SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:30 pm | Keynote Speaker |
7:40 pm - 8:25 pm | Roger Tsien (University of California, San Diego)
"Building Molecules to Image and Treat Disease"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | Imaging and Proteases |
| Discussion Leaders: Peter Friedl (The University of Texas) and Dimitrios Davalos (Gladstone Institutes) |
8:30 pm - 8:55 pm | Peter Friedl (The University of Texas)
"Mechanics of Protease-Independent Tumor Cell Migration"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Charles Craik (University of California, San Francisco)
"Using Pericellular Proteolysis as a Functional Biomarker for Monitoring Tumorigenesis"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Neurobiology of Disease |
| Discussion Leaders: Robert Medcalf (Monash University) and Flavie Lesept (INSERM) |
9:00 am - 9:25 am | Robert Medcalf (Monash University)
"The Immunosuppressive Effect of Plasmin: Implications for Traumatic Brain Injury"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Stella Tsirka (Stony Brook University)
"Microglial Proteases Regulate Synaptic Stability"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Sidney Strickland (The Rockefeller University)
"Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Manuel Yepes (Emory University)
"Plasminogen Activators in Neurological Repair"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Robert Pawlak (University of Exeter)
"Control of Anxiety and Fear by Extracellular Proteolysis in the Amygdala"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Flash Talks (Selected from Abstracts to Highlight Posters) |
|
- Alban Gaultier (University of Virginia)
"LRP1 Is an Inhibitor of Remyelination"
- Christian Schachtrup (University of Freiburg)
"Fibrinogen Regulates the Differentiation of Adult Neural Stem Cells into Astrocytes After Vascular Damage"
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12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure and Function |
| Discussion Leaders: Cynthia Peterson (University of Tennessee) and Diana Abu-Ssaydeh (Monash University) |
7:30 pm - 7:55 pm | Cynthia Peterson (University of Tennessee)
"Fine-Tuning Serpin Activity: Effects of Ligands on the Conformation & Dynamics of PAI-1"
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Leonid Medved (University of Maryland)
"Interaction of Fibrin with Endothelial Cell Receptors and Wound Healing"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Robert Parmer (University of California, San Diego)
"Plasminogen Activation and Sodium Homeostasis"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Ruby Law (Monash University)
"Structure and Function Studies of Plasminogen Glycoforms"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation and Host Defense |
| Discussion Leaders: Jay Degen (University of Cincinnati) and Katiuchia Sales (NIH) |
9:00 am - 9:25 am | Matthew Flick (University of Cincinnati)
"Coagulation Factors, Metabolic Inflammation, and Fatty Liver Disease"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Selen Catania (University of Maryland)
"Multifaceted Role of LRP1 in Vascular Integrity: Regulation of Inflammation and Proteolysis in the Vasculature"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Elizabeth Gardiner (Monash University)
"Shear-Regulated Proteolysis of Adhesion Receptors in Thrombosis and Haemostasis"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Edward Plow (Lerner Research Institute/Cleveland Clinic)
"Plasminogen as a Regulator of Gene Expression and Lipid Metabolism in Macrophages"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Partho Ghosh (University of California, San Diego)
"How Streptococcal M1 Protein Co-Opts Fibrinogen to Cause Toxic Shock"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Flash Talks (Selected from Abstracts to Highlight Posters) |
|
- Michael Motley (NIH)
"An Endocytic Pathway that Mediates Extravascular Fibrin Clearance In Vivo"
- Jae Kyu Ryu (Gladstone Institutes)
"Targeting Fibrin-Induced Activation of Innate Immunity"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cardiovascular Biology |
| Discussion Leaders: Katherine Hajjar (Weill Cornell Medical College) and Maarten Hendrickx (KU Leuven) |
7:30 pm - 7:55 pm | Katherine Hajjar (Weill Cornell Medical College)
"The Annexin A2 System in Vascular Homeostasis and Innate Immunity"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Tetsu Urano (Hamamatsu University School of Medicine)
"Regulatory Mechanism of the Expression of Plasmin Activity on Vascular Endothelial Cells Revealed by Imaging Technique"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Victoria Ploplis (University of Notre Dame)
"Components of the Plasminogen Activation System and Endothelial Cell Function"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Colin Kretz (University of Michigan)
"A Comprehensive Substrate Recognition Landscape for ADAMTS13 is Revealed by Coupling Substrate Phage Display with High-Throughput Sequencing"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:30 am - 12:30 pm | Biological Engineering and Therapeutics |
| Discussion Leaders: Netanel Korin (Harvard University) and Paul Declerck (KU Leuven)
|
9:00 am - 9:25 am | Netanel Korin (Harvard University)
"Shear-Activated Nano-Therapeutics for Thrombolytic Therapies"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dan Lawrence (University of Michigan)
