Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Late-Breaking Discoveries in Polyamine Research
Discussion Leader: John Cleveland (Moffitt Cancer Center, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Daniel Puleston (Icahn School of Medicine at Mount Sinai, United States)
"Instruction of Immune Cell Identity by Polyamines"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Pushpa Pandiyan (Case Western Reserve University, United States)
"Polyamines in Immune Dysfunction During Infections"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Nada Kalaany (Boston Children's Hospital / Harvard Medical School, United States)
"De Novo Ornithine Synthesis is a Dependency in Pancreatic Cancer"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational Regulation by Polyamines
Discussion Leader: Thomas Dever (National Institutes of Health, United States)
9:00 am - 9:30 am
Katja Simon (University of Oxford, United Kingdom)
"Rejuvenating the Immune Response via Translational Regulation of Autophagy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Teresa Mastracci (Indiana University-Purdue University Indianapolis, United States)
"Hypusine Biosynthesis: Lessons Learned from Development and Disease"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
Sebastian Hofer (University of Graz, Austria)
"Spermidine-Mediated Hypusination During Nutrient Deprivation: From Yeast to Humans"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Duojia Pan (UT Southwestern Medical Center and HHMI, United States)
"YAP/TAZ Drives Cell Proliferation and Tumor Growth via a Polyamine-eIF5A Hypusination-LSD1 Axis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Rosa Bordone (La Sapienza, University of Rome, Italy)
"Polyamines and eIF5A in Colorectal Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Leah Vardy (A*STAR Skin Research Labs, Singapore), Manuela Cervelli (Roma Tre University, Italy) and Deborah Altomare (University of Central Florida, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines and Metabolism
Discussion Leader: Dominic Smiraglia (Roswell Park Comprehensive Cancer Center, United States)
7:30 pm - 8:00 pm
Tracy Murray Stewart (Johns Hopkins University, United States)
"Therapeutic Strategies Targeting Polyamine Metabolism in the Tumor Microenvironment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Frederic Bost (INSERM, France)
"Hypusination and Cancer Cell Metabolism"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Leah Vardy (A*STAR Skin Research Labs, Singapore)
"Polyamine Catabolism in Epidermal Wound Healing"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inborn Metabolic Diseases and Polyamines in Medical Genetics
Discussion Leader: Charles Schwartz (Michigan State University, United States)
9:00 am - 9:30 am
Caleb Bupp (Corewell Health/Helen DeVos Children's Hospital, United States)
"Bachmann-Bupp Syndrome: The First Treatable Polyamine Disorder"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Alban Ziegler (Columbia University, United States)
"Hypusination Related Disorders: Genotypic and Phenotypic Spectrum"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Siddharth Banka (University of Manchester, United Kingdom)
"Germline Heterozygous EIF5A Variants Cause a Human Developmental Disorder"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Angela Peron (Università degli Studi di Firenze, Italy)
"Cardinal Signs of Snyder-Robinson Syndrome, a Congenital Polyamine Disorder"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Oluwaseun Akinyele (University of Pittsburgh, United States)
"Characterizing the Phenotypic Abnormalities of a Novel Mouse Model of Snyder-Robinson Syndrome: For Therapeutic Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines and Oxidative Stress in Degenerative Diseases
Discussion Leader: Manuela Cervelli (Roma Tre University, Italy)
7:30 pm - 8:00 pm
Peter Vangheluwe (KU Leuven , Belgium)
"Endo/Lysosomal Polyamine Transporters in Disease"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Kenneth Lee (Penn State University, United States)
"Molecular Mechanism of Polyamine Transport by ATP13A2"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Laura Ciapponi (Sapienza University of Rome , Italy)
"Polyamines in Muscle Function in Drosophila Melanogaster "
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Clinical Prevention and Treatment of Cancer and Other Diseases
Discussion Leader: Deborah Altomare (University of Central Florida, United States)
9:00 am - 9:30 am
Linda DiMeglio (Indiana University, United States)
"Moving to the Bedside: DFMO for Persons with New-Onset Diabetes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Noymi Yam (Orbus Therapeutics, United States)
"Ongoing Clinical Evaluation of DFMO in Malignant Glioma and its Potential to Reduce Hypermutation Induced by Temozolomide Chemotherapy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Elizabeth Bruckheimer (Panbela Therapeutics, United States)
"Clinical Development of Polyamine Targeted Therapies"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Laura Sena (Johns Hopkins University, United States)
"Polyamine Synthesis Drives Prostate Cancer Resistance to Bipolar Androgen Therapy"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Jenaro Garcia-Huidobro Prieto (Universidad de Talca, Chile)
"Genetic Variability in Ornithine Decarboxylase 1 Regulates its Transcription and Polyamine Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Medicinal Chemistry and Pharmacological Targeting of Polyamines
Discussion Leader: Takami Oka (Wakunaga, Japan)
7:30 pm - 8:00 pm
Edmund Ellsworth (Michigan State University , United States)
"Rethinking the Design of Inhibitors of ODC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Mark Burns (Aminex Therapeutics , United States)
"IND to Human Efficacy: Clinical Translation of AMXT 1501 Plus DFMO as Polyamine Transport and Biosynthesis Inhibitors for Cancer Therapy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Otto Phanstiel (University of Central Florida, United States)
"One Compound to Rule Them All: Reprogramming FUSE-controlled Genes in Pancreatic Cancers with FUBP1 Inhibitors"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Polyamines in Plants and Pathogens
Discussion Leader: Subhash Minocha (University of New Hampshire, United States)
9:00 am - 9:30 am
Keith Wilson (Vanderbilt University Medical Center, United States)
"Polyamines and Hypusination in Helicobacter Pylori Immunopathogenesis and Gastric Cancer Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Autar Mattoo (U.S. Department of Agriculture, United States)
"Comparative Genomics-Assisted Mapping of Polyamine (PA) Biosynthetic Pathway in Diverse Plant Systems"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Bryan Mounce (Loyola University Chicago, United States)
"Stuck on You: Polyamines in Virus Attachment and Cellular Entry"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Annette Kaiser (University of Duisburg-Essen, Germany)
"Investigation of an Allosteric Deoxyhypusine Synthase Inhibitor in P. Falciparum"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Arya Vindu (National Institutes of Health, United States)
"Critical Role for Polyamines in Candida albicans Virulence"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
Discussion Leaders: Susan Gilmour (Lankenau Institute for Medical Research, United States) and Enzo Agostinelli (Sapienza University of Rome, Italy)
7:30 pm - 7:40 pm
Chiara D'Ercole (University of Rome 1 "Sapienza", Italy)
"Spatiotemporal Regulation of the Polyamine Pathway in Muscle"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Cristian Fiorucci (Roma Tre University, Italy)
"Spermidine Treatment Affects Gene Expression in Mouse Model of Amyotrophic Lateral Sclerosis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Mollie Shinkle (IUPUI, United States)
"Investigating the Role of Deoxyhypusine Synthase in Neurodevelopment"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
Robert Casero (Johns Hopkins University , United States)
"The Enigma of Polyamine Function in Health and Disease"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure