Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Global Approaches to Determining the Role of Extracellular Proteolysis in Disease
Discussion Leader: Nowah Afangbedji (Howard University, USA)
3:45 pm - 4:25 pm
Charles Craik (University of California, San Francisco, USA)
"Global Approaches to Determining the Role of Extracellular Proteolysis in Disease"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Roles and Therapeutic Implications of Extracellular Proteases in Cancer Biology and Neurobiology
Discussion Leader: Umar Ali (Illawarra Health and Medical Research Institute, University of Wollongong, Australia)
7:30 pm - 7:45 pm
Ariel Diaz (Emory University, USA)
"Urokinase Regulates N-Cadherin-Mediated Synaptic Formation in the Ischemic Brain"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Joachim Mertens (University of Antwerp, Belgium)
"Selective Inhibition of CPU Reduces Downstream Microvascular Thrombosis in an Experimental Rat Stroke Model"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Adam Miszta (Synapse Research Institute, The Netherlands)
"A Novel Plasmin Generation Assay to Monitor Pharmacodynamic Effects of Tranexamic Acid"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Benjamin Buckley (University of Wollongong, Australia)
"Developing of Potent Antimetastatic Candidates from the Oral Diuretic Amiloride"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Gabriel Vieira (University of Sao Paulo, Brazil)
"Proteolytic Profile of Pre-Malignant and Malignant Cervix Lesions"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Yi Yang (University of North Carolina at Chapel Hill, USA)
"Thrombin Signaling Promotes Pancreatic Adenocarcinoma Through PAR-1-Dependent Immune Evasion"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Roles of Extracellular Proteases Vascular Biology and Infectious Diseases
Discussion Leader: Dante Disharoon (Colorado School of Mines, USA)
9:00 am - 9:15 am
Allison Arai (University of Maryland School of Medicine, USA)
"De-Regulation of MMP-1 Levels in a Young Patient with Abdominal Aortic Aneurysms"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Rene Girard (University of Texas Health Science Center at Tyler, USA)
"Anything Could Happen: Development Time Affects PAI-1 and Cytokine Levels in the Rabbit Empyema Model"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Yetunde Ayinuola (University of Notre Dame, USA)
"Pattern D Streptococcus pyogenes , Strain AP53 Maintains Its Plasminogen-Binding Ability upon Deletion of Sortase-A but Lacks Other Virulence Determinants Needed for Survival in Host Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Oscar Negron (University of North Carolina at Chapel Hill, USA)
"A Human Fibrinogen Variant with Impaired Staphylococcus aureus Binding Function Promotes Host Survival During Septicemia in Mice"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Henry Vu (University of Notre Dame, USA)
"Real-Time Dynamics of Wound Healing with Group A Streptococcus and Plasminogen"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Collin Tran (National Institutes of Health, USA)
"Firin Is a Critical Regulator of Oral Mucosal Immunopathology"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Rigor and Reproducibility in the Study of Extracellular Proteases
Discussion Leader: Lakmali Silva (National Institute of Dental and Craniofacial Research, NIH, USA)
1:30 pm - 2:30 pm
Panel Discussion
Rigor and Reproducibility in the Study of Extracellular Proteases
Erin Norris (The Rockefeller University, USA)
Stella Tsirka (Stony Brook University, USA)
Charles Craik (University of California, San Francisco, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes