| SATURDAY |
| 2:00 pm | Check-In Begins |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Presentation |
| 3:15 pm - 3:45 pm | Benjamin Cravatt (The Scripps Research Institute, La Jolla, CA)
"Activity-based Proteomics: Applications for Enzyme and Inhibitor Discovery" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Mechanisms of Pericellular Proteolysis |
| Discussion Leaders: Thomas H. Bugge (National Institutes of Health, Bethesda, USA) and Stine Friis (University of Copenhagen, Copenhagen, Denmark) |
| 7:30 pm - 7:45 pm | Kim M. Baeten (University of Aberdeen, Aberdeen, UK)
"Activation of Single-Chain Urokinase by Platelet-Associated Plasminogen: a Mechanism for Stimulation of Fibrinolysis by Platelets" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Hongqi Xin (Henry Ford Hospital, Detroit, USA)
"BMSCs Increase Astrocyte-Derived tPA Activity via Shh and TGFβ Pathways after Stroke which Facilitates Neurite Outgrowth" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Molly Rose Darragh (University of California, San Francisco, USA)
"Specific Targeting of cell Surface Serine Protease Activity for Tumor Detection in vivo" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Jingjing Jiang (Cleveland Clinic Foundation, Cleveland, USA)
"Ectodomain Shedding and Autocleavage of the Cardiac Membrane Protease Corin" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Loic Doeuvre (Université de Caen, Caen, France)
"Plasmin-Induced Release of Neuronal Microparticles: Biomarkers of Neuronal Outcome and Proteolytic Messengers" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Lawrence Thompson (University of Tennessee, Knoxville, USA)
"Metal Binding Induces Conformational Changes in the Structure of Human Plasminogen Activator Inhibitor-1 that Modulate Stability and Protease Inhibition" |
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Serine Proteases in Tissue Development, Homeostasis, and Disease |
| Discussion Leaders: Sharon Stack (University of Missouri, Columbia, USA) and Jae Kyu Ryu (Gladstone Institute of Neurological Disease, San Francisco, USA) |
| 9:00 am - 9:15 am | Selen Muratoglu (University of Maryland, Baltimore, USA)
"Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Linda Fredriksson (University of Michigan, Ann Arbor, USA)
"Deficiency of Platelet-Derived Growth Factor CC Leads to Abnormal Vascularization of the CNS" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Andreas Hald (Finsen Laboratory, Copenhagen, Denmark)
"Concurrent Ablation of MMP9 and Plasminogen Results in Lethal Inflammatory Mass Lesions in the Colon" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Marguerite S. Buzza (University of Maryland, Baltimore, USA)
"Matriptase Regulates Epithelial Barrier Formation in the Intestine" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 10:55 am | Ida K. Lund (Finsen Laboratory, Copenhagen, Denmark)
"Antibody-Mediated Targeting of the uPA Proteolytic Activity Neutralizes uPA Functions in vivo" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:15 am | Rym Abderrahmani (Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France)
"PAI-1 Influences Radiation-Induced Apoptosis in vivo and in vitro" |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:35 am | Ellen Vercauteren (Catholic University, Leuven, Belgium)
"Evaluation of the Profibrinolytic Properties of an Anti-TAFI Monoclonal Antibody in a Mouse Pulmonary Embolism Model" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Zhi Xu (University of Notre Dame, Notre Dame, USA)
"Plasminogen Activator Inhibitor-1 (PAI-1) is Cardioprotective in Mice by Maintaining Microvascular Integrity and Cardiac Architecture" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Elisabetta Mantuano (University of California, San Diego, USA)
"Rac1 and RhoA are Regulated Reciprocally Downstream of Low Density Lipoprotein Receptor-Related Protein (LRP1) to Control Schwann Cell Adhesion and Migration" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 3:30 pm | Poster Session II |
| 3:30 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
