SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | OVERVIEW OF PHOTORECEPTOR STRUCTURE AND ACTIVATION MECHANISMS |
| Discussion leader: John Spudich (University of Texas, Houston) |
7:30 pm - 7:40 pm | Welcome from the Chair & Vice-Chair |
7:40 pm - 7:50 pm | Introduction |
7:50 pm - 8:10 pm | John Spudich (University of Texas, Houston)
"The multitalented microbial sensory rhodopsins" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Kevin Ridge (University of Texas, Houston)
"Conformational changes in the alpha-subunit of transducin accompanying rhodopsin-catalyzed guanine nucleotide exchange" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Ulrich Genick (Brandeis University)
"Conformational micro-heterogeneity separates function from non-functional states of PYP" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Klaas Hellingwerf (Swammerdam Institute, The Netherlands)
"On the biological function of YtvA from B. subtilis" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS I: PHOTOTROPINS |
| Discussion Leader: Keith Moffat (University of Chicago) |
9:00 am - 9:20 am | Winslow Briggs (Carnegie Institution, Stanford)
"Phototropins: Why do they have two LOV domains?" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Kevin Gardner (University of Texas Southwestern, Dallas)
"NMR structural studies of PAS Domain Receptors" |
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Robert Bittl (Freie Univeristy Berlin, Germany)
"On the reaction mechanism of LOV adduct formation" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 12:30 pm | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION I: PHOTOTROPINS |
| Discussion Leader: Winslow Briggs (Carnegie Institute of Washington, Stanford University) |
10:30 am - 10:45 am | Masamitsu Wada (National Institute of Basic Biology, Okazaki Japan)
"How to move chloroplasts using actin filaments" |
10:45 am - 10:50 am | Discussion |
10:50 am - 11:05 am | John Christie (University of Glasgow, United Kingdom)
"Domain swapping to assess LOV-domain function in regulating phot1 kinase activity" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Ken-Ichiro Shimazaki (Kyushu University, Japan)
"Type 1 protein phosphatase mediates the signaling between phototropin and the plasma membrane H+-ATPase in guard cells" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | S. Tokutomi (Univ. of Osaka Prefect. University, Japan)
"Distinct roles of LOV domains in blue light photoreceptors" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Trevor Swartz (University of California, Santa Cruz)
"Light-activated LOV domain histidine kinases" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Aba Losi (University of Parma, Italy)
"Conformational analysis of the blue-light sensitive bacterial protein YtvA in solution" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Klaus Schulten (University of Illinois, Urbana)
"When light falls in LOV: Molecular dynamics of the LOV-domain activation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:00 pm | Poster Session |
5:30 pm - 7:30 pm | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS II: BACTERIAL AND LOWER EUKARYOTE PHOTORECEPTORS |
| Discussion Leader: Klaas Hellingwerf (Swammerdam Inst.of Life Sciences, The Netherlands) |
5:30 pm - 5:50 pm | Keith Moffat (Univ. of Chicago)
"Signal transduction at the atomic level in photoreceptors" |
5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:10 pm | Ilme Schlichting (MPI Dortmund, Germany)
"How to BLUF: Structural suggestions" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm- 6:30 pm | John Kennis (Vrije Universiteit, Amsterdam)
"The Mechanism of Activation of BLUF domains" |
6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:50 pm | Joachim Heberle (University of Bielefeld, Germany)
"FTIR studies on BLUF receptors" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:05 pm | Jason Key (Vrije Universiteit Amsterdam)
"On the biological function of YcgF from E. coli" |
7:05 pm - 7:10 pm | Discusson
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7:10 pm - 7:25 pm | Janos Lanyi (University of California, Irvine)
"Xanthorhodopsin, a novel retinal protein with carotenoid antenna" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS III: STRUCTURE OF RHODOPSINS AND MICROBIAL RHODOPSINS |
| Discussion Leader: Janos Lanyi (University of California, Irvine) |
9:00 am - 9:20 am | G. Schertler (MRC Cambridge, United Kingdom)
"Structure of rhodopsin and implications for GPCRs: Microcrystallography and microspectroscopy developments and trends" |
9:00 am - 9:25 am | Discussion |
9:25 am - 9:35 am | Georg Bueldt (Research Center Juelich, Germany)