"Improving Stroke Treatment by Understanding the Opposing Activities of Tissue Plasminogen Activator in Ischemic Stroke"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Peter Caravan (Harvard Medical School)
"Multimodality Fibrin-Specific Imaging Probes"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Eduardo Angles-Cano (INSERM - Paris Descartes University)
"Plasminogen Activation by Microvesicles: Tiny Messengers in Fibrinolytic and Proteolytic Crosstalk"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Shaun Coughlin (University of California, San Francisco)
"Protease-Activated Receptors: Discovery to Drug"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Flash Talks (Selected from Abstracts to Highlight Posters) |
|
- Matthias Unseld (Medical University Vienna)
"Tumor-Derived Soluble uPAR Downregulates the Tumor Suppressor PTEN in Endothelial Cells to Promote Angiogenesis In Vivo"
- Bu-Taek Lim (Hanyang University)
"Rapid Diagnosis of Matrix Metalloproteinase Activity Using Bioluminescence Resonance Energy Transfer-Based Nanosensors"
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12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late Breaking Topics |
| Discussion Leaders: Lindsey Miles (The Scripps Research Institute) and
Dudley Strickland (University of Maryland)
|
7:30 pm - 7:40 pm | Dennis Vivien (INSERM)
"tPA-Ergic Neurons: Trafficking of tPA and Its Potential Role in Synaptic Plasticity"
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7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | TBA
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7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Mark Petersen (Gladstone Institutes, University of California, San Francisco)
"Inhibition of Remyelination by Blood-Derived Factors: A Role for Fibrinogen in Oligodendrocyte Precursor Cell Differentiation"
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8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Wendy Campana (University of California, San Diego)
"Genetic Deletion of Low-Density Lipoprotein Receptor-Related Protein (LRP1) in Schwann Cells Regulates Axonal Regeneration"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Eric Mullins (Cincinnati Children's Research Foundation)
"Plasminogen Deficiency is Protective from Paralysis in a Murine Model of Multiple Sclerosis"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | William Fay (University of Missouri)
"Plasminogen Activator Inhibitor-1 Inhibits Vascular Endothelial Growth Factor (VEGF) Signaling by Uncoupling VEGF Receptor-2-αVβ3 Integrin Cross-Talk"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Dianaly Au (University of Maryland School of Medicine)
"Macrophage LRP1 Modulates Lipid Homeostasis and Diet-Induced Hepatic Inflammation"
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9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Marguerite Buzza (University of Maryland School of Medicine)
"Inflammation-Induced Loss of the Prostasin-Matriptase Barrier Promoting Pathway in Intestinal Epithelium Contributes to the Pathogenesis of Colitis"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tissue Remodeling and Regeneration |
| Discussion Leaders: Thomas Bugge (NIH) and Valentina De Lorenzi (The FIRC Institute for Molecular Oncology) |
9:00 am - 9:25 am | Daniel Madsen (NIH)
"A Novel M2-Like Macrophage-Mediated Intracellular Collagen Degradation Pathway Identified by Intravital Imaging"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Qingyu Wu (Lerner Research Institute (Cleveland Clinic))
"The Protease Corin in Blood Vessel Remodeling"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Marie-Christine Bouton (Unite INSERM U698)
"Protease Nexin-1, a Serpin Involved in Tissue Remodeling"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Tor Ny (Umea University)
"The Role of Plasminogen as a Regulator of Wound Healing"
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11:35 am - 11:45 am | Discussion |
11:45 am - 12:10 pm | Toni Antalis (University of Maryland)
"Membrane-Anchored Serine Proteases in Inflammation and Protease Activator Receptor Signaling"
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12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | Flash Talks (Selected from Abstracts to Highlight Posters) |
|
- Lars Engelholm (The Finsen Laboratory/BRIC)
"Internalization of Collagens for Lysosomal Degradation Mediated by Members of the Mannose Receptor Family"
- Yuko Tashima (National Cerebral and Cardiovascular Center)
"Generation and Characterization of Homozygous Plasminogen-Tochigi Mutant Mice Bearing Reduced Fibrinolytic Activity"
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tumor Biology and Angiogenesis |
| Discussion Leaders: Karin List (Wayne State University) and Efrat Harel (University of California, San Francisco) |
7:30 pm - 7:55 pm | Karin List (Wayne State University)
"Matriptase Mediated C-Met Signaling is Critical for Breast Cancer Progression"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Steve Gonias (University of California, San Diego)
"Comparing the Activity of Membrane-Anchored and Soluble uPAR in Cancer"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Sharon Stack (University of Notre Dame)
"Serine Proteinase Regulation in Invasive Oral Squamous Cell Carcinoma"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Veronica Placencio (Children's Hospital Los Angeles)
"Pharmacologic Inhibition of PAI-1 by TM5275 Increases Intrinsic Apoptosis in Cancer Cells and Inhibits Macrophage Migration"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |