| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:40 pm | Introductory Comments by GRC Site Staff |
| 3:40 pm - 3:50 pm | Welcome by the GRS Conference Chairs |
| 3:50 pm - 4:30 pm | Molecular Mechanisms of Extracellular Proteolysis |
| Discussion Leaders: Andre Samson (Monash University, Melbourne, Australia) and Maria Melander (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
|
| 3:50 pm - 4:05 pm | Joel Bucci (University of Tennessee, Knoxville TN, USA)
"Pinpointing the Molecular Basis for Metal Effects on PAI-1"
|
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Yuko Tashima (National Cerebral and Cardiovascular Center Research Institute, Japan)
"Generation and Characterization of Homozygous Plasminogen-Tochigi Mutant Mice Bearing Reduced Fibrinolytic Activity" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I (odd-numbered posters) |
| 6:00 pm | Dinner |
| 7:30 pm - 8:50 pm | Molecular Mechanisms of Extracellular Proteolysis
(continued)
|
| Discussion Leaders: Andre Samson (Monash University, Melbourne, Australia) and Tine Thurison (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
|
| 7:30 pm - 7:45 pm | Valentina De Lorenzi (FIRC Institute of Molecular Oncology Foundation Milano, Italy)
"Urokinase Provides a Negative Feedback Between Plasminogen Activation and Cell Adhesion Through uPAR-Dependent Cleavage of Vitronectin" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Joni Prasad (University of Maryland, Baltimore, MD, USA)
"Genetic Deletion of LDL Receptor Family Members Supports Thrombus Resolution in a Mouse Model of DVT"
|
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Maria Melander (The Finsen Laboratory/BRIC, University of Copenhagen, Denmark)
"Targeting a Novel Bone Degradation Pathway in Osteosarcoma" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Deborah Francois (National Institute of Health and Medical Research, INSERM U698, Paris, France)
"Role of the Serpin Protease Nexin-1 in Tissue Remodeling Occurring During Pulmonary Fibrosis"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:30 pm | Keynote Session
|
| 8:50 pm - 9:20 pm | Sharon Stack (Professor in Chemistry & Biochemistry, Director of the Harper Cancer Research Institute, University of Notre Dame) |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Proteolytic Functions in Physiology and Disease
|
| Discussion Leaders: Katerina Akkasoglou and Erik Martin (University of Maryland, Baltimore, MD, USA)
|
| 9:00 am - 9:15 am | Diane Peters (NIDCR, National Institutes of Health, Bethesda, MD, USA)
"Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Survival Independent of Its Catalytic Activity" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Marguerite Buzza (University of Maryland, Baltimore, MD, USA)
"Inflammation-Induced Loss of the Prostasin-Matriptase Barrier Promoting Pathway in Intestinal Epithelium Contributes to the Pathogenesis of Colitis" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Katiuchia Sales (NIDCR, National Institutes of Health, Bethesda, MD, USA)
"Non-Hematopoietic PAR-2 is Essential for Matriptase-Driven Pre-Malignant Progression and Potentiation of Ras-Mediated Squamous Cell Carcinogenesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | TBA
|
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Amanda Boe (Northwestern University, Chicago, IL, USA)
"The Role of PAI-1 and NO in Aging-Related Pathology in Mice" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Maarten Hendrickx (Faculty of Pharmaceutical Sciences, KU Leuven, Belgium)
"Development of a Sandwich-Type ELISA for the Detection of Human Active Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) and Assessment in Patients" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II (even-numbered posters) |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:50 pm | Proteolytic Functions in Physiology and Disease (continued)
|
| Discussion Leaders: Katerina Akkasoglou (Gladstone Institute of Neurological Disease, University of California, San Francisco) and Diana Abu-Ssaydeh (Monash University, Melbourne, Australia)
|
| 1:30 pm - 1:45 pm | Tine Wyseure (Faculty of Pharmaceutical Sciences, KU Leuven, Belgium)
"Dual Targeting of TAFI and PAI-1 as a Novel Treatment for Acute Ischemic Stroke" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Patty Cunfer (University of Maryland, Baltimore, MD, USA)
"Investigation into the Mechanisms of LRP1-Mediated FVIII Clearance" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Dianaly Au (University of Maryland, Baltimore, MD, USA)
"Macrophage LRP1 Modulates Lipid Homeostasis and Diet-Induced Hepatic Inflammation" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 2:45 pm | Moamen Bydoun (Dalhousie University, Nova Scotia, Canada)
"The Plasminogen Receptor S100A10 Modulates Plasmin-Mediated Fibrinolysis in Acute Promyelocytic Leukemia" |
| 2:45 pm - 2:50 pm | Discussion |
| 2:50 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
