Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Spatial Regulation of G-Protein Signaling
Discussion Leader: Priyanka Naik (Purdue University, United States)
3:45 pm - 3:55 pm
Nicole Fisher (University of California, San Francisco, United States)
"Probing the Subcellular Dynamics of Gi/o Activation with an Active-State Biosensor"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Federica Liccardo (University of California, San Francisco, United States)
"Selective Activation of Intracellular ß1AR using Spatially Restricted Antagonist"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Nisha Patel (University of Minnesota, Twin Cities, United States)
"Myosin VI Mediates Spatiotemporal Trafficking and Signaling of GPCRs"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biophysics and Pharmacology of Signaling Complexes
Discussion Leader: Anibal Garza Carbajal (University of Texas Health Science Center at Houston, United States)
7:30 pm - 7:45 pm
Sukrit Singh (Memorial Sloan Kettering Cancer Center, United States)
"Parsing Kinase Drug Resistance Mechanisms using Distributed Computing"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Sumit Bandekar (University of Chicago, United States)
"Structural Basis for Regulation of CELSR1 by a Compact Module in its Extracellular Region"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Yasmin Aydin (Institute of Biochemistry, Leipzig University, Germany)
"Transducer Coupling to G Protein-Coupled Receptors is Critically Regulated by Intracellular Loop 3"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Lauren Anderson (University of California, Davis, United States)
"Accessories Are a GEF’s Best Friend"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Yueyi Chen (Purdue University, United States)
"Structural Insights into a New Class of Highly Potent and Selective Inhibitors for GRK5"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Chrystine Gallegos (University of Texas Health Science Center at Houston, United States)
"Effects of Satellite Glial Cell Signaling and Stimulation on Isolated DRG Nociceptors"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Subcellular Compartmentalization of Signaling
Discussion Leader: Sergi Bravo (University of Bonn, Germany)
9:00 am - 9:45 am
Carmen Dessauer (McGovern Medical School, University of Texas Health Houston, United States)
"Potentiating Opioid Inhibition of cAMP Signaling in Neuropathic Pain after Spinal Cord Injury"
9:45 am - 10:00 am
Discussion
10:00 am - 10:45 am
Roshanak Irannejad (University of California, San Francisco, United States)
"Fine-Tuning Subcellular GPCR Signaling by Transporters"
10:45 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Insights into Gq Signaling
Discussion Leader: Nathalie Momplaisir (University of Michigan, United States)
1:30 pm - 1:45 pm
Joseph Loomis (University of Michigan, United States)
"Identifying Potentially Novel Gaq Interaction Partners"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Carole Daly (Queen's University Belfast, United Kingdom)
"The Conundrum Linked to Endosomal Gq Signalling: Toward New Answers"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Lars Jürgenliemke (University of Bonn, Germany)
"Glue-Tiful Inhibitors: Cyclic Depsipeptides Enhance Proximity Within the Subunits of Heterotrimeric Gq/11 Proteins"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