"Development of the signal in sensory rhodopsin and its transfer to the cognate transducer" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Hartmut (Hudel) Luecke (UC Irvine, CA)
"Structures but little function for a pair of proteins: a microbial photoreceptor and its transducer" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 12:30 pm | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS III: ACTIVATION OF RHODOPSINS AND MICROBIAL RHODOPSINS |
| Discussion Leader: Hartmut (Hudel) Luecke (University of California, Irvine) |
10:30 am - 10:40 am | Phil Kukura (UC Berkeley, CA)
"Observation of the rhodopsin photoisomerization with femtosecond Stimulated Raman Spectroscopy" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Michael Brown (University of Arizona)
"Chromophore dynamics in the binding site of rhodopsin from solid state NMR" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Michael Pitman (IBM Research Labs)
"Molecular dynamics simulations of rhodopsin in the 1000-nanosecond time window" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35am | Ulrike Alexiev (Freie Universitat Berlin)
"Two-dimensional visualization of surface dynamics and conformational changes in active rhodopsin" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Jonathan Ruprecht (Medical Research Council, United Kingdom)
"The structure of rhodopsin's meta-I state" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Thomas Sakmar (Rockefeller Univ. New York)
"Rhodopsin Dynamics in Bilayers: Ligand Channeling and Receptor Mixing" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ned Van Eps (University of California, Los Angeles)
"A Site-Directed Spin Labeling Study of the Rhodopsin/Transducin Complex: Structure and Dynamics Changes within Ga During Activation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:00 pm | Poster Session |
5:30 pm - 6:30 pm | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS IV: PHYTOCHROMES |
| Discussion Leader: Clark Lagarias (University of California, Davis) |
5:30 pm - 5:50 pm | Katrina Forest (University of Wisconsin, Madison)
"Structure of the chromophore-binding domain of phytochrome" |
5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:10 pm | Andre Vermeglio (CEA, France)
"Diversity and the roles of bacteriophytochromes in the photosynthetic bacterium Rhodopseudomonas" |
6:10 pm - 6:25 pm | Jasper van Thor (University of Oxford, United Kindom)
"IR and NMR spectroscopy of cyanobacterial phytochrome Cph1" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 7:30 pm | RECEPTOR STRUCTURE AND ACTIVATION MECHANISMS V: CRYPTOCHROMES |
| Discussion Leader: Chentao Lin (University of California, Los Angeles) |
6:30 pm - 6:50 pm | Margaret Ahmad (Universite Pierre and Marie Curie, France)
"Cryptochrome Photoreceptor Mechanisms of Action" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:10 pm | Lars-Oliver Essen (Marburg University, Germany) |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | M. Terazima (Kyoto University, Japan)
"Time-resolved detection of conformational change of cryptochrome" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 9:20 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:20 am - 12:30 pm | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION I: RHODOPSINS AND MICROBIAL RHODOPSINS |
| Discussion leader: Martin Engelhard (MPI, Dortmund, Germany) |
9:20 am - 9:35 am | David Farrens (Oregon Health and Science University) |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Ernst Bamberg (MPI Biophysics, Frankfurt)
"Channelrhodopsins: A new class of ion channels functional description and applications" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
| Discussion Leader: Gebhard Schertler (MRC, Cambridge, United Kingdom) |
10:30 am - 10:50 am | Dieter Oesterhelt (MPI Martinsried)
"Signal transduction in archaea" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:15 am | Hideki Kandori (Nagoya Institute of Technology, Japan )
"FTIR study of archaeal rhodopsins" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Martin Engelhard (MPI Dortmund, Germany)
"The sensory rhodopsin II-transducer complex: HAMP domain and signal transfer" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Peter Hegemann (Humboldt-University Berlin, Germany)
"Kinetics of channelrhodopsin-1 and acetabulariarhodopsin derived from electrical studies" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Leonid Brown (University of Guelph)
"Cytoplasmic shuffling of protons in anabaena sensory rhodopsin: Implications for a signaling mechanism" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | N. Kamo (Hokkaido University, Japan)
