| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Extracellular Proteases in Tissue Remodelling |
| Discussion Leaders: Stephanie Moore (Vanderbilt University, USA) and Bruno Costa (Universidade Federal de Minas Gerais, Brazil) |
| 3:45 pm - 3:50 pm | Opening Remarks |
| 3:50 pm - 4:05 pm | Courtney Baker (Vanderbilt University, USA)
"Osteopontin Defiency Contributes to Heterotopic Ossification" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Sumeda Nandadasa (Cleveland Clinic Lerner Research Institute, USA)
"Sculpting the Mammalian Embryo, Role of ADAMTS9-Mediated ECM Proteolysis During Embryogenesis" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Extracellular Proteases in Inflammation and Immunity |
| Discussion Leaders: Christopher Overall (The University of British Columbia, Canada), Nicholas Mignemi (Vanderbilt University, USA), Eugenia Salcedo (University of California, San Francisco, USA) and Andre Samson (University of Sydney, Australia) |
| 7:30 pm - 7:45 pm | Juliana Priscila Vago da Silva (Universidade Federal de Minas Gerais, Brazil)
"Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Cameron Landers (Baylor College of Medicine, USA)
"The Pro-Inflammatory Role of Fibrinogen-TLR4 Signaling" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Dominik Draxler (Monash University, Central Clinical School, Australian Centre for Blood Diseases, Australia)
"Does the Plasminogen Activation System Contribute to Immunosuppression After Traumatic Brain Injury?" |
| 8:25 pm - 8:30 pm | Discussion |
| Keynote Session |
| 8:30 pm - 9:20 pm | Christopher Overall (The University of British Columbia, Canada)
"Systems Biology Deconvolution of the Pervasive Interactions of Proteases and Inhibitors Forming the Protease Web" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mentorship Component: Career Development |
| Discussion Leaders: Colin Kretz (University of Michigan, USA), Agnieszka Jendroszek (Aarhus University, Denmark), Mahsa Fallah (Umea University, Sweden) and Angela Colmone (Science Translational Medicine, USA) |
| 9:00 am - 9:45 am | Angela Colmone (Science Translational Medicine, USA)
"Advice and Insights About the Peer-Review Process from the Senior Editor of 'Science Translational Medicine'" |
| 9:45 am - 10:00 am | Discussion |
| Extracellular Proteases in Haemostasis and Thrombosis |
| 10:00 am - 10:15 am | Amelia Tomkins (Heart Research Institute, Australia)
"Thrombolysis for Recanalization in a Model of Carotid Artery Occlusion" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Thomas Bonnard (Australian Center for Blood Diseases, Australia)
"Thrombin Cleavable Micro Plasminogen Coupled to a Blocking Single-Chain Antibody Specific for Activated GPIIb/IIIa: A New Safe Thrombosis Treatment?" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Jathushan Palasubramaniam (Baker IDI Heart and Diabetes Institute, Australia)
"Activated-Platelet Targeted Fibrinolytic Drugs: Novel Targeted-Theranostic Microbubbles for Simultaneous Diagnosis, Treatment and Monitoring" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Extracellular Proteases in Cancer |
| Discussion Leaders: Marie Bay (Finsen Laboratory, Rigshospitalet, Denmark) and Fausto Varela (Wayne State University, USA) |
| 1:30 pm - 1:45 pm | Gregory Conway (University of Maryland School of Medicine, USA)
"The Role of Testisin and PAR-2 in Ovarian Cancer Angiogenic Signaling" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Andrew Murray (Wayne State University, USA)
"Identifying the Role of TMPRSS13 Protease in Breast Cancer" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Marta Kubala (Children's Hospital Los Angeles, USA)
"Tumor Derived PAI-1 Recruits Monocytes and Triggers Their Polarization Towards Alternatively Activated M2 Phenotype in an IL-6 - STAT3 Dependent Manner" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
