SATURDAY |
1:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 4:30 pm | Keynote Lecture |
3:45 pm - 4:15 pm | T. Kendall Harden (University of North Carolina at Chapel Hill, USA)
"Mechanisms of the Gq/Phospholipase C-β Signaling Complex"
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4:15 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel GPCR Signaling Mechanisms |
| Discussion Leaders: Carmen W. Dessauer (University of Texas-Houston Medical School, USA) and Elena Borroni (Instituto Clinico Humanitas, University of Milan, Italy) |
7:30 pm - 7:50 pm | Jasmin Leschner (Ludwig-Maximilians-Universität, Germany)
"Role of β-arrestin 1 and 2 in bradykinin B2 receptor regulation and signaling"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jillian Hurst (University of North Carolina at Chapel Hill, USA)
"Dynamic ubiquitination of the MAP2K Ste7 determines the strength and specificity of signaling in the yeast pheromone pathway"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Stephanie Dusaban (University of California, San Diego, USA)
"The role of phospholipase c-epsilon in COX-2 expression and inflammation"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Divya Prasanna Kumar (Virginia Commonwealth University, USA)
"Activation of transmembrane bile acid receptor TGR5 stimulates both insulin gene transcription and insulin release in pancreatic β Cells"
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9:20 pm - 9:30 pm | Discussion |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Advances in Canonical Kinase and G Protein Signaling |
| Discussion Leaders: Jin Zhang (The Johns Hopkins University, USA) and Kristoff Homan (University of Michigan, USA) |
9:00 am - 9:20 am | Jesse Zalatan (University of California, San Francisco, USA)
"Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Rebecca Plimpton (Brigham Young University, USA)
"Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a molecular mechanism for G protein β subunit folding and βγ dimer assembly"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Yong Li (University of Texas-Houston Medical School, USA)
"The A-kinase anchoring protein Yotiao facilitates complex formation between type 9 adenylyl and the IKs potassium channel in heart"
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10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Ekaterina Posokhova (The Scripps Research Institute, USA)
"RGS6 regulates heart rate variability in isolated hearts" |
10:50 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Translational Pharmacology |
| Discussion Leaders: Alan V. Smrcka (University of Rochester, NY, USA) and Jiaxiao Shen (University of Cambridge, United Kingdom) |
1:30 pm - 1:50 pm | Michael Lee (Massachusetts Institute of Technology, USA)
"Sequential exposure to anti-cancer drugs enhances cell death by dynamic re-wiring of apoptotic signaling networks"
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1:50 pm - 2:00 pm | Discussion |
2:00 pm - 2:20 pm | Susann Björk (University of Turku, Finland)
"α2-adrenoceptor elicited vascular smooth muscle cell contraction - discerning the intracellular pathways involved"
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2:20 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |