Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Signaling Across Boundaries
Discussion Leader: Kristen Naegle (University of Virginia, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Stacey Finley (University of Southern California, United States)
"Tumor-Immune Interactions in Breast Tumors: Insights from Agent-Based Modeling"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Ioannis Zervantonakis (University of Pittsburgh, United States)
"Modeling Cancer-Fibroblast Crosstalk and Resistance to HER2-Targeted Therapy in Breast Cancer: an Integrated Experimental-Computational Approach to Target Pro-Survival Signaling"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Elana Fertig (Johns Hopkins University, United States)
"Spatial Multi-omics for Pancreatic Carcinogenesis and Therapeutic Response"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechano-Genomics
Discussion Leader: John Marko (Northwestern University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Karmella Haynes (Emory University, United States)
"Probing the Epigenetic Plasticity of Genes in Triple Negative Breast Cancer Cells with Engineered Chromatin Proteins"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Dennis Discher (University of Pennsylvania, United States)
"Physical Stressors in Genetic Change Versus Cell Death"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Michelle Baird (NHLBI-National Institutes of Health, United States)
"Excess Cholesterol Synthesis Driven by Upregulation of Lamin B Receptor Causes Nuclear Envelope Fragility in Metastatic Melanoma"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Abigail Loneker (University of Pennsylvania, United States)
"Lipid Droplets are Intracellular Mechanical Stressors That Promote Hepatocyte Dedifferentiation Through Nuclear Deformation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Rohin Banerji (Boston University, United States)
"Micromechanics of Tumor Nodules in Functional Lungs Probed in Real-Time at Cellular Resolution Using a Novel Crystal Ribcage"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Brittany Schutrum (Cornell University, United States)
"Engineered Tumor-Stroma Models to Study the Role of Hyaluronic Acid in Breast Cancer Invasion"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Claudia Fischbach (Cornell University, United States) and Nastaran Zahir (National Cancer Institute, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cells at Rest: Proliferation and Dormancy
Discussion Leader: Maria Sosa (Icahn School of Medicine at Mount Sinai Hospital, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Scott Manalis (Massachusetts Institute of Technology, United States)
"Single-Cell Biophysical Approaches for Cancer Research"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jeremy Copperman (Oregon Health and Science University, United States)
"Recovering Hidden Information From Live-Cell Trajectories to Predict the Biological Pathway Activity Underlying Cell State Change Decisions"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Amaia Cipitria (Biodonostia Health Research Institute, Spain)
"Biomaterials in Cancer Dormancy and Early Metastasis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Shelly Peyton (UMass Amherst, United States)
"Engineered Environments to Understand and Quantify Cellular Dormancy and Reactivation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Biophysics of Tumor Immunity
Discussion Leader: Heiko Enderling (Moffitt Cancer Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Li Tang (EPFL, Switzerland)
"Overcoming A Mechanical Immune Checkpoint for Enhanced Cancer Immunotherapy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Kolade Adebowale (Harvard University, United States)
"Elucidating Biophysical Cues Shaping Immunity"
10:00 am - 10:05 am
Discussion
10:05 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Eduardo Reategui (The Ohio State University, United States)
"Relative RNA Characterization in Single Extracellular Vesicles and Particles from Complex Biofluids for Cancer Diagnostics"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Ankita Jha (National Institutes of Health, United States)
"Front-Rear Polarity Establishment During Bleb-Based Migration Under Confinement"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
W. Gregory Sawyer (University of Florida, United States)
"The Tumor Microenvironment in Three-Dimensions: Immune Cells, Cytokines, and Tumor Invasion"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Daniel Bergman (University of Michigan, United States)
"Dysregulated FGFR3 Signaling Alters Immune Landscape in Bladder Cancer and Presents Therapeutic Possibilities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cells on the Move
Discussion Leader: Kandice Tanner (NIH, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Kimberly Stroka (University of Maryland, College Park, United States)
"The Biophysical Role of Aquaporins in Tumor Cell Migration"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Pere Roca-Cusachs (Institute for Bioengineering of Catalonia, Spain)
"Intermediate Filaments as Regulators of ECM-Nucleus Mechanosignalling"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Gordana Vunjak-Novakovic (Columbia University, United States)
"Cancer Patient on a Chip"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Mechanics: Transport and Forces Across Scales
Discussion Leader: Brendan Harley (University of Illinois, Urbana Champaign, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Malisa Sarntinoranont (University of Florida, United States)
"Biphasic Modeling of Glioma Biomechanics and Transport"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jeremy Teo (New York University Abu Dhabi, United Arab Emirates)
"Aligned Collagen Fibers Triggers Differential Fibroblast and Macrophage Behaviors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
LaDeidra Monet Roberts (Virginia Tech, United States)
"A Motley Crew: Linking Intratumoral Heterogeneity to Invasion and Interstitial Fluid Flow (IFF) in Glioma"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
Josef Käs (Leipzig University, Germany)
"Static Morphology of Tumor Fronts Predicts Dynamics of Tumor Progression"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Alexander Cartagena-Rivera (National Institute of Biomedical Imaging and Bioengineering, United States)
"Multiplexed Nanoscale Viscoelastic Mapping of Melanoma Cells as a Biomarker of Tumor Progression and Metastasis"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Hadi Nia (Boston University, United States)
"Probing Lung Function in Health and Disease at High Spatiotemporal Resolution Using a Novel Crystal Ribcage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Physics of Metabolism
Discussion Leader: Michael Murrell (Yale University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Cynthia Reinhart-King (Vanderbilt University, United States)
"The Intersection of Metabolism and Migration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Vasudha Srivastava (University of California, San Francisco, United States)
"Configurational Entropy is a Fundamental Driver of Tissue Structural Heterogeneity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michelle Dawson (Brown University, United States)
"Physical and Metabolic Aspects of Therapy Induced Senescence and Polyploidy in an Evolving Tumor Microenvironment"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Claudia Fischbach (Cornell University, United States)
"Mechanical Properties of Adipose Tissue and Their Effect on Breast Cancer"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Stromal Dynamics
Discussion Leader: Catherine Whittington (Worcester Polytechnic Institute, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Ece Ozturk (Koc University, Turkey)
"Engineering Biomimetic Lung Tumor Models"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Stephanie Seidlits (The University of Texas at Austin, United States)
"Effects of Matrix Signaling Through CD44 on Glioblastoma Cell Metabolism, Proliferation, and Invasion"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
David Basanta (Moffitt Cancer Center, United States)
"The Yin and Yang of Stromal Interactions with Cancer During Treatment"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Aashrith Saraswathibhatla (Stanford University, United States)
"Cell Volume Expansion and Local Contractility Mediate Basement Membrane Breaching in Breast Cancer"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Ashlee Ford Versypt (University at Buffalo, The State University of New York, United States)
"Agent-Based Modeling of Cancer Cell Migration in Response to Tumor Microenvironmental Signals"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Applications Toward Personalized Detection and Therapy
Discussion Leader: Erica Pratt (Boston University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Andrea Hawkins-Daarud (Mayo Clinic Arizona, United States)
"Every Patient Deserves Their Own Equation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Orly Alter (University of Utah, United States)
"Mathematical Discovery and Computational and Experimental Validation of Whole-Genome Genotype–Survival and Response to Treatment Phenotype Relationships in Cancer"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Sara Nizzero (Houston Methodist Research Institute, United States)
"Heterogeneity of Mechano-Physical Biomarkers Drive Outcome in Breast Cancer: A Quantitative Spatial Analysis Approach"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Clayton Yates (Tuskegee University, United States)
"Immuno-Oncology Targets in Patients with African Ancestry"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure