FRIDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments |
7:40 pm - 8:45 pm | Keynote Address |
| Dr. Robert A. Casero, Jr (Johns Hopkins School of Medicine) "Polyamine metabolism: a target for cancer therapy? prevention? both? or neither?" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm | Social |
SATURDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Polyamine Metabolism, Transport and Regulatory Roles |
| Discussion Leader: Erin Willert |
9:00 am - 9:20 am | Savithri U Nambeesan (Purdue University) "Dissecting roles of polyamines in plant growth and development using forward and reverse genetics" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Colin C Hanfrey (Insitute of Food Research) "Polyamine excess elicits a broad oxidative stress response in plant cells independently of polyamine oxidase" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Yusuke Terui (Chiba Institute of Science) "Synthesis of RpoN, Cra, and H-NS are enhanced by
polyamines at the level of translation in Eschericia coli" |
10:10 am - 10:15 am | Discussion |
10:15 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Takeshi Uemura (Chiba University) "Identification and characterization of polyamine preferential uptake proteins in Saccharomyces cerevisiae" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Xiaojing Wang (Penn State College of Medicine) "Localization of spermine synthase and its possible roles" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Paula L Feinberg-Zadek (Massachusetts Institute of Technology) "Polyamines facilitate a "molecular switch" from LTD to LTP in the medial nucleus tractus solitarius" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Polyamines in Cancer and Metabolic Disease |
| Discussion Leader: Colin Hanfrey |
7:30 pm - 7:50 pm | Shannon L Nowotarski (Penn State College of Medicine) "Egr-1 and ornithine decarboxylase (ODC): A tale of two proteins" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Alison V Fraser (Johns Hopkins School of Medicine) "The effect of Nrf2 Knockdown in human cancer cells" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Andrew Goodwin (Johns Hopkins School of Medicine) "Role of spermine oxidase in inflammation-associated carcinogenesis" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Jennifer J Archer (University of Central Florida) "Inhibition of topoisomerase II by linear anthracene-polyamine conjugates: A new class of DNA intercalators with high polyamine transport selectivity and cytotoxicity" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | Marc Cerrada-Gimenez (University of Kuopio) "Enhanced gluconeogenesis coupled with glucose sensitivity on a transgenic mouse line with activated polyamine catabolism" |
9:30 pm - 9:35 pm | Discussion |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structural and Enzymatic Studies of Polyamine Enzymes |
| Discussion Leader: Marc Cerrada-Gimenez |
9:00 am - 9:20 am | Teraya M Donaldson (Albert Einstein College of Medicine) "Comparative investigation of methylthio activity in Apicomplexan purine nucleoside phosphorylase" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Jeongmi Lee (UT Southwestern Medical Center) "Evolution of β/α-barrel fold decarboxylases" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Kyohei Higashi (Chiba University) "Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli" |
10:10 am - 10:15 am | Discussion |
10:15 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Navneet Kaur (University of Central Florida) "Synthesis, biological evaluation and modeling of the preferred shapes of polyamine transporter ligands and dihydromotuporamine-C mimics: The shovel versus the hoe" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Jolita Seckute (Cornell University) "Structural insights into human spermidine synthase" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Shorena Nadaraia (Penn State College of Medicine) "Structural and functional studies of spermidine synthase" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Closing Remarks: Evaluations and Voting for Talks to be presented at the Gordon Research Conference
|
12:30 pm | Lunch |
6:00 pm | Gordon Research Conference begins with Dinner |