SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Receptors in Thrombosis and Fibrinolysis |
| Discussion Leaders: Edward Plow (The Cleveland Clinic Foundation, Cleveland, Ohio) & Michael Holinstat (Vanderbilt University Medical Center, Nashville, TN) |
7:35 pm - 7:40 pm | Edward Plow (Introduction) |
7:40 pm - 8:20 pm | Keynote Speaker: Shaun Coughlin (University of California, San Francisco)
"Protease activated receptors (PARs) in vascular biology and beyond" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Lindsey Miles (Scripps Research Institute, La Jolla)
"Probing cellular proteomes for transmembrane plasminogen receptors" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Michael Ploug (Finsen Laboratory, Copenhagen, Denmark)
"How the urokinase receptor engages different ligands" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Informal Social |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Inflammation, Pathogenesis and Host Defense |
| Discussion Leaders: William Goldman (Washington University School of Medicine, St Louis) & Kim Baeten (University of Aberdeen, United Kingdom) |
9:00 am - 9:05 am | William Goldman (Introduction) |
9:05 am - 9:25 am | Wyndham Latham (Northwestern University Feinberg School of Medicine, Chicago, IL)
"Extracellular proteolysis during primary pneumonic plague" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Stephen Smiley (Trudeau Institute, New York)
"Immune regulation of fibrinolysis during infection" |
10:00 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Jay Degen (Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio)
"Genetic modification of thrombin-mediated proteolysis and innate immunity" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Charles Esmon (Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma)
"Cellular assembly and functions of the protein C system" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Francis Castellino (University of Notre Dame, Notre Dame, Indiana)
"DIC and enhanced inflammation in LPS-treated Protein C-deficient mice" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (even numbered posters presented) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mechanisms of Dysregulated Proteolysis |
| Discussion Leaders: Francis Castellino (University of Notre Dame, Notre Dame, Indiana) & Riku Das (The Cleveland Clinic Foundation, Cleveland, Ohio) |
7:30 pm - 7:35 pm | Francis Castellino (Introduction) |
7:35 pm - 8:00 pm | Katherine Hajjar (Weill Medical College at Cornell, New York)
"The Annexin A2 system and vascular function in vivo" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Silvia D'Alessio (Universita Vita Salute San Raffaele, Milano, Italy)
"Urokinase Receptor deficient mice are deficient in skin wound healing and are protected from skin carcinogenesis: connection to skin stem cells" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Sidney Strickland (The Rockefeller University, New York)
"The role of fibrin in Alzheimer's Disease" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Informal Social |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Proteolytic Pathways |
| Discussion Leaders: Vincent Ellis (University of East Anglia, Norfolk, United Kingdom) & Peter Kosa (National Institutes of Health, NIDCR, Bethesda, Maryland) |
9:00 am - 9:05 am | Vincent Ellis (Introduction) |
9:05 am - 9:25 am | Roman Szabo (National Institutes of Health, NIDCR, Bethesda, Maryland)
"Matriptase and its inhibitors - balancing cell surface proteolysis during tissue morphogenesis and cancer" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Daniel Kirchhofer (Genentech, Inc., South San Francisco, California)
"The transmembrane serine protease hepsin activates pro-hepatocyte growth factor (HGF) and pro-urokinase plasminogen activator (uPA) and promotes tumor progression" |
10:00 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Vincent Ellis (University of East Anglia, Norfolk, United Kingdom)
"Cellular regulation of transmembrane serine protease activity" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Paul Bock (Vanderbilt University School of Medicine, Nashville, Tennessee)
"von Willebrand Factor Binding Protein is a member of the Zymogen Activator and Adhesion Protein (ZAAP) family" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Jeffrey Smith (Burnham Institute for Medical Research, La Jolla, California)
"Unique strategies for predicting and measuring proteolysis: toward proteolytic networks" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (odd numbered posters presented) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Proteolysis in Tumor Biology |
| Discussion Leaders: Steven Gonias (University of California, San Diego, California) & Jennifer Lilla (University of California, San Francisco) |
7:30 pm - 7:35 pm | Steven Gonias (Introduction) |
7:35 pm - 8:00 pm | Harold Chapman (University of California, San Francisco, California)
"The urokinase receptor and integrin interactions in lung cancer cell signaling" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Sharon Stack (University of Missouri, Columbia, Missouri)
"Adhesion regulated proteolysis in ovarian carcinoma" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Peter Friedl (University of Wuerzburg, Wuerzberg, Germany)
"Tissue degradation during individual and collective invasion" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Informal Social |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neurobiology and Sensory Perception |
| Discussion Leaders: Sidney Strickland (Rockefeller University, New York) & Andre Samson (Monash University, Melbourne, Australia) |
9:00 am - 9:05 am | Sidney Strickland (Introduction) |
9:05 am - 9:25 am | Katerina Akassoglou (University of California, San Diego)
"Fibrinogen functions in the nervous system" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Dan Lawrence (University of Michigan Medical School, Ann Arbor, Michigan)
"Regulation of the blood brain barrier during ischemic stroke" |
10:00 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Michel Guipponi (University Hospital of Geneva, Switzerland)
"Analysis of the role of type II transmembrane serine proteases in hearing loss" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Wendy Campana (University of California, San Diego, California)
"LRP-1 is a multifunctional regulator during peripheral nerve injury and neuropathic pain" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Stella Tsirka (University at Stony Brook, Stony Brook, New York)
"Tissue plasminogen activator (tPA) and the glial scar" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
12:30 pm - 6:00 pm | Afternoon excursion to Solvang, "Sunny Fields" of Denmark (Optional) |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Late Breaking Hot Topics from Abstracts |
| Discussion Leaders: Thomas Bugge (National Institutes of Health, NIDCR, Bethesda, Maryland), Niels Behrendt (Rigshospitalet, Copenhagen, Denmark) & Tina Kousted (University of Aarhus, Denmark) |
7:30 pm - 7:40 pm | Lina Basel-Vanagaite (Schneider Children's Medical Center of Israel, Petah Tikva, Israel)
"A novel autosomal recessive ichthyosis with hypotrichosis (ARIH) syndrome is caused by a mutation in ST14, encoding type II transmembrane serine protease Matriptase" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Matthias Hammerschmidt (Max-Planck Insitute of Immunobiology, Freiburg, Germany)
"Inactivation of serine protease Matriptase-1a by its inhibitor HAI-1 is required for epithelial integrity of the zebrafish epidermis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Mingdong Huang (Beth Israel Deaconess Medical Center and Harvard Medical School, Massachusetts)
"Structural origin of the species specificity of uPA-uPAR interaction revealed by the crystal structure of the murine uPA-uPAR complex" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Peter Gross (McMaster University, Ontario, Canada)
"Leukocyte uPAR and PSGL-1 play a role in arteriolar fibrinolysis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | David A. Dichek (University of Washington, Seattle)
"Macrophage-Expressed uPA, Plasminogen, and uPAR enhance the progression of murine atherosclerosis" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Kumar Shanmukhappa (Cincinnati Children's Hospital Medical Center, Ohio)
"Constitutive activated cMet rescues the defect in liver repair observed in Plasminogen-deficient mice" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Manuel Yepes (Emory University, Georgia)
"The interaction between Tissue-type Plasminogen Activator (tPA) and the Low Density Lipoprotein Receptor-Related Protein (LRP) mediates Akt phosphorylation during cerebral ischemia" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Teresa Wagner (University Of Washington, Seattle)
"Role of uPARAP/Endo180 In alveolar hemorrhage during acute lung injury" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Informal Social |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Atherosclerosis and Cardiovascular Disease |
| Discussion Leaders: Dudley Strickland (University of Maryland School of Medicine, Baltimore) & Jennifer Gibbons (University of North Carolina, Chapel Hill) |
9:00 am - 9:05 am | Dudley Strickland (Introduction) |
9:05 am - 9:25 am | Qingyu Wu (Clevelend Clinic Foundation, Cleveland, Ohio)
"The cardiac serine protease corin in hypertension and heart disease" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:00 am | David Ginsburg (University of Michigan School of Medicine, Ann Arbor)
"Whole genome approaches to cardiovascular disease in model organisms" |
10:00 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Dudley Strickland (University of Maryland School of Medicine, Baltimore, Maryland)
"Modulation of inflammatory pathways by LRP" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Jay Horton (University of Texas Southwestern Medical Center at Dallas)
"PCSK9, a secreted protease with a non-protease function" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Douglas Vaughan (Vanderbilt University School of Medicine, Nashville, TN)
"PAI-1: a vascular rheostat for thrombosis and atherosclerosis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Farewell Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protease Engineering and Pharmacological Intervention |
| Discussion Leaders: Paul Bock (Vanderbilt University School of Medicine, Nashville, TN) & Rajkumar Ganesan (Genentech Inc., South San Francisco, CA) |
7:30 pm - 7:35 pm | Paul Bock (Introduction) |
7:35 pm - 8:00 pm | Edwin Madison (Catalyst Biosciences, South San Francisco, CA)
"Engineering the activity and specificity of proteases" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Thomas Bugge (National Institutes of Health, NIDCR, Bethesda, Maryland)
"Reengineering bacterial cytotoxins for protease imaging and tumor targeting" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Peter Andreasen (University of Aarhus, Aahrus, Denmark)
"New principles for pharmacological intervention with the plasminogen activation system" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Informal Social |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |