Sunday Evening
- 7:30 - Welcome and Opening Statements
POLYAMINE HOMEOSTASIS, AND APOPTOSIS
- Discussion Leaders:
- Heather Wallace (University of Aberdeen, Aberdeen, Scotland)
- Maria Desiderio (University of Milan, Milan, Italy)
- 7:45 - John Cleveland (St. Jude Children’s Hospital, Memphis, TN)
"Polyamines as Regulators of Apoptotic Pathways"
- 8:30 - Anthony Pegg (Pennsylvania State University, Hershey, PA)
"Regulation of polyamine levels in mammalian cells"
- 9:15 - Welcoming Reception
Monday Morning
METABOLIC ENZYMES
- Discussion Leaders:
- Philip Coffino (University of California, San Francisco, California)
- 9:00 - Senya Matsufuji (Jikei University School of Medicine, Tokyo, Japan)
"What happens to ODC before being degraded by the 26S proteasomes"
- 9:45 - Robert Casero (Johns Hopkins University School of Medicine, Baltimore, MD)
"Regulation of spermidine/spermine N1-acetyltransferase expression and its role in cytotoxicity"
- 10:30 - Coffee and Photograph
- 11:00 - Margaret Phillips (University of Texas, Dallas, TX)
"Structure/function studies of trypanosome ornithine decarboxylase"
- 11:45 - Poster Presentations (25 min.)
Monday Evening
PROTOZOAN PARASITES
- Discussion Leaders:
- Cyrus Bacchi (Pace University, New York, NY)
- Lo Persson (University of Lund, Lund, Sweden)
- 7:30 - Alan Fairlamb (University of Dundee, Dundee, Scotland, UK)
"Evaluation of the trypanothione pathway as a chemotherapeutic target"
- 8:15 - Nigel Yarlett (Pace University, New York, NY)
"Polyamine metabolism by Cryptosporidium parvum---an opportunistic parasite of AIDS patients"
- 9:00 - Poster Presentations (25 min.)
Tuesday Morning
POLYAMINE SYNTHESIS AND FUNCTION IN PLANTS
- Discussion Leaders:
- Subhash Minocha (UNiversity of New Hampshire, NH)
- Antonio Tiburcio (Univ. de Barcelona, Barcelona, Spain)
- 9:00 - Russell Malmberg (University of Georgia, Athens, GA)
"Genetic analysis of arginine decarboxylase in Arabidopsis thaliana"
- 9:45 - Rick Walden (Max Plank Institute Zuchtungsforschaft, Cologne, Germany)
"Studying the molecular basis of polyamine-induced cell division in plants"
- 10:30 - Coffee Break
- 10:50 - Amar Kumar (Scottish Crop Research Institute, Dundee, Scotland)
"Isolation, characterization and manipulation of the SAMDC gene of potato"
- 11:35 - Poster Presentations (25 min.)
Tuesday Evening
TRANSPORT
- Discussion Leaders:
- Susan Bardocz (The Rowett Research Institute, Aberdeen, Scotland)
- Craig Byus (University of California, Riverside, CA)
- 7:30 - Richard Poulin / Marie Audette (Laval University Medical Research Center, Quebec, Canada)
"Molecular characterization of the yeast and mammalian polyamine transport system: the yeast connection"
- 8:15 - Kazuei Igarashi (Chiba University, Chiba, Japan)
"Polyamine transport in E. coli and eukaryotic cells"
- 9:00 - Carl Porter (Roswell Park Cancer Institute, Buffalo, NY)
"Photoaffinity labeling of cell surface polyamine binding proteins"
- 9:40 - Poster Presentation (15 min.)
Wednesday Morning
CONTROL OF ION CHANNELS
- Discussion Leaders:
- Keith Williams (Univ. of Pennsylvania, Philadelphia, PA)
- Colin Nichols (Washington University, St. Louis, MO)
- 9:00 - Mary-Louise Roy (Case Western Reserve University, Cleveland, OH)
"Polyamines and Modulation of Cellular Excitability"
- 9:45 - Mark Mayer (National Institute of Child Health and Human Development, Bethesda, MD)
"Block of Glutamate Receptor Channels by Cytoplasmic Polyamines"
- 10:50 - Anne Delcour (University of Houston, Houston, TX)
"Polyamines as modulators of bacterial porins"
- 11:35 - Poster Presentations (25 min.)
Wednesday Evening
POLYAMINE ANALOGS---NEW CONCEPTS FOR ANTICANCER DRUGS
- Discussion Leaders:
- Debora Kramer (Roswell Park Cancer Institute, Buffalo, NY)
- 7:30 - Nikolaus Seiler (University of Rennes, Rennes, France)
"Dimethylsilane-tetramines: new structures with antitumor properties"
- 8:15 - Patrick Woster (Wayne State University, Detroit, MI)
"Structure/activity studies involving biologically active polyamine analogues"
- 9:00 - Laurence Marton and Benjamin Frydman (University of Wisconsin, Madison, WI)
"Chemistry and biology of conformationally restricted polyamines"
- 9:45 - Poster Presentation (15 min.)
Thursday Morning
ONCOGENES AND CANCER
- Discussion Leaders:
- Peter McCann (British Biotech Inc., Annapolis, MD)
- Stina Oredsson (University of Lund, Lund, Sweden)
- 9:00 - Erkki Hölttå (University of Helsinki, Helsinki, Finland)
"Polyamines - regulators of cell transformation?"
- 9:45 - Thomas O’Brien (Lankenau Medical Research Center, Wynnewood, PA)
"Ornithine decarboxylase is a susceptibility gene for skin cancer"
- 10:30 - Coffee Break
- 10:50 - Eugene Gerner (University of Arizona Health Science Center, Tucson, AZ)
"Modulation of polyamine pool sizes: Physiological consequences and a strategy for cancer chemoprevention"
- 11:35 - Poster Presentations (25 min.)
Thursday Evening
CELLULAR EFFECTS OF POLYAMINES
- Discussion Leaders:
- Olle Heby (Umea University, Umea, Sweden)
- Celia Tabor (National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD)
- 7:30 - Juhani Jänne (University of Kuopio, Kuopio, Finland) "Overexpression of spermidine/spermine acetyltransferase (SSAT) in transgenic mice"
- 8:15 - Kuang Yu Chen (Rutgers University, Piscataway, NJ) "Hypusine modification on eIF-5A: biochemistry and function"
- 9:00 - Recognitions
- 9:15 - Elections
- 9:30 - Farewell Party
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