| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Lecture |
| Discussion Leaders: Bianca Verlinden (University of Pretoria) and Jenaro Garcia-Huidobro Prieto (University of Arizona)
|
| 3:45 pm - 4:15 pm | Anthony E. Pegg (Pennsylvania State University)
"50 years of Polyamines"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Polyamines in Cell Metabolism |
| Discussion Leader: Robert Casero (Johns Hopkins University School of Medicine) |
| Student Discussion Leader: Christina Destefano Shields (Johns Hopkins University School of Medicine) |
| 7:30 pm - 7:45 pm | Swati Mandal (National Institutes of Health)
"Depletion of cellular polyamines, spermidine and spermine causes a total arrest in cell proliferation and apoptosis in mammalian cells"
|
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Yukari Maezato (University of Texas Southwestern Medical Center)
"The role of polyamines in the formation and disassembly of bacterial biofilms"
|
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Akihiko Sakamoto (Chiba Institute of Science)
"Polyamine stimulation of eEF1A synthesis based on the unusual position of an SD-like sequence in eEF1A mRNA"
|
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Shirly Brenner (Weizmann Institute of Science)
"Inhibition of adipogenesis by polyamine depletion, a mechanistic insight"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Sho Izawa (Tohoku University)
"Three peroxisome-localized polyamine oxidases in Oryza sativa: kinetic parameters of the recombinant enzymes"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Dong Wook Kim (Tohoku University)
"All polyamine oxidases of Arabidopsis catalyze the back-conversion reaction"
|
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Polyamines in Human Health and Disease |
| Discussion Leader: John L. Cleveland (Scripps Research Institute) |
| Student Discussion Leader: Shannon Nowotarski (Johns Hopkins University School of
Medicine)
|
| 9:00 am - 9:15 am | Enna Dogra Gupta (International Centre for Biotechnology and Genetic Engineering, Delhi)
"Abrogating Oral and Breast Cancer Growth via Targeting Polyamine Pathway through RNAi"
|
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Ryotaro Saiki (Chiba University/ Amine Pharma Research Institute)
"Identification of Proteins Including Acrolein in Saliva of Primary Sjögren Syndrome Patients"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:00 am | Steven Holshouser (Medical University of South Carolina)
"Novel LSD1 inhibitors display selective cytotoxicity in cancer cells and inhibit 3D growth"
|
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Yurika Nishiki (Indiana University School of Medicine)
"p38MAPK-dependent nuclear-cytoplasmic shuttling of DHS and eIF5A regulates nuclear eIF5A hypusination and iNOS translation in islet β cells"
|
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 10:50 am | Pinar Obakan (Istanbul Kültür University)
"Understanding of the roles of polyamines in EBR-induced autophagy"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:45 pm | Polyamines in Parasites |
| Discussion Leader: Otto Phanstiel IV (University of Central Florida) |
| Student Discussion Leader: Yusuke Terui (Chiba Institute of Science) |
| 1:30 pm - 1:45 pm | Dina le Roux (University of Pretoria)
"Structural and functional validation of S-adenosylmethionine decarboxylase as novel drug target in the malaria parasite, Plasmodium falciparum"
|
| 1:45 pm - 1:55 pm | Discussion |
| 1:55 pm - 2:10 pm | Xolani Henry Makhoba (University of Zululand)
"Characterisation of the structure-function status of Plasmodium falciparum AdoMetDC recombinant protein co-expressed in the presence of variable molecular chaperone combinations in E. coli."
|
| 2:10 pm - 2:20 pm | Discussion |
| 2:20 pm - 2:35 pm | Michael Gretes (Oregon Health & Science University)
"Validating Trypanosoma cruzi polyamine biosynthesis as a target for drug design in Chagas disease: an integrated structural biology and molecular genetics approach"
|
| 2:35 pm - 2:45 pm | Discussion |
| 2:45 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
