| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Extracellular Proteolysis and Women's Health |
| Discussion Leaders: Robert Medcalf (Monash University, Australia), Tor Ny (Umea University, Sweden) and Marta Kubala (Children's Hospital Los Angeles, USA) |
| 7:40 pm - 8:25 pm | Zena Werb (University of California, San Francisco, USA)
"Extracellular Proteases: Regulators of Extracellular Signal Transduction in Development and Disease" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Qingyu Wu (Lerner Research Institute, Cleveland Clinic, USA)
"Molecular Mechanisms in Pregnancy-Associated Diseases: Proteases and Beyond" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Karin List (Wayne State University School of Medicine, USA)
"Role of Membrane-Anchored Serine Proteases in Carcinogenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Neurobiology: From Synaptic Function to Neurological Disease |
| Discussion Leaders: Sidney Strickland (The Rockefeller University, USA) and Coralie Brifault (University of California, San Diego, USA) |
| 9:00 am - 9:35 am | Manuel Yepes (Emory University, USA)
"Plasminogen Activators and Synaptic Function" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Joachim Herz (University of Texas Southwestern Medical Center, USA)
"Proteolysis and the Regulation of Synaptic Transmission" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Wendy Campana (University of California, San Diego, USA)
"Regulation of Schwann Cell Physiology by LRP1: Role in Neuroinflammation, Regeneration and Neuropathic Pain" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Jae Kyu Ryu (Gladstone Institutes, University of California, San Francisco, USA)
"Fibrin and CNS Innate Immunity in Neurologic Diseases" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Stella Tsirka (Stony Brook University, USA)
"Microglial Proteases in CNS Disease" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Katerina Akassoglou (Gladstone Institutes, University of California, San Francisco, USA) and Katiuchia Sales (University of Sao Paulo, Brazil) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structure-Function of Proteases, Receptors and Inhibitors |
| Discussion Leaders: Daniel Lawrence (University of Michigan, USA) and Agnieszka Jendroszek (Aarhus University, Denmark) |
| 7:30 pm - 7:50 pm | Ruby Law (Monash University, Australia)
"Structural Studies on Plasminogen Modulators" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Colin Kretz (University of Michigan, USA)
"Defining the Substrate Specificity of ADAMTS13 Using High Throughput Protease Profiling" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Morten Beck Trelle (University of Southern Denmark, Denmark)
"Understanding PAI-1 Unfolding and Its Functional Implications" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Nicolai Sidenius (IFOM, FIRC Institute for Molecular Oncology, Italy)
"The Proteolytic Functions of Urokinase in the Regulation of Cell Adhesion Signaling" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Proteolysis in Cancer Dissemination |
| Discussion Leaders: David Waisman (Dalhousie University, Canada) and Fausto Varela (Wayne State University, USA) |
| 9:00 am - 9:35 am | Steven Gonias (University of California, San Diego, USA)
"LRP1 Functions as a Plasminogen Activator Receptor to Regulate Inflammation and Cancer Angiogenesis" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Elena Deryugina (The Scripps Research Institute, USA)
"Proteolytic Modifications and Functional Activation of Transmembrane Molecules Involved in Metastatic Dissemination of Cancer Cells" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Malgorzata Wygrecka (Justus Liebig University, Germany)
"Intriguing Mode of Action of Moonlighting Proteins in Cancer Cell Invasion" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Toni Antalis (University of Maryland School of Medicine, USA)
"Potent Anti-Tumor Activity of Membrane-Anchored Serine Protease-Activated Engineered Anthrax Toxins" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Charles Craik (University of California, San Francisco, USA)
"Development of Antibody Based Probes for Detecting Active Cancer Associated Serine Proteases" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Insights into Protease Functions in the Cardiovascular System |
| Discussion Leaders: William Fay (University of Missouri, USA) and Andre Samson (University of Sydney, Australia) |
| 7:30 pm - 7:50 pm | Nicola Mutch (University of Aberdeen, United Kingdom)
"Modulation of Fibrinolysis by Platelet-Derived Polyphosphate" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Imre Varju (Semmelweis University, Hungary)
"The Role of DNA, Histones and Neutrophil Extracellular Traps in the Formation and Resolution of Thrombi" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Edward Plow (Cleveland Clinic Lerner Research Institute, USA)
"Histone 2B: The Forgotten Plasminogen Receptor" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Henrik Juergensen (National Institutes of Health, USA)
"A CCR2 Macrophage Endocytic Pathway Mediates Extravascular Fibrin Clearance In Vivo" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Inflammation and Infection |
| Discussion Leaders: David Ginsburg (University of Michigan Medical School, USA) and Shaun Lee (University of Notre Dame, USA) |
| 9:00 am - 9:35 am | Lirlandia Pires de Sousa (Federal University of Minas Gerais, Brazil)
"Plasmin Induces Macrophage Reprogramming and Contributes to Features of the Resolution of Inflammation" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | David Corry (Baylor College of Medicine, USA)
"The Fibrinogen-TLR4 Axis and the Control of Innate Immunity" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:15 am | Tione Buranda (University of New Mexico School of Medicine, USA)
"Inflammation, P2Y2R, PAI-1 and Pathogenesis of Hantavirus Infections" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:45 am | Frank Castellino (University of Notre Dame, USA)
"Conscription of the Human Fibrinolytic System by S. pyogenes to Enhance Its Virulence" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Jay Degen (Cincinnati Children's Hospital Medical Center, USA)
"Genetically Disabling Fibrin Formation in Mice and the Bacterial Pathogen-Host Interface" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Late-Breaking Topics: The Cutting Edge |
| Discussion Leaders: Matthew Flick (Cincinnati Children's Hospital Medical Center, USA) and Vincent Ellis (University of East Anglia, United Kingdom) |
| 7:30 pm - 7:40 pm | Riku Das (Cleveland Clinic Health System, USA)
"Dietary Fat Promotes Intestinal Barrier Dysfunction and Inflammatory Polyp Formation in Plasminogen Deficient Mice" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Jonathan Schoenecker (Vanderbilt University Medical Center, USA)
"Plasmin Prevents Muscle Transformation into Bone After Injury" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Wendy Mars (University of Pittsburgh, USA)
"Absence of Hepatocellular LRP1 in Aged Animals Leads to Defective Biliary Regeneration Following Bile Duct Ligation" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Sumeda Nandadasa (Cleveland Clinic Lerner Research Institute, USA)
"Sculpting the Mammalian Embryo, Role of ADAMTS9-Mediated ECM Proteolysis During Embryogenesis" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Eugenia Salcedo (University of California, San Francisco, USA)
"Global Profiling of Extracellular Proteolysis as a Molecular Stratification Tool for Breast Cancer" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Mingdong Huang (Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, China)
"Crystal Structures of Urokinase Receptor Associated Protein (uPARAP, or endo180)" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Marie Ranson (University of Wollongong, Australia)
"Pancreatic Cancer Invasion and Stromal Remodling Is Dependent on Urokinase and Regulated by Serpin B2" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Maria Patrizia Stoppelli (National Research Council, Italy)
"Tumor-Stroma Crosstalk: Factors Secreted by c-Myc Expressing Epithelial Cells Increase Fibroblast Mobilization and Activation Through IGF-1R and uPAR" |
| 9:25 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Therapeutics / New Technologies |
| Discussion Leaders: Samy Meroueh (Indiana University, USA) and Thomas Bonnard (Australian Center for Blood Diseases, Australia) |
| 9:00 am - 9:35 am | Paul Declerck (University of Leuven, Belgium)
"Development of Novel Profibrinolytics" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Robert Lazarus (Genentech, Inc., USA)
"Activators and Inhibitors of HGF/Met and MSP/Ron Signaling" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Christian Heinis (École Polytechnique Fédérale de Lausanne, Switzerland)
"Peptide Macrocycle Inhibitors of uPA and MMP-2" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Toshio Miyata (Tohoku University, Japan)
"Inhibition of PAI-1 Regulates Cellular Regeneration and Senescence" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Haibo Jiang (The University of Western Australia, Australia)
"High Resolution Molecular Imaging with the NanoSIMS" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Role of Extracellular Proteolysis in Senescence and Aging |
| Discussion Leaders: Douglas Vaughan (Northwestern University, USA) and Zhen Gao (Cincinnati Children's Hospital Medical Center, USA) |
| 7:30 pm - 7:50 pm | Katherine Hajjar (Weill Cornell Medical College, USA)
"Annexin A2 and Innate Immunity" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Douglas Vaughan (Northwestern University, USA)
"Impact of a Private Mutation in PAI-1 on Aging in Humans: Insights from the Berne Amish Kindred" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Selen Catania (University of Maryland, USA)
"Mechanisms Regulating Aneurysm Formation" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Linda Fredriksson (Karolinska Institutet, Sweden)
"The Neurovascular Unit in Neurologic Disease" |
| 9:20 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
