SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:50 pm | Opening Remarks: Kevin Gardner (UT Southwestern Medical Center) |
7:40 pm - 9:30 pm | VISUAL RHODOPSINS: MODELS FOR GPCR SIGNALING |
| Discussion Leader: Oliver Ernst (Charité - Universitätsmedizin Berlin) |
7:50 pm - 8:20 pm | Oliver Ernst (Charité - Universitätsmedizin Berlin) "Structural and spectroscopic studies on rhodopsin activation and interaction with G protein" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Gebhard Schertler (ETH Zürich) "Structure of a constitutively active rhodopsin mutant: Insights into receptor activation" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Speaker TBA: To be selected from GRS talks (TBA) |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:25 pm | Speaker TBA: To be selected from GRS posters (TBA) |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PHYTOCHROME STRUCTURE/FUNCTION RELATIONSHIPS |
| Discussion Leader: J. Clark Lagarias (UC Davis) |
9:00 am - 9:30 am | J. Clark Lagarias (UC Davis) "Molecular Mechanisms of Light Perception by Phytochromes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Richard Vierstra (University of Wisconsin - Madison) "Atomic Perspectives on Phytochrome Photoconversion" |
10:05 am - 10:15 am | Discussion |
10:15 am | Coffee Break / Group Photo |
10:45 am - 11:10 am | Lars-Oliver Essen (Phillips Universität - Marburg) "Cph1 & Cph2: Two families of cyanobacterial photochromes" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Andrew Ulijasz (University of Wisconsin - Milwaukee) "The Cyanochromes: Phytochrome-Like Photoreceptors With An Unusual Blue-Green Twist" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Akira Nagatani (Kyoto University) "Structural basis of phytochrome A specific functions" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | CRYPTOCHROMES |
| Discussion Leader: Alfred Batschauer (Phillips Universität - Marburg) |
5:30 pm - 5:35 pm | Alfred Batschauer (Phillips Universität - Marburg) "Open challenges in cryptochromes" |
5:35 pm - 6:00 pm | Margaret Ahmad (CNRS) "Cryptochrome photoreceptor mechanisms of light activation" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Steven Reppert (UMass Medical Center) "Monarch butterfly cryptochromes mediate magnetoreception through an unconventional photochemical mechanism" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Dongping Zhong (Ohio State University) "Ultrafast dynamics and anionic states of the flavin cofactor in cryptochrome" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:25 pm | Speaker TBA: Promoted poster talk (TBA) |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MICROBIAL RHODOPSINS |
| Discussion Leader: Hartmut Luecke (UC Irvine) |
9:00 am - 9:05 am | Hartmut Luecke (UC Irvine) "Open challenges in microbial rhodopsins" |
9:05 am - 9:30 am | John Spudich (UT Houston Medical School) "Microbial rhodopsins: Receptors, channels, and pumps from a single design" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Klaus Gewert (Ruhr Universität - Bochum) "Proton transfer via protein bound water molecules" |
10:05 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:10 am | Joachim Heberle (Free University of Berlin) "The vibrations of channelrhodopsin-2" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Peter Hegemann (Humboldt University) "Tailoring the Channelrhodopsin properties" |
11:45 am - 11:55 am | Discussion |
11:30 am - 12:10 pm | Ed Boyden (MIT) "Tools for controlling neural and biological processes enabled by ecological diversity of microbial opsins" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | BLUF DOMAINS |
| Discussion Leader: Ilme Schlichting (Max Planck Institute for Medical Research, Heidelberg) |
5:30 pm - 6:00 pm | Ilme Schilchting (Max Planck Institute for Medical Research, Heidelberg) "BLUF proteins: On downstream signaling" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Carl Bauer (Indiana University) "Defining dark and lit state of the BLUF photoreceptors AppA and PixD" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Mineo Iseki (Hayama Center for Advanced Studies) "Single molecule studies of the structure and function of photoactivated adenylyl cyclase (PAC), a sensor for photomovement in Euglena" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:25 pm | Speaker TBA: Promoted poster talk (TBA) |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOPHYSICAL METHODS AS APPLIED TO PHOTOSENSORS |
| Discussion Leader: Klaas Hellingwerf (University of Amsterdam) |
9:00 am - 9:05 am | Klaas Hellingwerf (University of Amsterdam) "Open challenges for novel biophysical applications to photosensors" |
9:05 am - 9:30 am | Keith Moffat (University of Chicago) "Optogenetics: The structure and function of natural and engineered photoreceptors" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Tom Sakmar (Rockefeller University) "Using genetically-encoded non-natural amino acids to study rhodopsin structure and function" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:30 am - 10:55 am | Wayne Hubbell (UCLA) "Protein flexibility in signal transduction: A view from the EPR time window" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Masahide Terazima (Kyoto University) "Spectrally hidden reaction dynamics of photosensor proteins" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Marloes Groot (Vrije Universiteit, Amsterdam) "The role of the protein in the isomerization reaction of photoactive yellow protein" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Jocelyne Vreede (University of Amsterdam) "Predicting the reaction coordinates of millisecond light-induced conformational changes in Photoactive Yellow Protein" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | PHOTOSENSORY COMPONENTS OF BIOLOGICAL CLOCKS |
| Discussion Leader: Jay Dunlap (Dartmouth University School of Medicine) |
5:30 pm - 5:35 pm | Jay Dunlap (Dartmouth University School of Medicine) "Open challenges in biological clocks" |
5:35 pm - 5:55 pm | Jennifer Loros (Dartmouth University School of Medicine) "How the VVD photoreceptor works in Neurospora" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Dave Somers (Ohio State University) "Post-translational regulation of the circadian clock" |
6:20 pm - 6:25 pm | Discussion |
6:25 pm - 6:45 pm | Amita Seghal (University of Pennsylvania) "Photic entrainment of the circadian clock in Drosophila" |
6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Samer Hattar (Johns Hopkins University) "Vision beyond image formation: The role of melanopsin cells in regulating mammalian physiology" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:20 pm | Speaker TBA: Promoted poster talk (TBA) |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LOV DOMAINS: STRUCTURE, MECHANISM AND ENGINEERING |
| Discussion Leader: Aba Losi (University of Parma) |
9:00 am - 9:30 am | Aba Losi (University of Parma) "News and views for prokaryotic LOV proteins: From signaling to phylogeny" |
9:30 am - 9:35 am | Discussion |
9:35 am - 10:00 am | John Christie (University of Glasgow) "Application of LOV domains as fluorescent reporters" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:35 am - 11:00 am | Masamitsu Wada (Kyushu University) "Factors controlling the existence of chlorplast actin filaments involved in chloroplast movement" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Andreas Möglich (University of Chicago) "Signal integration in PAS histidine kinases" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Hartmut Luecke (UC Irvine) |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Wolfgang Gärtner (Max Planck Institute for Bioinorganic Chemistry, Mülheim) "Novel LOV domain proteins from screening data bases and environment" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | PHYTOCHROME SIGNALING |
| Discussion Leader: Eberhard Schaefer (University of Freiburg) |
5:30 pm - 6:00 pm | Eberhard Schaefer (University of Freiburg) "Early events in phy signaling and modeling of HIR" |
6:00 pm - 6:05 pm | Discussion |
6:05 pm - 6:25 pm | Jorge Casal (University of Buenos Aires) "Signalling by phytochrome A under sustained compared to transient excitation" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Giltsu Choi (KAIST) "Inhibition of PIFs by phytochromes" |
6:50 pm - 6:55 pm | Discussion |
6:55 pm - 7:15 pm | Chris Voigt (UC San Francisco) "Fast, high-resolution induction of signaling networks using light" |
7:15 pm - 7:20 pm | Discussion |
7:20 pm - 7:25 pm | Speaker TBA: Promoted poster talk (TBA) |
7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |