Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Phosphate in Health and Disease
Discussion Leaders: Aline Martin (Northwestern University, United States) and Carsten Wagner (University of Zurich, Switzerland)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Orson Moe (UT Southwestern Medical Center, United States)
"The Complexity of Phosphate Physiology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Joachim Ix (University of California San Diego, United States)
"The Systemic Pathology of Abnormal Phosphate Homeostasis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Organs Contributing to Phosphate Homeostasis and Endocrine Regulators
Discussion Leaders: Heini Murer (University of Zürich, Switzerland) and Outi Makitie (University of Helsinki, Finland)
9:00 am - 9:25 am
Reinhold Erben (University of Veterinary Medicine Vienna, Austria)
"Endocrine Regulation of Phosphate Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Nati Hernando (University Zurich, Switzerland)
"Intestinal Absorption of Phosphate: Transcellular and Paracellular Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Hiroko Segawa (Tokushima University, Japan)
"Renal Phosphate Handling"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Monzur Murshed (McGill University, Canada)
"Phosphate and Bone Mineralization"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Clemens Bergwitz (Yale School of Medicine, United States)
"Overexpression of the Phosphate Transporter PIT1 in Muscle Promotes Increased Muscle Mass, Energy Expenditure and Endurance Running in Male Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Maren Leifheit-Nestler (Hannover Medical School, Germany)
"High Inorganic Phosphate Intake and the Regulation of Phosphate Homeostasis in Mice"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Eleanor Lederer (University of Texas Southwestern Medical Center, United States) and Erica Clinkenbeard (Indiana University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic Disorders of Phosphate Homeostasis
Discussion Leaders: Farzana Perwad (UCSF, United States) and Cassianne Robinson-Cohen (Vanderbilt University Medical Center, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Michael Econs (Indiana University School of Medicine Division of Endocrinology, United States)
"Genetic Disorders of Phosphate in Bone"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Qiaoli Li (Thomas Jefferson University, United States)
"Pyrophosphate in Genetic Disorders of Ectopic Calcification"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Harald Jueppner (Massachusetts General Hospital, United States)
"Genetic Disorders Affecting Parathyroid Hormone Action"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organ Crosstalk in the Regulation of Phosphate Balance
Discussion Leaders: Myles Wolf (Duke University, United States) and Petra Simic (Massachusetts General Hospital, United States)
9:00 am - 9:20 am
Kenneth White (Indiana University School of Medicine, United States)
"FGF23 and the Kidney"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Valentin David (Northwestern University, United States)
"FGF23 and Bone"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Chou-Long Huang (University of Iowa Carver College of Medicine, United States)
"Soluble Klotho"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Hannes Olauson (Karolinska Institutet, Sweden)
"Tissue Klotho"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Hirotaka Komaba (Tokai University School of Medicine, Japan)
"Bone-Specific Overexpression of Membrane Klotho Induces FGF23"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Demetrios Braddock (Yale University, United States)
"Bone Targeted ENPP1 Suppresses Plasma FGF23 in ENPP1 Deficient Mice, Supporting the Existence of Pyrophosphate Sensors in the Bone Regulating FGF23 Transcription"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Jane Joy Thomas (Northwestern University, United States)
"Liver-Specific miR-122 Stimulates Bone Derived FGF23 Cleavage in Iron Deficient Mice"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Kamal Hamid (University of Zurich, Switzerland)
"Phosphate Restriction Curbs Mortality and Blunts Rise in Plasma FGF23 and IL-6 in Murine Acute Kidney Injury"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phosphate Sensing, Uptake, Signaling and Effects in Cells
Discussion Leaders: Michael Mannstadt (MGH/Harvard, United States) and Clemens Bergwitz (Yale School of Medicine, United States)
7:30 pm - 7:50 pm
R. Todd Alexander (The University of Alberta, Canada)
"Phosphate Source Determines the Route of Intestinal Absorption"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Laurent Beck (Chest Institute Research Unit, France)
"Extra- and Intra-Cellular Phosphate Sensing Pathways in Mammals"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
George Beck (Emory University, United States)
"Extracellular Inorganic Phosphate Stimulated Cellular and Molecular Signaling"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Eugene Rhee (Massachusetts General Hospital, United States)
"Phosphate Sensing in the Mammalian Kidney"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathologic Effects of Phosphate on Cells
Discussion Leaders: Jason Stubbs (University of Kansas Medical Center, United States) and Mohammed Razzaque (LECOM, United States)
9:00 am - 9:25 am
Elena Aikawa (Brigham and Women's Hospital / Harvard Medical School, United States)
"Phosphate and Vascular Calcification"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Daniel Bondeson (The Broad Institute of MIT and Harvard, United States)
"Phosphate Dysregulation as a Novel Therapeutic Strategy in Cancer"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
Tally Naveh-Many (Hadassah-Hebrew University Medical Center, Israel)
"Posttranscriptional Regulation of Parathyroid Hormone Gene Expression by Phosphate and Uremia"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
Timo Rieg (University of South Florida, United States)
"Novel Ways in Regulating Phosphate Homeostasis"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Lauriane HIVERT (UMR INSERM U1059 – SAINBIOSE - LBTO, France)
"The Sibling Protein Bsp Regulates Gut Phosphate Absorption"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Seth Bollenbecker (University of Alabama at Birmingham, United States)
"Linking CKD and Lung Injury: Dysregulated Phosphate Homeostasis Stimulates Inflammation in the Bronchial Epithelium and Exacerbates the Effects of Cigarette Smoke Exposure"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Valery Khramtsov (West Virginia University, United States)
"Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression and Aggressiveness"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biology of Phosphate Containing Complexes
Discussion Leaders: Steve Holt (SEHA Kidney Care, United Arab Emirates) and Sagar Nigwekar (Mass General Hospital, United States)
7:30 pm - 7:50 pm
Makoto Kuro-o (Jichi Medical University, Japan)
"Calciprotein Particles in Health and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Marc Vervloet (Amsterdam UMC, Netherlands Antilles)
"Do Calciprotein Particles Mediate Vasculotoxicity of Phosphate?"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Dorothea Fiedler (Leibniz-Institute for Molecular Pharmacology (FMP), Germany)
"The Role of Inositol Pyrophosphates in Cellular Phosphate and Energy Homeostasis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andreas Mayer (Université de Lausanne, Switzerland)
"The Multi-Layered Approach of Yeast to Phosphate Homeostasis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Measurement and Models
Discussion Leaders: Michel Chonchol (University of Colorado, United States) and Dorothea Fiedler (Leibniz-Institute for Molecular Pharmacology (FMP), Germany)
9:00 am - 9:20 am
Rosa Maria Affonso Moysés (Universidade de São Paulo, Brazil)
"Dietary Phosphate and Animal Models"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Orlando Gutierrez (University of Alabama at Birmingham, United States)
"Dietary Phosphate Intake in Humans in the Modern Era"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Michael Collins (National Institute of Dental and Craniofacial Research, NIH, United States)
"Clinical and Preclinical Assessment of Phosphate Mediated Extraosseous Calcification"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Johan Thevelein (KU Leuven, VIB and NovelYeast bv, Belgium)
"Phosphate and Similar Nutrient Starvation-Induced Transceptors in Yeast"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jieyu Chen (University of Saskatchewan, Canada)
"Phosphate Localization in Live Plants, at the Cellular to Whole-Plant Levels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Angel Orte (University of Granada, Spain)
"Pi-FLIM - A Novel Method to Assess Intracellular Phosphate"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diet, Microbiome and Intestinal Phosphate Absorption
Discussion Leaders: Ziad Massy (University Hospital Ambroise Paré ans UVSQ, France) and Jaime Uribarri (Icahn School of Medicine at Mount Sinai, United States)
7:30 pm - 8:00 pm
Tamara Isakova (Northwestern University, United States)
"Designing Human Studies to Examine Phosphate Homeostasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Kathleen Hill Gallant (University of Minnesota, United States)
"Dietary Phosphate: Bioaccessibility Versus Bioavailability and the Effect on Balance"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Annabel Biruete (Purdue University and Indiana University School of Medicine, United States)
"The Impact of the Gut Microbiome on Intestinal Phosphate Absorption"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
