Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Recent Molecular Discoveries
Discussion Leader: Robert Casero (Johns Hopkins University School of Medicine, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Jian-Ying Wang (University of Maryland School of Medicine, USA)
"Polyamines and Non-Coding RNAs in Gastrointestinal Epithelial Homeostasis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Raghu Mirmira (Indiana University, USA)
"Hypusination in Macrophage Function, Diabetes and Metabolic Inflammatory Disease"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
R. Grace Zhai (Miller School of Medicine, University of Miami, USA)
"In Vivo Consequences of Polyamine Imbalance: Insights from a Drosophila Model of Snyder-Robinson Syndrome"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Cancer Prevention and Treatment
Discussion Leader: Michael Hogarty (University of Pennsylvania, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Andrea Flynn (Children's Hospital of Philadelphia, USA)
"Neuroblastoma Trials and DFMO"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Frank Sinicrope (Mayo Clinic, USA)
"Colorectal Cancer Biomarkers and Prevention with DFMO"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:25 am
Richard Klemke (University of California, San Diego, USA)
"Targeting Polyamines in Pancreatic Cancer"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Carolina Sierra (Vanderbilt University Medical Center, USA)
"Gastric Cancer Prevention: Polyamines as Targets and Novel Effects of DFMO"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Aryn Rowsam (Roswell Park Comprehensive Cancer Center, USA)
"Leveraging Polyamine Metabolic Stress to Enhance Sensitivity to Epigenetic Therapy for Prostate Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Heather Wallace (University of Aberdeen, United Kingdom), Susan Gilmour (Lankenau Institute for Medical Research, USA) and Sigrid Roberts (Pacific University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Advances in Inflammation and Cancer Biology
Discussion Leader: Takami Oka (Wakunaga Pharmaceutical Co., Ltd., Japan)
7:30 pm - 8:00 pm
Amaia Zabala-Letona (CIC bioGUNE, Spain)
"Oncogenic Signals Upstream and Downstream of Polyamine Biosynthesis in Prostate Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Susan Gilmour (Lankenau Institute for Medical Research, USA)
"Tumor Immunology and Polyamines"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Otto Phanstiel (University of Central Florida, USA)
"New Drug Strategies Targeting Polyamines in Cancer Biology"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Arginine Metabolism: Upstream Factors in Disease Models
Discussion Leader: Dan Zilberstein (Technion - Israel Institute of Technology, Israel)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Lucile Maria Floeter-Winter (Institute of Biosciences, University of São Paulo, Brazil)
"Arginine Metabolism in Leishmania, Gene Expression Regulation and the Fate of the Infection"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Celeste Simon (Perelman School of Medicine, University of Pennsylvania, USA)
"Arginase 2 Suppresses Renal Carcinoma via Increased Polyamine Toxicity"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Joseph Qualls (Cincinnati Children's Hospital Medical Center, USA)
"Arginine Utilization by Macrophages in the Control of Intracellular Pathogens"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Lori Coburn (Vanderbilt University School of Medicine, USA)
"Arginine and Its Metabolism in Inflammatory Bowel Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations / Late-Breaking Topics
Discussion Leader: Heather Wallace (University of Aberdeen, United Kingdom)
7:30 pm - 7:40 pm
Jenaro Garcia-Huidobro Prieto (Universidad de Talca, Chile)
"Genetic Variability in ODC1 Intron 1 Hosted SNORA80B, a Small Nucleolar (sno)RNA, and Its Potential Consequences on rRNA Processing"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Renee Geck (Harvard University, USA)
"Polyamine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Alexandra McCubbrey (National Jewish Health, USA)
"Polyamine Synthesis in Response to Efferocytosis Regulates Anti-Inflammatory Reprogramming of Macrophages"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Mitsuharu Matsumoto (Research Laboratories, Kyodo Milk Industry Co. Ltd, Japan)
"Functions of Polyamines Produced by the Intestinal Microbiome in Healthy Mice and Humans"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Arif Yurdagul (Columbia University, USA)
"Metabolism of Apoptotic Cell-Derived Arginine and Ornithine into Putrescine by Macrophages Promotes Continual Efferocytosis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Mikhail Nikiforov (Wake Forest School of Medicine, USA)
"Role of Polyamines in Anticancer Drug Resistance"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamines in Aging and Other Diseases
Discussion Leader: Enzo Agostinelli (Sapienza University of Rome, Italy)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Stephan Sigrist (Free University of Berlin, Germany)
"Polyamines, Synaptic Plasticity, Autophagy and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Tobias Eisenberg (University of Graz, Austria)
"Dietary Spermidine Against Age-Associated Decline"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Dwi Kemaladewi (University of Pittsburgh / Children's Hospital of Pittsburgh, USA)
"Polyamines as Protective Disease Modifiers in Congenital Muscular Dystrophy"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Manuela Cervelli (Roma Tre University, Italy)
"SMOX Overexpression: Differential Effects in Skeletal Muscle and Nervous System"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yvonne Latour (Vanderbilt University, USA)
"The Macrophage Reverse Transsulfuration Pathway Mediates Helicobacter pylori Immunopathogenesis by Regulating Polyamine Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Control of Polyamine Levels and Signaling
Discussion Leader: Lisa Shantz (Penn State College of Medicine, USA)
7:30 pm - 8:00 pm
Pavel Baranov (University College Cork, Ireland)
"STREAP (STop-REad-Pause) Mechanism in the Translation of mRNA Encoding a Key Polyamine Pathway Enzyme AdoMetDC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Thomas Dever (National Institutes of Health, USA)
"EIF5A Is a Sensor and Effector for Polyamine Regulation of Antizyme, Antizyme Inhibitor, AdoMetDC and Polyamine Transporter Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Kazuei Igarashi (Amine Pharma Research Institute , Japan)
"Physiological Functions of Polyamines and Their Metabolite, Acrolein"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Roles of Polyamines: Biofilms, Microbiome, Plants and Viruses
Discussion Leader: Autar Mattoo (U.S. Department of Agriculture, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Ece Karatan (Appalachian State University, USA)
"Effects of Polyamines on Vibrio cholerae Biofilms"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Shin Kurihara (Ishikawa Prefectural University, Japan)
"The Genetic Analyses of Polyamine Transport and Biosynthesis in the Dominant Human Gut Microbes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
John Connor (National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, USA)
"Ebolavirus Is Addicted to Polyamines and Hypusinated eIF5A"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Subhash Minocha (University of New Hampshire, USA)
"S-Adenosylmethionine Decarboxylase in Arabidopsis "
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Caleb Bupp (Spectrum Health, USA)
"ODC1: A Rare Patient, a Chance Meeting, a New Genetic Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Polyamines and Cancer Biology
Session in memory of Seymour Cohen.
Discussion Leaders: Myung Park (National Institute of Dental and Craniofacial Research, NIH, USA) and Patrick Woster (Medical University of South Carolina, USA)
5:30 pm - 5:40 pm
Teresa Mastracci (Indiana Biosciences Research Institute, USA)
"Investigating the Biology of DHPS Deficiency, a New Monogenic Disease"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Shannon Nowotarski (Penn State Berks, USA)
"Regulation of Ornithine Decarboxylase (ODC) Induction by UVB Is Dependent on mTORC1 in Human Keratinocytes"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Daniel Lee (University of South Florida, USA)
"Understanding the Polyamine Stress Response in Tauopathies"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:20 pm
Introduction by Discussion Leader
6:20 pm - 7:00 pm
John Cleveland (Moffitt Cancer Center, USA)
"Polyamines in Cancer Biology: Past, Present and Future"
7:00 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
