| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Polyamines in New Arenas of Biology: Stem Cells, Aging and Therapy |
| Discussion Leader: Keiko Kashiwagi (Chiba Institute of Science) |
| 7:40 pm - 8:05 pm | Leah Vardy (Institute of Medical Biology)
"A role for polyamine regulators in embryonic stem cell self-renewal and differentiation" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Mitsuharu Matsumoto (Kyodo Milk Industry Co. Ltd.)
"Promotion of longevity due to upreguration of gut bacterial polyamine production"
|
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Robert Casero (Johns Hopkins University)
"Amine oxidases: Potential targets for prevention and therapy" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Translational Control |
| Discussion Leader: Anthony Pegg (Pennsylvania State University College of Medicine) |
| 9:00 am - 9:10 am | Announcements |
| 9:10 am - 9:40 am | R. Jürgen Dohmen (University of Cologne)
"Polyamine-mediated regulation of ornithine decarboxylase antizyme" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Myung-Hee Park (NIH)
"Role of polyamines and eIF5A in eukaryotic translation" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Group Photo / Coffee Break |
| 11:00 am - 11:30 am | Salim Merali (Temple University School of Medicine)
"Modulation of SSAT Translation" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Jian-Ying Wang (University of Maryland School of Medicine)
"Translational regulation through RNA-binding proteins and microRNAs by polyamines controls gut epithelial homeostasis" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Roles of Polyamines in Metabolism and Disease |
| Discussion Leader: Enzo Agostinelli (University of Rome) |
| 7:30 pm - 7:55 pm | Raghu Mirmira (Indiana University School of Medicine)
"Polyamines and hypusine in diabetes pathogenesis and treatment" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:15 pm | Short Talk: Shirly Brenner (Weizmann Institute of Science)
"Inhibition of adipogenesis by polyamine depletion, a mechanistic insight" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Keith T. Wilson (Vanderbilt University)
"Epidermal growth factor activation and polyamines in Helicobacter pylori-induced DNA damage and gastric carcinogenesis" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Kazuei Igarashi (Chiba University)
"Toxicity of acrolein produced from polyamines during brain infarction" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Polyamine Transport and Ion Channel Functions |
| Discussion Leader: Heather Wallace (University of Aberdeen) |
| 9:00 am - 9:10 am | Announcements |
| 9:10 am - 9:40 am | Miki Fujita (RIKEN)
"Transport of paraquat in plants is mediated by a polyamine transporter" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Jacqui Gulbis (WEHI)
"Polyamine binding in the conduction pathway of Kir channels and what it reveals: A changing perspective on pore gating" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Pierre Paoletti (INSERM)
"Molecular action of extracellular polyamines on NMDA receptors" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Therapeutic Development and Applications |
| Discussion Leader: Alex Khomutov (Russian Academy of Sciences) |
| 7:30 pm - 8:00 pm | Patrick Woster (University of South Carolina)
"Epigenetic modulation with synthetic polyamine analogues as a therapeutic strategy" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Margaret Phillips (UT Southwestern)
"Regulatory control of polyamine biosynthesis in Trypanosoma brucei" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Alex Khomutov (Russian Academy of Sciences)
"Methylated and charge-deficient polyamine analogues"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Polyamines in Cancer Development and Therapy |
| Discussion Leader: David Feith (Penn State College of Medicine) |
| 9:00 am - 9:10 am | Announcements |
| 9:10 am - 9:40 am | Susan K. Gilmour (Lankenau Institute)
"Polyamines promote tumorigenesis by generating an immunosuppressive microenvironment" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Jonas Nilsson (University of Gothenburg)
"Role of polyamines in Myc-induced lymphoma" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Lisa Shantz (Penn State College of Medicine)
"Keratinocyte differentiation and expansion in mice with altered polyamines" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Frank L. Meyskens (UC Irvine)
"Followup studies of DFMO plus sulindac for colorectal cancer prevention and the use of DFMO for non-melanoma skin cancer and prostate cancer prevention" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Roles of Polyamines in Bacterial Physiology and Pathogenesis |
| Discussion Leader: Anthony J. Michael (University of Texas Southwestern) |
| 7:30 pm - 8:00 pm | Ilana Kolodkin-Gal (Weizmann Institute)
"Polyamines play key role in the breakdown of bacterial biofilms" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Shin Kurihara (Emory University School of Medicine)
"Putrescine importer PlaP contributes to swarming motility and urothelial cell invasion in Proteus mirabilis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Anthony J. Michael (University of Texas Southwestern)
"The diversity of bacterial polyamine biosynthesis and function" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer Therapeutic Trials Targeting the Polyamine Pathway |
| Discussion Leader: John L. Cleveland (Scripps Florida) |
| 9:00 am - 9:10 am | Announcements |
| 9:10 am - 9:50 am | Michael D. Hogarty (University of Pennsylvania)
"Polyamine antagonist therapeutics for the pediatric cancer neuroblastoma" |
| 9:50 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 11:15 am | André Bachman (University of Hawaii)
"DFMO in pediatric neuroblastoma: Latest progress on Phase I and Phase II clinical trials" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 12:10 pm | Eric A. Lightcap (Millennium Pharmaceuticals)
"Dysregulation of polyamines is the mechanism of cell death by proteasome inhibition" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: How do polyamines do it? |
| Discussion Leader: Chaim Kahana (Weizmann Institute) |
| 7:30 pm - 8:15 pm | TBA (Presentations from GRS or Poster Sessions) |
| 8:15 pm - 8:20 pm | Introduction |
| 8:20 pm - 9:00 pm | Keynote Speaker: Eugene Gerner (Arizona Cancer Center)
"How do polyamines do it?" |
| 9:00 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |