Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Next or New Opportunities in the Plasminogen Activation and Extracellular Proteolysis Field
Session in memory of Ed Reich and Russell Doolittle.
Discussion Leader: Sidney Strickland (The Rockefeller University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
Roger Lijnen (Center for Molecular and Vascular Biology, KU Leuven, Belgium)
"Understanding the Molecular Regulation of Plasminogen Activation as a Key to Future Fibrinolysis Research"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Steven Gonias (University of California, San Diego, USA)
"Fibrinolysis Research: A Look Back and Forward"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cardiovascular Function and Coagulopathies
Discussion Leaders: Katherine Hajjar (Weill Cornell Medicine, USA) and Eric Mullins (Cincinnati Children's Research Foundation, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Elizabeth Gardiner (Australian National University, Australia)
"Proteolytic Regulation of Platelet Receptor Levels in Patients with Cardiovascular Complications"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
James Luyendyk (Michigan State University, USA)
"Mechanisms Linking Fibrinogen and Fibrinolysis to Liver Repair"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Jeremy Lagrange (INSERM 1116, France)
"Alpha-2-Macroglobulin and Hemostasis Disorders in Chronic Inflammatory Diseases"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Claire Whyte (University of Aberdeen, United Kingdom)
"The Activated Platelet Membrane: A Key Site for Plasminogen Activation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Hunter Moore (University of Colorado Denver, USA)
"The Evolution of Defining Fibrinolysis Dysfunction Following Severe Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Laurent Mosnier (The Scripps Research Institute, USA)
"The Role of TAFI in Hemophilic Arthropathy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Nicola Mutch (University of Aberdeen, United Kingdom) and Matthew Flick (University of North Carolina at Chapel Hill, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Musculoskeletal Disease
Discussion Leaders: Daniel Lawrence (University of Michigan, USA) and Paul Kim (McMaster University / Thrombosis and Atherosclerosis Research Institute (TaARI), Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Jonathan Schoenecker (Vanderbilt University Medical Center, USA)
"The Multifaceted Role of Fibrin/Fibrinolysis in Musculoskeletal Biology"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Naoyuki Kawao (Kindai University, Japan)
"Roles of Plasminogen Activator Inhibitor-1 in Bone Metabolism"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Lakmali Silva (National Institute of Dental and Craniofacial Research, NIH, USA)
"Fibrin Is a Critical Regulator of Mucosal Immunopathology"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Dada Pisconti (Stony Brook University, USA)
"The Yin and Yang of Neutrophil Elastase in Muscle Regeneration and Dystrophy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Diseases and Aging
Discussion Leaders: Selen Catania (University of Maryland, USA) and Yao Yao (University of Georgia, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Mari Kaartinen (McGill University, Canada)
"Association of Adipose Tissue Factor XIII-A with Metabolic Health in Mice and Humans"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
"Assessing In Situ Plasmin Generation in Health and Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Rafal Pawlinski (University of North Carolina at Chapel Hill, USA)
"Prothrombotic Complications and Resistance to tPA-Mediated Fibrinolysis in Sickle Cell Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Bryan Copple (Michigan State University, USA)
"Regulation of Macrophages by Plasmin During Liver Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Erin Norris (The Rockefeller University, USA)
"Protective Effects of a High Fat Diet on Alzheimer's Disease Pathophysiology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Khalid Bajou (University of Sharjah, United Arab Emirates)
"14K Fragment of Growth Hormone and Its Derived Peptides Promote Fibrinolysis and Protect from Thrombosis by Binding Plasminogen Activator Inhibitor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Breanne Gibson (Vanderbilt University, USA)
"The Time-Dependent Role of Plasmin in Muscle Repair and New Considerations for Antifibrinolytic Drug Administration Following Trauma and Surgery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Signaling
Discussion Leaders: Toni Antalis (University of Maryland School of Medicine, USA) and Michael Ploug (Rigshospitalet, Denmark)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Beate Heissig (Juntendo University Graduate School of Medicine, Japan)
"The Fibrinolytic System Orchestrates the Development of Inflammation and Inflammation-Associated Carcinogenesis in the Proteolytic Niche"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Michael Boffa (The University of Western Ontario, Canada)
"TAFI and Thrombomodulin as Inhibitors of Breast Cancer Metastasis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Marie Ranson (University of Wollongong, Australia)
"PA System in Skin Cancer Progression"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Kseniia Rubina (Moscow State University, Russia)
"Urokinase Receptor as a 'Trap' for Urokinase: Binding of uPA to uPAR Prevents Nuclear Translocation of uPA and EMT in Neuroblastoma Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Technologies and Therapeutic Advances
Discussion Leaders: Katerina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA) and Li Zhang (University of Maryland School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Keith Neeves (University of Colorado Denver Anschutz Medical Campus, USA)
"Magnetically Powered Microbots for Fibrinolysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Evi Stavrou (Case Western Reserve University, USA)
"uPAR Inhibitory Nanomedicine for Targeted Treatment of Sterile Inflammatory Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Yi Yang (University of North Carolina at Chapel Hill, USA)
"Thrombin Signaling Promotes Pancreatic Adenocarcinoma Through PAR-1-Dependent Immune Evasion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Salim Hayek (University of Michigan, USA)
"Defining High-Risk Heart Failure with Preserved Ejection Fraction Through Inflammatory Burden: The Role of sUPAR"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Jason McCarthy (Masonic Medical Research Institute, USA)
"Multi-Channel Fluorescent Imaging of Hemostatic Proteases for the Monitoring of Therapeutic Efficacy"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Benoit Ho-Tin-Noe (Laboratory for Vascular Translational Science (INSERM U1148), France)
"Resistance to Fibrinolysis and New Thrombolytic Strategies: Insights from Intravital Microscopy, Microfluidics and Ex Vivo Thrombolysis Assays"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yuko Suzuki (Hamamatsu University School of Medicine, Japan)
"Spatiotemporal Regulation of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Activation on Activated Platelets"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ariel Diaz (Emory University, USA)
"Urokinase Regulates N-Cadherin-Mediated Synaptic Formation in the Ischemic Brain"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leaders: Lindsey Miles (Scripps Research Institute, USA) and Robert Medcalf (Monash University, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Christopher Barrett (Massachusetts Institute of Technology / Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Plasmin(ogen) and the Traumatically Injured Patient: Friend or Foe?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Ze Zheng (Columbia University, USA)
"Hepatocyte-Derived tPA Regulates Systemic Fibrinolysis"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Tom Sisson (University of Michigan, USA)
"PAI-1 Drives the Development of Lung Fibrosis Through Novel Protein Interactions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Shaun Lee (University of Notre Dame, USA)
"The Role of Localized Proteolytic Environments in Group A Streptococcal Pathogenesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Marguerite Buzza (University of Maryland School of Medicine, USA)
"Membrane-Anchored Serine Proteases in the Regulation of Vascular Permeability"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infection and Immunity
Discussion Leaders: Dudley Strickland (University of Maryland School of Medicine, USA) and Manuel Yepes (Yerkes National Primate Research Center, Emory University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Jochen Reiser (Rush University, USA)
"SuPAR as Endogenous Immunotoxin for the Kidney"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Patricia Liaw (McMaster University, Canada)
"Extracellular Proteases in Sepsis: Translating Basic Research to Precision Medicine"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Andrey Komissarov (University of Texas Health Science Center at Tyler, USA)
"Plasminogen Activator Inhibitor-1 (PAI-1) Targeted Fibrinolytic Therapy in Rabbit Empyema Model"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Irit Sagi (Weizmann Institute of Science, Israel)
"New Horizons in Translating Selective Anti-MMP Biological Inhibitors into the Clinic"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tione Buranda (University of New Mexico School of Medicine, USA)
"Derangements of uPA and PAI-1 Activity in Severe Cases of Hantavirus Cardiopulmonary Syndrome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ana Flores-Mireles (University of Notre Dame, USA)
"Modulation of Fibrinogen/Fibrin Levels Affects the Outcome of Enterococcal Catheter-Associated Urinary Tract Infections"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Joseph Palumbo (Cincinnati Children's Hospital Medical Center, USA)
"Fibrinogen Deficiency Leads to Stabilization of 14-3-3-Sigma and P53 Which Control Colorectal Adenocarcinoma Growth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurological and Neuropsychiatric Diseases
Discussion Leaders: Eri Kawashita (Kyoto Pharmaceutical University, Japan) and Denis Vivien (INSERM, France)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Mario Merlini (Gladstone Institute of Neurological Disease, USA)
"Cerebrovascular Pathology in Cognitive Impairment"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Linda Fredriksson (Karolinska Institutet, Sweden)
"tPA Modulation of the Blood-Brain Barrier"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Stephen Crocker (University of Connecticut School of Medicine, USA)
"Proteolytic Regulation of Glial Activation and Neuroinflammation"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Sara Martinez de Lizarrondo (INSERM U1237, France)
"New Thrombolytic Therapies for Ischemic Stroke"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
