Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Extracellular Proteolysis in Human Disease
Discussion Leaders: Dudley Strickland (University of Maryland School of Medicine, United States) and Victoria Ploplis (University of Notre Dame, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Introduction by Discussion Leader
8:05 pm - 8:40 pm
Francis Castellino (University of Notre Dame, United States)
"The Molecular Nature of Plasminogen Binding and Its Importance to Infectious Diseases"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
David Ginsburg (University of Michigan, United States)
"Plasminogen Activation and Extracellular Proteolysis: From Bedside to Bench and Back Again"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Thrombotic Disorders: From Basic Research to Clinical Management
Discussion Leaders: Daniel Lawrence (University of Michigan, United States) and Nicola Mutch (University of Aberdeen, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Ernest Moore (Ernest E Moore Shock Trauma Center at Denver Health, United States)
"Meeting the tPA Challenge: Use of Viscoelastic Tests to Guide Trauma Care"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ian Roberts (LSHTM, United Kingdom)
"The Story of Tranexamic Acid in Acute Severe Bleeding"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Jeffrey Weitz (McMaster University, Canada)
"A Novel Antiplasmin Inhibitor: From Preclinical Study to First in Human Evaluation"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Amy Shapiro (IHTC, United States)
"Clinical Manifestation of Plasminogen Deficiency"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tetsumei Urano (Shizuoka Graduate University of Public Health, Japan)
"Three Distinct Clot Lysis Assays to Detect Activities of Alpha2 Antiplasmin, PAI-1 and TM/TAFI: Their Applications to Assess TXA Necessity, PAI-1 Deficiency and Soluble TM Function in Plasma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Ze Zheng (Medical College of Wisconsin; Versiti Blood Research Institute , United States) and Paul Kim (Thrombosis and Atherosclerosis Research Institute (TaARI), Canada)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Musculoskeletal Diseases
Discussion Leaders: Robert Medcalf (Monash University, Australia) and Anton Ilich (UNC Chapel Hill, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Suneel Apte (Cleveland Clinic, United States)
"Integrated Forward and Reverse Degradomics of Human Diseases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Joshua Muia (Oklahoma State University Center for Health Sciences, United States)
"Metalloproteases ADAMTS13 and ADAMTS7: Substrate Processing and Regulation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Katherine Hajdu (Vanderbilt University Medical Center, United States)
"An Update of Plasminogen's Role in Orthopedic Injury"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammatory Diseases and Cancer: MMP, tPA and Plasminogen
Discussion Leaders: Antoine Dufour (University of Calgary, Canada) and Toni Antalis (University of Maryland School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Irit Sagi (The Weizmann Institute of Science, Israel)
"Targeting Pathophysiological Proteolytic Networks"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Rama Khokha (Princess Margaret Cancer Centre, Canada)
"Metalloprotease Inhibitors as Regulators of Tissue Stem Cell Fate"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
F. Xavier Gomis-Rüth (Molecular Biology Institute of Barcelona, CSIC, Spain)
"Structure-Function Studies of a Novel Bacterial MMP Inhibitor and of Celiacase: A Promising Therapeutic Agent for Celiac Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lindsey Miles (Scripps Research , United States)
"Functions of Plg-RKT Revealed by New Transgenic Mice"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Steven Gonias (UCSD, United States)
"Plasminogen Activator Receptors as Regulators of Cell Physiology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Karin List (Wayne State University school of Medicine, United States)
"Membrane-Anchored Serine Proteases in Epithelial Homeostasis and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Infection and Immunity
Discussion Leaders: Christopher Barrett (University of Nebraska Medical Center, United States) and Irit Sagi (The Weizmann Institute of Science, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Yogen Kanthi (National Institutes of Health, United States)
"Neutrophil Activation in Thromboinflammatory Syndromes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Shaun Lee (University of Notre Dame, United States)
"Group A Streptococcal Interactions with Blood System Components Revealed Through Live Imaging"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Yetunde Ayinuola (University of Notre Dame, United States)
"Recent Advances Identifying Structural Requirements for Accelerated Plasminogen Activation by Group A Streptococcus Plasminogen-Binding Proteins"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cerebrovascular Disease: From Imaging to Mechanism
Discussion Leaders: Sidney Strickland (The Rockefeller University, United States) and Wendy Campana (University of California, San Diego, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Katerina Akassoglou (Gladstone Institutes, UCSF, United States)
"Fibrin in Neurological Diseases: Mechanisms, Imaging, Therapeutics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Costantino Iadecola (Weill Cornell Medicine, United States)
"tPA’s Role in Neurovascular Function, Dysfunction and Alzheimer Pathology"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Ulf Eriksson (Karolinska Institutet, Sweden)
"Role of tPA in Metabolism: Implications in Stroke Therapy"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Denis Vivien (INSERM / Caen Normandie University Hospital, France)
"Latest Insights into tPA-Mediated NMDA Receptor Signaling via a Specific Knock-In Model"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Erin Norris (The Rockefeller University, United States)
"Targeting the Plasma Contact System to Ameliorate Vascular Dysfunction and Inflammation in Alzheimer’s Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Metabolic Diseases and Aging
Discussion Leaders: Katerina Akassoglou (Gladstone Institutes, UCSF, United States) and Matthew Flick (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Ana O'Loghlen (Centre for Biological Research (CIB); Spanish National Research Council (CSIC), Spain)
"Senescent Cells: Conversations with Their Neighbors"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Jim White (Duke University, United States)
"Plasminogen Secretion and Activation Enhance Muscle Repair During Caloric Restriction"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Woosuk Steve Hur (University of North Carolina at Chapel Hill, United States)
"Plasminogen and uPA in the Pathogenesis of Obesity and Metabolic Syndrome"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Emerging Technologies to Dissect Protease Function
Discussion Leaders: James Whisstock (Monash University, Australia) and Yetunde Ayinuola (University of Notre Dame, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Dennis Wolan (Genentech, United States)
"Application of Small Molecule and Biological Probes in the Discovery and Quantitation of IBD-Associated Proteases"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
John Weisel (University of Pennsylvania, United States)
"Fibrinolysis and Thrombolysis in Thrombus Resolution"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Peter Gross (McMaster University, TAARI, Canada)
"Novel Blood-Compatible Macromolecular Sensors for Proteases"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Anirban Sen Gupta (Case Western Reserve University, United States)
"Bioinspired Nanotherapeutics for Targeted Fibrinolysis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Laura Haynes (University of Michigan, United States)
"Deep Mutational Scanning to Map PAI-1 Functional Specificity and Evolution"
11:50 am - 12:00 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteases in Cutting-Edge Therapeutics
Discussion Leaders: Michael Ploug (Rigshospitalet and BRIC, Denmark) and Francesca Ferraresso (University of British Columbia, Canada)
7:30 pm - 7:45 pm
General Discussion
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Daniel Lawrence (University of Michigan, United States)
"Development of an Orally Active Small Molecule Inhibitor of PAI-1 for the Treatment of Systemic Sclerosis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Marie Ranson (University of Wollongong, Australia)
"Stopping Pancreatic Cancer in its Tracks: Anti-Metastatic and Anti-Immunosuppressive Effects of a Selective uPA Inhibitor in Preclinical Models"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Christopher Barrett (University of Nebraska Medical Center, United States)
"Plasminogen Deficiency and the Potential for Plasminogen Supplementation in Treatment of Pleural Space Infections"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
