MONDAY, June 12
MORNING:
09:00 Opening Statements and Welcome
Macromolecular Interactions
Discussion Leaders: T.J. Thomas
09:15 Thomas Record, Department of Biochemistry, University of Wisconsin, Madison WI
"Roles of putrescine, Mg2+, and other cations in cytoplasmic electroneutrality and adaptation to osmotic stress
of Eschericia coli K-12: Implications for global regulation of Mg2+-RNA and protein-DNA interactios in vivo"
10:00 Coffee and Photograph
10:30 Joseph Parello, La Jolla Cancer Research Foundation, La Jolla CA
"The potential role of acetylation and deacetylation of polyamines in their interaction with chromatin"
11:15 Marvin L. Hackert, Dept. of Chemistry and Biochemistry The University of Texas at Austin, Austin
TX
"X-ray studies on ODCs and bacterial ADC"
EVENING
Polyamines and the Nervous System
Discussion Leaders: N. Seiler, C. Porter
07:30 Keith Williams, Department of Pharmacology, University of Pennsylvania School of Medicine,
Philadelphia PA
"The modulation of NMDA receptors"
08:15 Ian Blagbrough, School of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
"Synthetic and structural polyamine amides as receptor probes"
09:00 Poster Presentation
TUESDAY, June 13
MORNING
Metabolism and Transport
Discusion Leaders: R. Davis, C. Byus
09:00 Sarah Le Quesne, London School of Hygiene and Tropical Medicine London, United Kingdom
"Polyamine transport and metabolism in Trypanosome cruzi"
09:45 Kazuei Igarashi, Chiba University,Chiba Japan
"Transport mechanisms for polyamines in Eschericia coli and eukaryotic cells"
10:30 Coffee Break
10:50 Richard Poulin, Laboratory of Molecular endocrinology, Laval University, Ste Foy, Quebec
"Mechanistic and structural characterization of the mammalian polyamine transporter system"
11:30 Poster presentation
EVENING
Catabolism
Discussion Leaders: D. Morgan, H. Wallace
07:30 Catherine Coleman, Pennsylvania State Univ. College of Medicine, Hershey PA
"Structure and regulation of spermidine/spermine-N1-acetyltransferase"
08:15 Judith Klinman/ Danying Cai, University of California, Berkeley, Berkeley CA
"Structure/function of copper amine oxidases"
09:00 Poster Presentation
WEDNESDAY, June 14
MORNING
Functions of Polyamines
Discusion Leaders: A. Pegg, U. Bachrach
09:00 Celia and Herb Tabor, National Inst. of Diabetes and Digestive Kidney Diseases, Bethesda MD
"Current studies on in vivo functions of polyamines in Saccharomyces cerevisiae: (1) protection from the toxic
effects of oxygen, and (2) effects on protein synthesis (frameshifting)"
09:45 Myung H. Park, Laboratory of Cellular Development and Oncology National Institute of Dental
Research, Bethesda MD
"The hypusine biosynthetic enzymes and the essential role of eIF-5a modification in cell proliferation"
10:30 Coffee Break
10:50 Philip Coffino, University of California, San Francisco, San Francisco CA
"Life without polyamines: a worm's tale"
11:30 Poster Presentation
EVENING
Transgenic Plants and Animals
Discussion Leaders: O. Heby, H. Tabor
07:30 Juhani J„nne, Department of Biochemistry and Biotechnology, Kuopio University,Kuopio Finland
"Genetic engineering of polyamine metabolism in transgenic rodents"
08:15 S. Minocha, Department of Plant Biology, University of New Hampshire, Durham, NH
"Modulation of cellular polyamines in plants by transgenic expression"
09:00 Poster Presentation
THURSDAY, June 15
MORNING
Apoptosis and Cell Death
Discusion Leaders: E. H”ltt„, A. Desiderio
09:00 John L. Cleveland, Department of Biochemistry, St.Jude Childrens Research Hospital, Memphis
TN
"Ornithine decarboxylase as a mediator of c-myc induced apoptosis"
09:45 Chaim Kahana, Dept. of Molecular Genetics and Virology The Weizmann Institute, Rehovot, Israel
"Apoptosis is induced in ODC overproducing mouse melanoma cells by excessive accumulation of putrescine"
10:30 Coffee Break
10:50 D. Kramer, Roswell Park Cancer Institute, Buffalo NY
"Amplification of the AdoMet decarboxylase gene in CHO cells resistant to the potent anticancer agent,
CGP-48664"
11:30 Poster Presentation
EVENING
Clinical Aspects
Discussion Leaders: P. McCann, E. Gerner
07:30 Lawrence Marton, University of Wisconsin School of Medicine, Madison WI
"Polyamines and cancer: Clinical realities and possibilities"
08:15 Cyrus Bacchi, Haskins Laboratories, Pace University, New York NY
"Origins of parasite chemotherapy in polyamine metabolism"
09:00 Poster Presentation
FRIDAY, June 16
MORNING
Regulation of ODC and AdoMetDC Expression
Discussion Leaders: L. Persson
09:00 David R. Morris, University of Washington, Seattle WA
"Translational control of S-adenosyl methionine decarboxylase expression"
09:45 Shin-Ichi Hayashi and Senya Matsufuji, Dept. of Nutrition, The Jikei University School of Medicine,
Tokyo, Japan
"The biosynthesis and the role of the ODC antizyme in mammalian cells: polyamine-induced frameshifiting is
required for expression and regulation of the antizyme"
10:30 Coffee Break
10:50 Keiji Tanaka, Institute for Enzyme Research, University of Tokushima, Tokushima Japan
"The 26S proteasome is responsible for ODC turnover"
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