Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Plasminogen Activation and Extracellular Proteolysis in Therapy
Discussion Leaders: Joanna Cooper (University of Tennessee, USA) and Rene Girard (University of Texas Health Science Center at Tyler, USA)
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
Machteld Sillen (University of Leuven, Belgium)
"Elucidation of the Molecular Mechanism of Two Nanobodies that Inhibit PAI-1 Activity"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Benjamin Buckley (School of Chemistry, University of Wollongong, Australia)
"Repurposing Amiloride into uPA/NHE1 Dual Targeting Candidates for the Treatment of Metastatic Cancer"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Proteolysis in Regulation of Innate Immune Responses, Inflammation and Cancer / Keynote Session: Biophysical Properties of the Extracellular Matrix and Tumor Progression
Our keynote speaker will be Valerie Weaver of UCSF.
Discussion Leaders: Paola Merino (Emory University, USA) and Amanda Waller (The Research Institute at Nationwide Children's Hospital, USA)
7:30 pm - 7:45 pm
Elaine Da Silva (Ribeirão Preto Medical School, University of Sao Paulo, Brazil)
"Lympho-Epithelial Kazal-Type-Related Inhibitor (LEKTI) Inhibits Matriptase-Dependent Carcinogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Gregory Conway (University of Maryland School of Medicine, USA)
"Expression of Testisin Reduces Ovarian Tumor Metastasis Through a PAR-2 - Angiopoietin Signaling Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Lakmali Silva (National Institute of Dental and Craniofacial Research, NIH, USA)
"Fibrin Is a Critical Regulator of Immunopathology at the Oral Mucosal Barrier"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Valerie Weaver (University of California, San Francisco, USA)
"Biophysical Properties of the Extracellular Matrix and Tumor Progression"
9:15 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mentorship Component: Taking a Basic Science Discovery from Bench to Bedside / Extracellular Proteases in Thrombosis and Hemostasis
The Mentorship Component portion of the session will be a discussion panel with scientists who took the basic science discovery through from the lab to commercializing in form of founding a startup company or pushing the discovery to clinical trials.
Discussion Leaders: Mignote Chamiso (University of Texas Health Science Center at Tyler, USA), Juliana Priscila Vago da Silva (The Scripps Research Institute, USA), Marta Kubala (Children's Hospital Los Angeles, USA) and Amelia Tomkins (Heart Research Institute, Australia)
9:00 am - 10:00 am
Panel Discussion
Taking a Basic Science Discovery from Bench to Bedside: A Step by Step Guide for Early Career Scientists
Martin Broome (Children's Hospital Los Angeles, USA)
Paul Declerck (KU Leuven, Belgium)
Valerie Weaver (University of California, San Francisco, USA)
Stephen Fiacco (EvoRx Technologies, Inc., USA)
10:00 am - 10:15 am
Tierra Johnson (Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, USA)
"The Role of Plasminogen Activator Inhibitor Type-2 (PAI-2) in Modulating Venous Thrombus Resolution"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Maria Daglas (Monash University, Australia)
"The Influence of Plasmin on Blood-Brain Barrier Integrity and the Systemic and Local Immune Profile in Traumatic Brain Injury Is Gender-Dependent and Differentially Modulated by Tranexamic Acid"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
James Fowler (University of Texas Health Science Center at Tyler, USA)
"Effect of Ketamine on Lipopolysaccharide Induced Depression-Like Behavior in Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Extracellular Proteolysis in Tissue Development, Homeostasis, and Repair
Discussion Leaders: Brittany Aicher (University of Maryland School of Medicine, USA) and Zachary Huttinger (University of Michigan Medical School, USA)
1:30 pm - 1:45 pm
Allison Arai (University of Maryland School of Medicine, USA)
"Selective Deletion of LRP1 in Smooth Muscle Cells Results in Abdominal and Thoracic Aortic Aneurysms, TGF-Beta Activation, and Cerebral Artery Aneurysm"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Ariel Diaz (Emory University, USA)
"A Cross-Talk Between Neuronal Urokinase-Type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Synaptic Recovery in the Ischemic Brain"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Cameron Oram (University of British Columbia, Canada)
"Attenuation of Immune Cell-Secreted Serine Protease Granzyme B Reduced Tissue Damage and Improves Functional Recovery Following Spinal Cord Injury"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
