G Protein Mediated Signaling
Discussion Leader: Benita Sjogren (Purdue University, United States)
9:00 am - 9:20 am
Anton Bennett (Yale University, United States)
"Novel Mechanisms of MAP Kinase Phosphatase Regulation: Implications to Therapeutics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
John Scott (University of Washington School of Medicine, United States)
"Exploring and Exploiting the Spatial Constraints of cAMP Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yonghao Yu (Columbia University Irving Medical Center, United States)
"Navigating Downstream of mTOR: A Quantitative Proteomic Approach"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jurgen Wess (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, United States)
"Use of DREADD Technology to Study G Protein-Mediated Signaling In Vivo"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Roshanak Irannejad (University of California, San Francisco, United States)
"Regulation of GPCR Signaling by Transporters"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yonghoon Kwon (University of California, San Diego, United States)
"Non-canonical ß-adrenergic Activation of ERK at Endosomes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Neil Grimsey (University of Georgia, United States)
"Tracking and Inhibiting Atypical Vascular Inflammation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Structural Aspects of G Protein Signaling
Discussion Leader: Roger Sunahara (University of California, San Diego, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
John Tesmer (Purdue University, United States)
"Exploring Effector Enzyme Mechanism Through the Lens of Structural Biology"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Stephen Sprang (University of Montana, United States)
"How Ric-8 Wrangles Galpha"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Angeline Lyon (Purdue University, United States)
"Atomic Structure and G Protein Regulation of PLCs"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure