| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:40 pm | Introductory Comments by GRC Site Staff |
| 3:40 pm - 3:50 pm | Welcome by the GRS Conference Chair |
| 3:50 pm - 4:30 pm | Molecular Mechanisms of Extracellular Proteolysis |
| Discussion Leaders: Roman Szabo (National Institutes of Health, Bethesda, MD, USA) and Ida Lund (Finsen Laboratory, Copenhagen, Denmark) |
| 3:50 pm - 4:05 pm | Colin Kretz (University Of Michigan, Ann Arbor, MI, USA)
"An unbiased substrate phage display screen identifies residues within the VWF A2 domain essential for proteolysis by ADAMTS13" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Tine Wyseure (Catholic University, Leuven, Belgium)
"Bispecific inhibition of TAFI and PAI-1 as a fibrinolytic enhancer" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I (odd numbered posters) |
| 6:00 pm | Dinner |
| 7:30 pm - 8:50 pm | Proteolytic Mechanisms in Cancer Biology |
| Discussion Leaders: Roman Szabo (National Institutes of Health, Bethesda, MD, USA) and Daniel Madsen (Finsen Laboratory Copenhagen, Denmark and National Institutes of Health, Bethesda, MD, USA) |
| 7:30 pm - 7:45 pm | Sai Duriseti (University of California, San Francisco, CA, USA)
"Imaging uPAR in Preclinical Models of Triple Negative Breast Cancer Using Human Antibodies" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Maria Melander (Finsen Laboratory, Copenhagen, Denmark)
"Experimental targeting of the collagen-receptor uPARAP/Endo180 in osteosarcoma mouse models" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Veronica Placencio (Children's Hospital, Los Angeles, CA, USA)
"Plasminogen activator inhibitor-1 inhibition induces apoptosis in cancer cells" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Ida Lund (Finsen Laboratory, Copenhagen, Denmark)
"Promising mAb-based anti-cancer therapy directed against mouse uPA" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:30 pm | Keynote Address |
| 8:50 pm - 9:20 pm | Sidney Strickland (The Rockefeller University, New York, NY, USA)
"Rethinking Dementia: From Dr. Alzheimer to the Present" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm - 12:00 am | GRS Social |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Proteolytic Functions in Physiology and Disease I |
| Discussion Leaders: Bradford Schwartz (University of Wisconsin, Madison, WI, USA) and Ekemini Udofa (University of Maryland, Baltimore, MD, USA) |
| 9:00 am - 9:15 am | Elamprakash Savariar (University of California, San Diego, CA, USA)
"In vivo imaging of extracellular proteases using FRET and protease targeted fluorescent peptides" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Chantelle Rein-Smith (University of North Carolina, Chapel Hill, NC, USA)
"Overexpression of the Tumor Suppressor p16INK4a Leads to Impaired Wound Healing in Mice" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Daniel Madsen (Finsen Laboratory Copenhagen, Denmark, National Institutes of Health, Bethesda, MD, USA)
"Endocytic collagen degradation: A novel mechanism involved in the protection against liver fibrosis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Harini Raghu (University of Cincinnati, New York, NY, USA)
"Plasminogen mediates both positive and negative effects on TNFα-driven arthritis through fibrinogen-dependent mechanisms" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Suzanne Siefert (University of Maryland, Baltimore, MD, USA)
"Two distinct roles of PAI-2 and PAI-1 in deep vein thrombosis" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Mesut Eren (Northwestern University, Chicago, IL, USA)
"PAI-1 is a critical determinant of accelerated aging in Klotho mice" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II (even numbered posters) |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:50 pm | Proteolytic Functions in Physiology and Disease II |
| Discussion Leaders: Bradford Schwartz (University of Wisconsin, Madison, WI, USA) and Mario Merlini (Gladstone Institutes, University of California, San Francisco, CA, USA) |
| 1:30 pm - 1:45 pm | Daria Zamolodchikov (The Rockefeller University, New York, NY, USA)
"Aβ delays fibrin clot lysis by altering fibrin structure and blocking plasminogen binding to fibrin" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Sumihisa Orita (University of California, San Diego, CA, USA)
"Conditional deletion of the LDL-receptor related protein (LRP1) in Schwann cells induces chronic neuropathic pain" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Jae Kyu Ryu (University of California, San Francisco, CA, USA)
"Regulation of CNS autoimmunity by BBB disruption" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms, discuss about the GRS experience, give feedback |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