"Binding of archaeal rhodopsins with N. pharaonis halobacterial transducer II" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:00 pm | Poster Session |
5:30 pm - 7:30 pm | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION III: PHYTOCHROMES |
| Discussion leader: Eberhard Schaefer (University of Freiburg, Germany) |
5:30 pm - 5:45 pm | Pill Soon Song (Cheju National University)
"Bathochromic mutant phytochromes A, and their shade tolerance roles" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Meng Chen (The Salk Institute)
"Phytochrome-dependent nuclear architectural remodeling" |
6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Eberhard Schaefer (University of Freiburg)
"Intracellular localization and signal transduction of phyB" |
6:30 pm - 6:35 pm | Discussion |
6:35 pm - 6:50 pm | Tilman Lamparter (Freie Universitat, Berlin)
"Phytochromes of Agrobacterium tumefaciens: chromophore assembly, photoconversion, modulation of kinase activity and approaches to biological functions" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:10 pm | Christian Fankhauser (University of Lausanne, Switzerland)
"Early nuclear events during phytochrome signaling in Arabidopsis" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Sergei Balashov (University of California, Irvine)
"Interaction of salinixanthin with the retinal chromophore in xanthorhodopsin" |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:30 am | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION IV: RECENT DEVELOPMENTS IN OTHER PHOTORECEPTORS |
| Discussion Leader: Pill Soon Song (Cheju National University) |
9:00 am - 9:15 am | Devaki Bhaya (Carnegie Institution of Washington, Stanford)
"Phototaxis and signal transduction in cyanobacteria" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Luis M. Corrochano (Universidad Sevilla, Spain)
"Blue-light photoreceptors in Phycomyces" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Timo Luedtke (Friedrich-Alexander Universitat Erlangen-Numberg, Germany)
"Phototaxis photoreceptor in Euglena gracilis" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:40 am | Giovanni Checcucci (CNR, Italy)
"Molecular structure and dynamics of Blepharisma japonicum photoreceptor" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:40 am | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION IV: CRYPTOCHROMES |
| Discussion Leader: Margaret Ahmad (Universite Pierre and Marie Curie, France) |
10:45 am - 11:00 am | Tilman Kottke (Juelich, Germany)
"Insight into blue-light-induced changes in arabidopsis cryptochrome" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Wolfgang Wiltschko (University of Frankfurt)
"Cryptochrome as a possible transducer molecule for magnetoreception in birds" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Pradeep Ramachandran (Oxford University)
"Structural changes in Arabidopsis Cryptochrome 1 upon Blue light illumination" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:30 pm | MECHANISMS OF SIGNAL RELAY AND SIGNAL TRANSDUCTION V: THE PYP PHOTORECEPTORS |
| Discussion Leader: Michael Cusanovich (University of Arizona) |
11:40 am - 11:55 am | Maarten Heyn (Freie University, Berlin)
"Formation of the signaling state of PYP" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Luuk van Wilderen (Vrije Universiteit Amsterdam)
"On the initial events in the photocycle of PYP" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Michael van der Horst (Vrije Universiteit Amsterdam)
"The family of the xanthopsins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | BIOLOGICAL CLOCKS AND CIRCADIAN RHYTHMS |
| Discussion Leader: Jennifer Loros (Dartmouth University) |
5:30 pm - 5:50 pm | Samer Hattar (Johns Hopkins University)
"Role of mammalian retinal photoreceptors in non-image-forming visual functions" |
5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:15 pm | Satchin Panda (The Salk Institute)
"Melanopsin phototransduction pathway" |
6:15 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Jay Dunlap (Dartmouth University)
"Translation and modification for light and clock-specific forms of WC-2" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Susan Golden (Texas A&M University)
"Integration of environmental sensing pathways with the oscillator of the cyanobacterial circadian clock" |
7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | General Discussion |
7:25 pm - 7:30 pm | Concluding Remarks: Chair Roberto Bogomolni (University of California, Santa Cruz) and Vice-Chair Klaas Hellingwerf (Swammerdam Institute of Life Sciences, The Netherlands) |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |