Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Octopamine Receptors Coordinate Response to Chronic Exercise in Drosophila
Discussion Leaders: Anibal Garza Carbajal (University of Texas Health Science Center at Houston, United States) and Tom Rossetti (Weill Cornell Medicine, United States)
3:45 pm - 4:00 pm
Opening Remarks
4:00 pm - 4:25 pm
Robert Wessells (Wayne State University School of Medicine, United States)
"Octopamine Receptors Coordinate Response to Chronic Exercise in Drosophila"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Signal Transduction in Cellular and Organismal Regulation
Discussion Leaders: Dipak Patil (Scripps Research, United States) and Isaac Fisher (Purdue University, United States)
7:30 pm - 7:45 pm
Gissell Sanchez (University of Michigan, United States)
"Phospholipase C-ß(PLCß) is a Coincidence Detector for Gq and Gi Signaling that Modulates - Opioid Receptor-Dependent Antinociception"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Anibal Garza Carbajal (University of Texas Health Science Center at Houston, United States)
"Cellular Mechanisms Altering Opioid Effectiveness in Sensory Neurons after Spinal Cord Injury"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Randal Serafini (Icahn School of Medicine at Mount Sinai, United States)
"Disruption of RGS4 Action in the Dorsal Root Ganglia Prevents the Development of Chronic Neuropathic Pain States"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Harrison McNabb (Purdue University, United States)
"N-Terminal Targeting of RGS2 for FBXO44-Mediated Proteasomal Degradation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Natasha Puri (University of California San Francisco, United States)
"Organic Cation Transporter 2 Regulates D1 Dopamine Receptor Signaling at the Golgi Apparatus"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Niamh Sayers (Imperial College London, United Kingdom)
"Follicle-Stimulating Hormone Induces Lipid Droplets via Gai and Beta Arrestins in an Endometrial"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Structural Elucidation of G-Protein Signaling Components
Discussion Leaders: Antonio Soares (The University of Texas Health Science Center at Houston, United States) and Gissell Sanchez (University of Michigan, United States)
9:00 am - 9:25 am
Evi Kostenis (University of Bonn, Germany)
"G Protein-Coupled Versus Arrestin-Coupled Receptors: Exploiting Mechanistic Differences for Therapeutic Benefit"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Dipak Patil (Scripps Research, United States)
"Visualizing an Orphan Receptor GPR158 and it Complex with Neuronal Regulator RGS7-Gß5 via CryoEM"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Blair Willette (Duke University, United States)
"Endosome Positioning Coordinates Spatially Selective GPCR Signaling"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Tyler Lefevre (University of Michigan, United States)
"Novel Effector Specificity of the Gai G Protein Subfamily is Determined by its Helical Domain"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Isaac Fisher (Purdue University, United States)
"Single Particle Cryo-EM Reconstruction of an Activated Gß-PLCß Complex"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Novel Methods to Study G-Protein Signaling Mechanisms
Discussion Leaders: Anibal Garza Carbajal (University of Texas Health Science Center at Houston, United States) and Tom Rossetti (Weill Cornell Medicine, United States)
1:30 pm - 1:45 pm
Matthew Klauer (Duke University, United States)
"Multiomics Analysis Pipeline to Interrogate Translational Regulation to GPCR Signaling and its Spatial Bias"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Judith Alenfelder (University of Bonn, Institute of Pharmaceutical Biology, Germany)
"Chemogenetic G Protein-Ligand Pairs for Causal Investigation of Cellular Biology in Drosophila Melanogaster"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
Panel Discussion
Career Development Session
Evi Kostenis (University of Bonn, Germany)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
